Znaczenie nadmiernego gromadzenia żelaza i polimorfizmu genu HFE w przewlekłych chorobach wątroby ze szczególnym uwzględnieniem przewlekłego wirusowego zapalenia wątroby typu C
Pełen tekst
(2) 4 1 9 . . 92 96 9216
(3) 9 00
(4) 21 962 !22 6"!6
(5) #680 98$# "
(6) ! 5% $ $
(7) &2$ '
(8) & 4 0(!9 8 0!)196 96 "
(9) ! 5% 0 6
(10) 84 0 2"2! 962 '
(11) & "8 . *+,-./01 . /2-3.450-6789:;,99<=9709: 9,>7-.?@97?A@@0 . 012345BCDB.
(12) 0123457378529. 43
(13) 501234
(14) 23 854 1 21
(15) 74 85 0123
(16) 323 4 1 21
(17) 741 7301234
(18) 2 23 3 525 !" #3 $
(19) 4 0%&'%().
(20) 0120456782.
(21)
(22)
(23) !".
(24) #
(25) $$. %" &" '" &&"()*(+,-.- /*0-.- 1 (23-45.)5* 6.7(15*8- '" &9"(0- 1:,2(;< 1 =,2.<)-45= >()*(+,-.< /*0-.- &?" &@"2.*10*87* .-A-0*45* 1:,2(;< ,<A= &&" &B"#-C)5*24* 32()-C.*45* /*0-.- 5 A(05)(2D5.) 3*4= E 1 A2.*10*87<6> 6>(2(;-6> 1:,2(;< &9" 9" F &G" @" H &%" B" $ # #
(26) $. &I" B&" <+,JA(1-45* .-;=2.*K 3(+A(C-285 /*0-.(1*L 1 A(+,-65 4-C)5*24*3( L*3( 32()-C.*45- = A-6L*4,M1 . A2.*10*87<)5 6>(2(;-)5 1:,2(;< &I" B9" <+,JA(1-45* )=,-6L5 3*4= E 1 A(A=0-6L5 6>(2<6> 4- A2.*10*87* 6>(2(;< 1:,2(;< 99" B@"4-6.*45* ;-C-K >5+,(A-,(0(356.4<6> 5 (;2-.(1-45- )*,(C: 2*.(4-4+= )-34*,<6.4*3( 1 C5-34(+,<6* .*+A(7M1 4-C)5*24*3( 32()-C.*45- /*0-.- 9!" B@&"-C-45* >5+,(A-,(0(356.4* 9!" B@9"-C-45* 9G" BB"6*4- 1A7<1= .-;=2.*K 3(+A(C-285 /*0-.(1*L 5 )=,-6L5 3*4= E 4- A2.*;5*3 A2.*10*87*3( .-A-0*45- 1:,2(;< ,<A= 1 8(4,*8N65* A(+,JA= 6>(2(;< 5 *D*8,<14(N65 0*6.*45- A2.*651152=+(1*3( 9%" B!"*2+A*8,<1- C-0+.<6> ;-C-K @?" !" # @&" G" #
(27) @9" %" O## @@" '" # B!".
(28)
(29) 345679
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``]=OPQ2P3%8GHR L %9B>-<6)'0$!"5#$\^/4)':_<3*69*<6)'0$P-<34)3U$T-.';-<6)3 U$O3*('<6)3=+$%&BF;3'>*)2@U5*>-(*-D2T3.'W3;W3;F*&*4&3-;-D 5*J'&343>-;-E*>(-'F3;J'&3*;&6<3&543>>5-636-DF3DD*>*;&->3W3;6O2V a'6&>-*;&*>-(GHH$GM$H@IN\YG$LK[]=OPQ2P3%8GHR 2 !"5#$T-.';-<6)3U$%&'()*+$\^/4)':_<3*69*<6)'0$O3*('<6)3 =+@\>-;-E*>(-'F';FXY0W*;*.B&'&3-;63;+-(365J'&3*;&6<3&5(3E*> 43>>5-636X*J'&-C3(3'>/+';4>*'&A36\;&GH$H$GMH:GM2N\Y$2LR K !"5#b166-43'&3-;-DXY0W*;*.B&'&3-;6<3&5(3E*>43>>5-636F*J*;F6-; 3;FB4&3-;-D3>-;5-.*-6&'636F36&B>C';4*6X*J'&2-;GHG$G$GI:GLN\Y H$M`IR M !"5$T-.';-<6)3U$O3*('<6)3=+@+'&5-W*;*636';F4(3;34'( 4-;6*cB*;4*6-D3>-;-E*>(-'F3;45>-;345*J'&3&36V@3.J'4&-D5-6&';FE3>'( D'4&->6>*('&*F&-3>-;.*&'C-(36.O3-&*45;-(-W3'GH$`G$2L:K2 N=OPQ2P3%8KR [ !"5#$%&'()*+$O3*('<6)3=+@\6&5*>*';/'66-43'&3-;C*&<**;XVd .B(&3J(34'&3-;';F3>-;3;FB4*F(3E*>3;eB>/3;45>-;345*J'&3&36VZ?X*J'&-( GH$22$GI2:GIKN\Y`$IIL]=OPQ2P3%8IGR 020.
(31)
(32) 345679 9 36
(33) 4 95 3. !"#$"%&'()*+,*-./010234.5.6*(71)859.1*8* :;0"!<=>$"%-.4.?67-6-*@A;.-B@B :;0"!<=>$"'&-.4.?67-6-*@A;.-B@B CD:0EF!"G"!"!<$"@7H@),5.6*1)IJ0J*-67H4)7JB4K L:M0"!<=NE9.1*87@).8J)38*@.86-*@A;.-B@3 :LOP0"G><<=!>"Q48B@@),5*-6J)4B@7J76J7-RJP STP0)@6.-1.0,)@**1;* STU0)@6.-1.0,)@*(.6* STV0)@6.-1.0,)@*V WOT0<X"Y=!>"%)@A01)@7?7I7(@B48B@@),J8-7A60 :Z0[Y#"$\!<YG6B-.71)(.-B@* Z]^0Y$!""<_F<J)-0A]8*?*1.@)*J36-7(B Z]]0Y$!">!>!>G!-*,J36-7(7J7,75R-,7JB `a0b"!>!<!!"Ec!<<,)@*8B-./017J*@.AB/@*+.5 8.J@36-8,75R-,7JB5 Dda0G"!>"F!"E$"c!<,)@*8*()*+,7J**,6BJ7J*@*5)67/.@*5) 8J]0?-8.J1.,+.J)-0A7J.8*?*1.@).J36-7(B6B?0] LdOSC0!>Y>=!""#FE<!<@).*1,7K717J*4K7-7(*A6+0A848.@)7J* J36-7(B Ze0<<<"!>Y$!">F!E/-75*I8.@).9.1*8*JJ36-7(). 67J*-8BA834.8.A?7+7J))@A01)@77?7-@7H4) Z]0Y$!">>>"!"8*J*-67Hf9.1*8*JJ36-7(). ZY$!">EbJ36-7(7JB)@I.,A9.1*8* :g0""!<>4*+,7J)6*8*J*-67Hf9.1*8* D0G!"><!>G!7(-*87J*@).5.67I3-.87@*@A05*/@.6B48@./7 g^0<<"!EF!<$<6-J*+*7I?7J).IhJ)-0A717/)48@* . 020.
(34) 346789. 3434
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
(36) 345657879 48 4
(37) 78 7933
(38) 8 4
(39) 36 3456575
(40)
(41) 7
(42) 5 4 485
(43)
(44) 55 4 3 !"# $ %
(45) 6 3
(46) &43 79 3& 3
(47) 4
(48)
(49) 84 ' % (3 4
(50) 4
(51) 0)*+!)*+,-./01.234567/.819./72-0:+ 6
(52)
(53) 4 7
(54)
(55)
(56) ;'86 5 43
(57) &43
(58) 86 3
(59) &43
(60) 85 8% (3
(61) 354 37;,<=:7 (3
(62) 6 3
(63) &43
(64)
(65) >
(66) '
(67)
(68)
(69) '
(70) %
(71) 7879
(72) 4 %3
(73) &43
(74) ' ?
(75) 4 7
(76) ;' ' (
(77) 4
(78) 8794
(79) '3&@#+
(80) 4 79 %
(81) 4 ' 4 37)*+!)*+ 55
(82)
(83) 6 78
(84) 3
(85) &43% (3 7 75
(86) 4 34878 4 78 84 7
(87) 4 4 488!,A*!7.60BC2..-01 .2D297/.1E: 448 88
(88) 3 ' 4
(89) 7
(90) 879,F$A!G-H652071I27651-/01 7.60B9/.72.: 44
(91)
(92) 4 88J
(93) 4
(94) 8 8% ( 3
(95) 3
(96) 879
(97) 48
(98)
(99) 7
(100) ;6
(101)
(102) 6 3
(103) &47 2!!# K
(104)
(105) 7(&8% (3 4
(106) 4 5786
(107) 4 48 ,
(108) 4 48 : L5 73 4 488 3
(109) 4
(110) 556 ;
(111) &%
(112) '4 7 8'
(113)
(114) 6 4& 4
(115) 7
(116)
(117) ,9
(118)
(119) 4 48 :K 43 79
(120)
(121) 7879887 4
(122) 7 4 4886 8
(123)
(124) '"'
(125) "= )
(126) 4 6 '
(127) 3
(128) &4 3
(129) '
(130) 4 (8 4
(131) 78 '
(132) 3
(133) ;
(134) 4 5 9
(135)
(136) 4 4883
(137) &43
(138) 84 7
(139) 4 4 488M 5' 4 7
(140) 48 4 488NA*!A*K;3
(141) 73
(142) &4 3 8
(143) ?79( 6 4
(144)
(145) 4 5 34 ;A*!A*8 8
(146) 8 (& 9
(147) 78 79@# O 48 (
(148) 65' 6 345657
(149)
(150)
(151) 7 9 78'8 8'4
(152) '3
(153) 84 9
(154) 78 83 &48
(155) 7 (5757; 44
(156)
(157) 4 857 4
(158) 7 ' 4 ' 7 75 73 9
(159)
(160) %
(161) '
(162) 6 3
(163) &43 ,9
(164) 78 34
(165) 4
(166) 78 :P#K4
(167) ;6 6 4
(168) 784 37 5 8 8
(169) 4 34 9 78'88Q '
(170) '
(171) %&4 6
(172) 4
(173) %' 48 4
(174)
(175) 84
(176) '5'
(177) '34
(178) '379 78'88* 7 . 34 9 78'88
(179) '%8 ;';3(
(180) 6
(181) 8 79
(182) 3 &4 6
(183) 879 4 75 7 38 78879783& 4 34878879 % (3
(184) 879
(185) '
(186) 4&> '8 6879% ( 3
(187) 879' 3
(188) &4 35 4
(189) %8 3
(190) 4
(191) 578798 7;4 575 4 3487;9 78'88 9
(192) % (3
(193) 3 &4
(194)
(195) 5
(196) ?
(197)
(198) ""R4
(199) 379
(200) 48797;635
(201) 75 9
(202) 794
(203)
(204) 8(
(205) ' S7 @# T4 39 78'88
(206) 7 4 ;
(207) 6
(208) 7
(209) '
(210) ;6 3
(211) 4 6 3
(212) &4 3$
(213) 6
(214) '%8 ?;
(215) &7 4 4 ';3 79
(216) 3 8
(217) 7 44
(218)
(219) 4 88K4 ;6 6 344 887 4 488 '8 020.
(220) 4567849 57
(221) 8 55 04
(222) 585
(223) 598549 59545
(224) 86 9 . 5845 . !"#$%&'()"*+%&%,()-+.$/0,%1".2"3($-+%42#$-$%. 595
(225)
(226) 96 584 77 8 7
(227) 845 7 9
(228) 847
(229) 8 99
(230) 54 954596: 554 99545 455 4 994 9. 9;459 9 8: 6<: 9889 9 0874 98975
(231) 85
(232) 85 8
(233) 7954545 8:88595
(234)
(235)
(236) 79954
(237) 5 458: 4 45 958 94 45 94
(238) 85 798 =>?@A;BCBDEFBGHIEEJBKLCMBNKJECBOP
(239) 95454 45 94
(240) 85 798 6 5 8494899
(241) 8?7Q2 ?7QR; 8547985 4 96 9S
(242) T8895?7Q2 95
(243) 99
(244) 45 ?7QR 4 945 ; UV95458U 9 9 88 > 98
(245) :8465549
(246) ;56
(247) 9 899
(248) 87 4 4 9:66V6: 94 5 45
(249) 9545849495
(250)
(251) WXY;23Z[?7QR5 949 5
(252) 95454 45 94
(253) 85 798 ?7Q2;597 84 5 UV
(254) 85 8
(255) 5 795454 45 94
(256) 85 798 95
(257)
(258) 5W\X[]55 48: 77 8 5 7899
(259) 8: 9
(260) 68584 8
(261) 98975
(262) 94?7QR8494 UV9545 8:89^ 455 5 5
(263) 94?7Q2 8:88584 48U 945 58
(264) U 9545; 549 65 5 99545;4 45 94
(265) 85 798 ;459 9?7QR 66 995
(266)
(267) : 9
(268) 9997 4 58
(269) U ?7QR 5
(270) 6754V4 54 74 56
(271) 86 5
(272) 9 94 9 5 98 98549 59545; 4 94 4 9985
(273) 4 9WZZ[ ] 54 48
(274) 9 5
(275) 85 798 78 8498849 94 U 45 5 9545 494 849 97 995454 9; 49 865 >?@A]55 995
(276)
(277) : 9
(278) 468
(279)
(280) 9
(281) 5 9545 97
(282) 85 455 4589 5 859465
(283) U 9 98 5 558
(284) 78
(285) 9 7WXY[ P95
(286)
(287) 59544
(288) 594554 5 9 898 947988
(289) _ 98
(290) . 59 9 5 77 87988
(291) 9
(292) 7
(293) 845 9 9
(294) 848:88 99
(295) 549545 84948
(296) 8 57 99545P 45 9954547988
(297) 97948 8594
(298) 9 56788978 9 98 5
(299) 85]5 5 5
(300) 99
(301) 9 6
(302) UV; 485
(303) 5 85 4 945
(304) 8496 5 9 5954=
(305) 9 7 85 98
(306) 894O`
(307) 5
(308) 988 5 8547 5498494 549 97988
(309) ;586 5685 455 5 5 9 8 8:88 587 85
(310) 897 4559 5Q9755878 7988
(311) 99
(312) 4 45 5 64 94 U 9545 85 4 9;594598: 9 8958 455 9 58
(313) U
(314) 8 =?>ab;Acd2b;Acd2e;AcdfO;85
(315) : ;4. 8: 48
(316) 7=Agad2O; 8 : =?X;?Q5; 7 5OP8545 ;9 7857988
(317) 5 99458: 54 9
(318) 85 88 ;58 59
(319) 5 9
(320)
(321) 85 88 98975
(322) 94 4 95 5W2R2;2X3[ 0230.
(323) 3454789
(324) 9
(325) 8. !"#!#$%&&'()*+,'-#,#%&#.*/0+12-3456789:9:;<=<>:?@;AB(* /,/%##%',/%#C2DE) %'C&%#F&G&&(*#%/&BC%.H"I%+GJ,+G+% ,!"BGJ//0+.*/0+,/(*K,'B.G+)"I!%&%&)/#//B')#(!/FG&.*/0+& #!#.*/0//L!/)I!/H/M2NDOPQC"'HC#%+GJQ2R(#G'B(&K4$/!PS42T ,/,'#GB&F&#*#'H"/#!#$%&'2-3C//!'2UVE4C'$B)&,/,C/%#GB #!#$/%B&'()!&&,/C'!*I!&/,/GJ/C%+GJMNDOPW&G0#%/+GJ#!#$XBC%#! (*##(*#%#G#"+)F&G&4C/GJ/C&C/%&GJ*#!G�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`GJ+"!/#%&+C/%/F\.*/0+40KC.G#(!'*!&)#!#$%-3B(*BC%+) %#BGK(*(+GJ(!##XC/#0&H',(G,&%&#.*/0+a`b&c'/,&4*+) /(GM24DD4VU42SN42SdOPQ&'(-#,#%&#.*/0+B(**#!$BC%+)%#B#$%&B(+GJ G+%%&!I++!#//B'#!#,&/*%H/.*/0+P^&(!/,/"/#,#GB%*I ,/CC##%+GJ*#%(,#%*#GB&.*/0+,//C'#!#.*/0//!/)I!/H/B(*#!#$/%# 2-3MN]42SZOP #*/H%#,!"BGJ//0+.*/0++/"#%B#!#$%&)2-3B(*0#C/ "/$/%#P`!"#C#B.(&K%#%&.&/G+%%&!/)GJ#%&)+!/)I!/B&J')/#%B /C,/&C&&))'%//H&G%BH/(,/C##Pe(*/*%./K//B',/G(''(!/C%&/H/ .*/0&,+,&('B(&K*#!$&%C'!GB&(*('/!(+C#G+B%H/+/"#%H/,#!#$%& 2-3MDE4D24V2OP 0220.
(326) 4565789
(327) 856 865 765 77 55 767 65789 7 65 96965677 6 7657 576 78!55! 7"6 6 0#6
(328)
(329) #978$2%3&''()*+,65
(330) 7 " #7 676! 5 57-8"7 57! 6!7 9555 7#57 7785 7
(331) 5" 2((3.2((%+/6 8 7"5 78 7 7 57 65 "#7 78#"57 77 5766 #96 " 765.9" 78
(332) 20.1026655 &025"99 7 357 3476579 7 7 865 7865 7 5 6!7 9576
(333) 7" 6
(334)
(335) 5778 57 34$223513'520%230233*+67" 776!7# 7 575"6575"65
(336) 6787 758 65 785 657 65 7 5 57 7#5 7
(337) 7
(338) !7" 5 65 7+767 #85 7 5 765 8 6 79576 67 785# 757 58 "
(339) 6
(340) "5 " 6#765
(341) 575"
(342) 657 7 7! 7! 6"57 7 77 978 6+ . 9:;:<=>?@ABCDBEFCG@>?HBDABEIBJ>H>EAEKGJA@GCLAH@EFBDMENOPEE QEKCHBQJBRSTUVEUVGCGW>UVEQXYCGWTE. , 865 78#"57 77 5 657#7#7867"5 87 765 7 +37#6#5"5 Z"57"565 7 [!75"7 !579!9665!!
(343) 66 5778 # 6!7 5#96#
(344) 567 5
(345) "9\
(346) 5 768 "5"#9587!+67!"7#
(347) # 6!75 !# 7!&9 687 9 967" 78 !
(348) 89 !
(349) #757 5Z76" 7#! 7 ]^37 [$%&20&*+67!7" 5 !6556"5 6 69#7 65 6$202*+_9"565 58 "
(350) 66 7# "#7 78 8#"57 7 5 !6567! #7 7
(351) #8
(352)
(353) #96 56 7" 8
(354) 7 $(1255*+ `7
(355) 7
(356) ! 65 5
(357) "5 8 #85 77 5 5# 77!5! 865 7! 865 775765 7! 7 565 65 a "#7 788#"57 7"
(358) 6!7" 657 7"
(359) 5 59! 65 67 5+b#" 7!756! "#7 5 766#57!75 !
(360) 6789 7
(361) 5! #6
(362) 58 5
(363) 57 "
(364) 5
(365) " 5 57 #67 559
(366) 78
(367) 7 5# 7!57 7# 665 78#
(368) 5 57 7# 0230.
(369) 4567898
(370) 8 4 4 77 7
(371) 778845
(372) 6
(373) 7
(374) 8 7
(375) 8 4
(376) 74487 7 7778454844948
(377) 4!"#!$% &4
(378) 48 8577 7 7
(379) 4'74
(380)
(381) 445 5 (4
(382) ) 487
(383) 76
(384) *+,82--$48'4 7./0' '798
(385) 4'4 7
(386) 6
(387) 4474 "1%2 7(4*+,5
(388) '4
(389)
(390) 4
(391) (77 333 7 48798)46 (74# 4
(392)
(393) 8 4948
(394) 562#61 637# 4
(395) 8
(396) 8 5(4 48 98 4'77 2//%
(397) 78 48 77 4#
(398) 7 7 7) 644
(399) 64
(400) 47
(401) 77574 4 76
(402) '78 (487
(403) '
(404) 67 *+,8
(405) '74 721"%*+,8 76
(406) '
(407) ( 84
(408) 7478 8 '
(409) 49
(410) 778 7
(411) 47 )
(412) #'4'
(413)
(414) 769):2!-%;5
(415)
(416) 8 744#
(417) 767
(418) 46
(419) 45 7(4*+,'487 445
(420) 7
(421) '
(422) 6
(423) ' #(98
(424) 8 845
(425) #
(426) 7
(427) 87
(428) 474598
(429) 77847
(430) "#3/%<78 67
(431) 7
(432) 7
(433) 76
(434) ' 8
(435) '74 77
(436)
(437) 44*+,7'4'4 487 44
(438) .
(439) 76 9):2 9):1*+,223%=745 7(4*+,
(440) 74 4 8 7 7
(441) 77#7
(442) 6
(443) 4'
(444) 6 5 4
(445) ' (7 77 )
(446) 8 4
(447) 6
(448) 7
(449) 49):2"3% > 8778
(450)
(451) 7 )
(452) 8
(453) 4 79):28 '
(454) 765 7(4*+, 6
(455) 4
(456)
(457) 75 69):13"%?(7
(458) '4(
(459)
(460) *+,9):17 4878
(461) '
(462) 6
(463) ' '4'
(464) 4
(465)
(466) 77 7
(467) 487 7(
(468)
(469) 8 4948 2 15,:&2@1#ABCDEFAGGHGEDIJKLMEGIDALHGECANIOKMEJAJ747'3. 7 5 7(48
(470) 67 8487
(471) 6 4
(472) 7 5PQR&#SKCTLAMIEFCKUECANIVDTCAKMIOKMEJA7 3"#".% 76
(473) 6 8'( 8 7 7
(474)
(475) 47
(476)
(477)
(478) 77'76
(479) 98*+,W
(480) 4474
(481) 7767 7
(482) '4
(483) 767 77 7
(484)
(485) 7 4 X1.1Y5X 1.19 78457
(486) 7Z6
(487) 6 4
(488) 44 4 4
(489) 4 '
(490) 7(
(491) 7 '
(492)
(493).
(494) 65 7(7*+,#
(495) 4 8 76
(496) 4'78 (48.
(497) 76*+,9):221$%?'4'76 77
(498) 6767X1.1Y'46
(499)
(500) 47
(501) 7 6
(502) 8 87 74 42[2142[1/#7457
(503) 8'
(504) 7
(505) 42[1//42[3// ?9Q)47
(506) 7 987676
(507) 4'4 787 7
(508) 487
(509) 7
(510) 6#84 2[3///$3%Z
(511) 7498,4' 488 '487 7487
(512) 47
(513) X1.1Y6
(514) 8 7\
(515) 9 487 7 7(6
(516) 8'
(517) 7
(518) 4/08'4( 48
(519) 6,4'
(520) 421#"0 8]7 3"%P7644 4 X1.1Y8 87 44$/04-$04 '
(521)
(522) 6 '48
(523) 45678
(524) 4474 #
(525) 7498,4' #Q
(526) R9( 4
(527) 6 Q7 1#32%;5
(528) 4876
(529) 6
(530) 6
(531) 4 7 74'4 7
(532) 445 #
(533) 8 445 5 44 47 X1.1Y48 6
(534) 645678 ;
(535) 7
(536) 7 )
(537) 4 '48
(538) 6
(539) '
(540) 6 5 8
(541)
(542) 4 48
(543) 6 #8 5774 4
(544) 9 487
(545) 2
(546)
(547) 8''498 6 488'9(8 '487 74567898
(548) 4474 767
(549) *+,I
(550) 67
(551) 8
(552) 207 7 )
(553) 4 '48
(554) 678
(555)
(556) 2.% 0230.
(557) 45657859
(558) 57
(559) 95697
(560) 68
(561) 5 95756 5!888 "9
(562) #
(563) !57688 5$75 %9578
(564) 9 5& 956
(565) 785'
(566) !55()*0+,*5 9'!89- 9878%85 8%8
(567) !975 $69
(568) 59!9&88 996957
(569) 8. 578
(570) '
(571) !55 2,*69((*.99&9/0)01233)2(24569 $8
(572) 7855
(573) &9 965 8 '
(574) !59
(575)
(576) 6
(577) 69578
(578) 8%
(579) 6!578% 8
(580) 80)*9 2*:2)45; 75 5 <
(581) 799
(582)
(583)
(584) 878
(585)
(586)
(587) 6797578
(588) 9
(589) !9759
(590) 8%75
(591) 7857 877.&
(592) 796<8$.
(593) 8
(594) &.9 9 87788% 5$. 9 $8
(595) 785 5
(596) &9 965 8 '
(597) !59
(598) 88
(599) 7
(600) - 55'
(601) 785 8 58 .
(602) 59 998 9'578
(603) 5!9.9! 7 %9578
(604)
(605) 97
(606) 5 9!87
(607) &9: 23(+=2,045>
(608) 9 9959!9&8875 $69
(609)
(610) '78957
(611) 85!
(612) '7
(613) 965798 987 955!7.88$57.<8 9&
(614) 7
(615) $8>"?@AB?"@CBD@2BD@2,>E?@F2: 200=)332,(49 5 578
(616) <797$.
(617) .578579 657.22(22245 99793*.9 $.75G?.
(618) 9. 959% 5 8%8
(619) 57$5% .
(620)
(621) 9&97$/0)0197$
(622) 785$G=(H8G8 =( :0&68
(623) 58
(624)
(625) 5 $8
(626) 78
(627) .8 675 5 5&87$5I96 '78
(628) 7896957
(629) &9 8575/0)0178
(630) 55796!5575G=(H.5 5
(631) 7.5
(632) 7
(633) 8
(634) 57 9 8
(635)
(636) 7$ 9 9
(637)
(638) 8 7979
(639) G?220=45I95 89788. 565 9!
(640) !5 7.9$995756579'
(641) 55G=(H 5968
(642) !78
(643) 78
(644) 956869 59!9&87
(645) &9& 956
(646) 785'
(647) !555J
(648) 675 578
(649) 5!!
(650) !5G=(H8% $% 98$ 9!58.9 .75G?.
(651) 9. 959%9 75789!5$9&!7$ 5579 759
(652) 75!76857
(653) &99!89 <859<89!9&88 8. 5785'
(654) !555;
(655) 8657
(656) 9 $8
(657) 7858
(658) 57..
(659)
(660) 9&99 5 '78
(661) 75 8!97
(662) &959!9&87
(663) &9 & 956
(664) 785'
(665) !55 5957
(666)
(667) 962690*22,3455555G=(H %
(668) 9!58 5 55 8
(669) % 98$2+*00,*23+45.998.
(670)
(671) 9&97.
(672) 79 88
(673) !89'!8
(674)
(675) $8
(676) 78
(677) 75&967.9 5 8. 5785'
(678) !55&778
(679) 96 9 58$5
(680) 89.
(681) 87.5 5
(682) &9 965 8'
(683) !59
(684) 2=045H 957
(685)
(686) 75
(687) 78
(688) .585969659
(689) &9778559&
(690) 77
(691) &9 9'
(692) 8
(693) -775 8%
(694) 78
(695) 5 995 98$ 9 8 55$ 9 999 9
(696) &9 56 78 78
(697) 78555'
(698) 7858 5855!
(699) 785$ 9 G/KG4K87568
(700) 7
(701) &9 9'85 5!9.9!23=3L33=,)345 >
(702) 8969% 98 57859!89 <8
(703) G?
(704) =+/8
(705) =+/ :5 I %9578
(706) 957
(707) &95!!!
(708) !5=+/ 69 9 78 5 55 8
(709)
(710) 5957
(711)
(712) 685!
(713) 96,=*692=*5 65
(714) 79 5587568
(715) 7
(716) &9& 956
(717) 785 '
(718) !55% 98$9979+*2=L3045&
(719) 957
(720) 8$
(721)
(722) &99!89 <875&967$ 96857$5
(723) &9 965 8'
(724) !59
(725)
(726) &!78
(727) 768
(728) 68
(729) 7858 /0)0122045 0230.
(730) 4556789 8
(731) 87 56
(732) 8
(733) 696765 78 9 5 5 8 !6 8!
(734) 8 8
(735) !5 678 6
(736) 858956"8 "6587#!6 8!
(737) 8 8$%3&' (8 6878"656 67 !
(738) 5 )698
(739)
(740) )5 658! 68 "585! 8969
(741) 5! 8
(742) 8! 5656"8
(743) 87855 !8
(744) 8 7
(745) 6 7 65 6 8 5 68
(746) 95!*
(747)
(748) 8+ 5 68958+
(749) )65 ',8 69665 5 66"88)69!8
(750) ! 5 65857898" 5
(751) 8685 6787
(752)
(753) 885 6 -) 7
(754) 6) ' . 6
(755) 56"
(756) 8 65 6)69 8)6 6/6)!
(757) 6
(758)
(759) 58 55!!8
(760)
(761) 885!95!'08
(762) 885!!8
(763) -6
(764) 858
(765) 586"8
(766) 8
(767) 8!6 86
(768) 8596)96 6
(769) 885 6
(770) 88
(771) 885 5 68
(772) 6!
(773) 8"65"988#1# 8 8
(774) 586$21223&'4+
(775) !8
(776) 5!8
(777) 6
(778) ! 6
(779) !6 86
(780) 8 65 565 68
(781) 8+/6
(782) 8958
(783) 5 6
(784) 67
(785) 696-6!8
(786) 8
(787) 8*7
(788) 696-6
(789) 867965 6
(790) 875 5 698!898!8
(791) 8-65 8
(792) 898!898!8
(793) 8
(794) 878
(795)
(796) 6
(797) 886$22%12&' 58+/785 5 6
(798) 56"8"
(799) 8 65 )697879 !8
(800) !. 66,8 8
(801) 7
(802) 696-7898"
(803) 87
(804) 66
(805) 87855 6 7
(806) 696-6"87965
(807) 8756"87-57
(808) 6 6"!8
(809) 88
(810) 6 "65- 6 6 7
(811) 7
(812) 67
(813) 885!79 5 65!8
(814) 895!
(815) !+/)879 856787
(816) 665856
(817) 87
(818) ! 9 56' . 0230.
(819) 45789
(820)
(821) . !!"#!$%#"&#'%!!(()#* +!'&"#,!"&%#!'-'.#"%#!/'#(%#"!!.# (.#.#'!,#'%')!-"#'%!$#%-+ !###$")-"''!#$#'#"'$##$$#!%#('! ###''!'!'(0 1,!'&"#,!"&%#!-(!.-234%#%-(!# %')##$#!!'!$'-''-'!!.#"%#!/'0 1%'#,!#!.#"!!"#%##.!'(!#'#! #$'#"-.'.##'%#'!-'"%#)!.#.#'! /'0 1%)-'-'.#"%#!/'#(!-(!.-234 %'!. %')#$#%').#'%!$#%-#,! %#"&%-##5 #,!'!%'!!-"#.#'#'#(-#.) "&%"0"#,!$#!$#####.#0 . 0230.
(822) 45789
(823) 8
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
(825) 4565789
(826) 65789788 9
(827) 757579
(828) 796597 8
(829) 578595
(830) 5 89 757556
(831) 8956888 65!89"789 9#96
(832) 79$6 7% 96%&6 5'
(833) 5( 85)5*+% ,5
(834) 9 56
(835) 9789565!
(836) 57
(837) 6 ,89
Powiązane dokumenty
Miller werkt met gemidd elden ,hetg een als een bezwaar kan worden aangemerkt. Misschien is de faktor-methode volgens Guthrie,die per apparaat
Jeżeli cel i znaczenie przekładu polega na przeniesieniu dzieła literackiego jako złożonej struktury językowej w strukturalne warunki innego języka i jeśli tłumacz dla
W rzeczy samej pomylono tu kwestię statusu języka w ogóle, w tym statusu języka specjalistycznego z tym, co określane jest mianem język ekonomii (jako pewnego uogólnienia,
W obrębie zespołu głównyCh wapieni skalistych.. wyróżnić można liczne odmiany wapieni
Skoro już tyle się rozpisałem o Norwidzie, dodam jeszcze, że szy kuję do druku dziesięć nieznanych jego wierszy (przeważnie dro biazgi lub ułamki), a między nimi
Oczywiście tłumaczenie queero- we nie ogranicza się jedynie do tłumaczenia pisemnego, możliwe jest również tłumaczenie queerowe ustne 4?. W tym artykule skupiam się jed- nak
Ainsi, dans les deux œuvres éminentes de la littérature acadienne dont les fragments nous analysons ici, Petites difficultés d’existence de France Daigle et
Autor nie poprzestaje jednak na odwołaniu się do osiągnięć filozofii i ukazuje czytelnikom także podstawy bioetyki z perspektywy teologii.. Od- wołuje się do biblijnej