1. Multi-level atherosclerosis is associated with multi-focal signifi cant stenoses in each of arterial territories.

2. Independent predictors of multi-level atherosclerotic lesions are: mean-CIMT val-ue, claudication, presence of 3 and more risk factors, history of myocardial infarction, creatinine concentration, male gender, low HDL cholesterol level and low body mass in-dex.

3. Ultrasonographic assessment of peripheral arterie stenosis grade is a valuable ex-amination, and its accuracy is 99.7% for detection of stenosis in carotid artery, 96.7%

– in subclavian, 93.2% – in lower limb and 90.3% – in vertebral arteries.

125

4. The increase in IL-6, TNFα, and hs-CRP levels are associated with increasing ex-tent of atherosclerosis, however, three is a difference in distribution of some biomarkers in relation to specifi c territorial involvements.

5. No difference between frequency of allels for IL-6, as well as angiotensin I con-verting enzyme polimorphisms and the number of territories with stenosis ≥ 50% was found.

6. The revascularization procedures are feasible and safe. The frequency of peripro-cedural complications of percutaneous and surgical procedures is strongly related to the number of arteria territories with signifi cant stenosis.

7. The independent risk factors for complication ocurrence are: atherosclerosis extent, claudication, diabetes, creatinine > 105 μmol/L, and the mean-CIMT value ≥ 1.3 mm.

8. A strong association between cardiovascular events frequency and the extent of atherosclerosis is observed, both in patients who underwent revascularization as well as in whose referred to medical treatment only.

9. Following independent predictors of future CV events were identifi ed: atheroscle-rosis extent, mean-CIMT value, cumulation of risk factors, left ventricle ejection frac-tion, claudicafrac-tion, hs-CRP and NT-pro-BNP levels.

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W dokumencie Wielopoziomowa miażdżyca tętnic : czynniki prognostyczne zaawansowania i występowania incydentów sercowo-naczyniowych oraz możliwości terapeutyczne (Stron 122-149)