Mean Platelet Volume, Neutrophil-Lymphocyte Ratio and Platelet-Lymphocyte Ratio in Severe Preeclampsia

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(1)P R A C E. Ginekol Pol. 2014, 85, 197-203. O R Y G I N A L N E po ł o ż n i c t wo. Mean Platelet Volume, Neutrophil-Lymphocyte Ratio and Platelet-Lymphocyte Ratio in Severe Preeclampsia Średnia objętość płytek krwi, wskaźnik neutrofile/limfocyty oraz wskaźnik płytki krwi/limfocyty w ciężkiej preeklampsji $OL<DYX]FDQ10HWHdD÷ODU1<XVXIhVWQ16HUGDU'LOED]1øVPDLOg]GHPLU2 (OLI<ÕOGÕ]16ÕWNÕg]ELOJHo16HODKDWWLQ.XPUX1. 1 2. Department of Obstetrics and Gynecology, Düzce University Faculty of Medicine, Düzce, Turkey Department of Obstetrics and Gynecology, International Medicana Hospital, İstanbul, Turkey. Abstract Objectives: The aim of the study was to compare the changes in the values of leukocytes, neutrophils, lymphocytes, mean platelet volume (MPV), and systemic inflammatory response (SIR) markers (neutrophil-lymphocyte ratio/ platelet-lymphocyte ratio) in patients with severe preeclampsia (PE) of healthy pregnant and non-pregnant women. Material and methods: Hematological parameters including MPV, and SIR markers [neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR)] were compered between the between three groups comprising of women with severe PE, healthy pregnant women and healthy non-pregnant women. Results: MPV and PLR did not show statistically significant differences between the three groups (p=0.081, p=0.098). NLR showed a statistically significant difference between the three groups (p=0.000). NLR values of patients with severe PE were statistically significantly higher than healthy non-pregnant women (p=0.000). No statistically significant difference was found between patients with severe PE and healthy pregnant women (p=0.721). The cut-off value of the leukocyte number for severe PE was 7.6 x 103/ml, with 76.7% sensitivity and 60.6% specificity. The cut-off value of neutrophil number was 6.4 x 103/ml for the group with severe PE, with 76.7% sensitivity and 69% specificity.. Corresponding author: Ali Yavuzcan Department of Obstetrics and Gynecology, Duzce University School of Medicine, 81000, Konuralp, Duzce, Turkey mobile: +90 (532) 634 54 31 e-mail: draliyavuzcan@yahoo.com. Nr 3/2014. © Polskie Towarzystwo Ginekologiczne. Otrzymano: 31.05.2013 Zaakceptowano do druku: 16.10.2013. 197.

(2) P R A C E O R Y G I N A L N E poł ożn i ct wo. Ginekol Pol. 2014, 85, 197-203. Ali Yavuzcan et al. Mean Platelet Volume, Neutrophil-Lymphocyte Ratio and Platelet-Lymphocyte Ratio in Severe Preeclampsia.. Conclusions: Our results showed that MPV level did not differ among patients with severe PE, healthy pregnant women and non-pregnant women. NLR cannot be used to identify patients with severe PE. PLR measured before termination of pregnancy is not an effective marker for severe PE, either.. Key words leukocytes / mean platelet volume / neutrophils / neutrophil-lymphocyte ratio / platelet-lymphocyte ratio / preeclampsia / Streszczenie Celem badania było porównanie zmian w ilości leukocytów, neutrofilów, limfocytów, średniej objętości płytek krwi (MPV) a układową odpowiedzią zapalną (SIR)wyrażoną za pomocą markerów (wskaźnik neutrofile/limfocyty oraz wskaźnik płytki krwi/limfocyty) u pacjentek z ciężką preeklampsją (PE), u zdrowych ciężarnych i u nieciężarnych kobiet. Materiał i metoda: Parametry hematologiczne oraz MPV i markery SIR (wskaźnik neutrofile/limfocyty NRL oraz wskaźnik płytki krwi/limfocyty PLR) zostały porównane między trzema grupami pacjentek: z ciężką preeklampsją, zdrowymi ciężarnymi i zdrowymi nieciężarnymi kobietami. Wyniki: MPV oraz PLR nie wykazały istotnych różnic pomiędzy porównywanymi grupami (p=0,081, p=0,098). NRL różniło się istotnie w badanych grupach (p=0,000). Wartości NRL były istotnie wyższe w grupie z ciężką PE niż u zdrowych nieciężarnych kobiet (p=0,000). Nie znaleziono istotnej różnicy pomiędzy pacjentkami z ciężką PE a zdrowymi ciężarnymi (p=0,721). Punkt odcięcia liczby leukocytów dla ciężkiej PE wynosił 7,6x103/ml, przy 76,7% czułości i 60,6% specyficzności. Punkt odcięcia liczby neutrofili dla ciężkiej PE wynosił 6,4x103/ml, przy 76,7% czułości i 69% specyficzności. Wnioski: Nasze wyniki pokazują, że poziom MPV nie różni się pomiędzy pacjentkami z ciężką preeklampsją, zdrowymi ciężarnymi i zdrowymi nieciężarnymi kobietami. NRL nie może być wykorzystany do identyfikacji pacjentek z ciężką PE. Również pomiar PRL przed zakończeniem ciąży nie jest skutecznym markerem ciężkiej PE.. Słowa kluczowe: leukocyty / ĞreGnia oEMĊtoĞü páytek krZi / neutro¿le / ZskaĨnik neutro¿le-limIocyty / ZskaĨnik páytki krZi-limIocyty / preeklampsja /. List of abbreviations: PE, preeclampsia; MPV, mean platelet volume; SIR, systemic inflammatory response NLR, neutrophil-lymphocyte ratio; PLR, platelet-lymphocyte ratio; g/dL, GramsPerDeciLiter; fL, FemtoLiter; /uL, PerMicroLiter; 103/uL, ThousandPerMicroLiter; Hb, Hemoglobin; ROC, Receiver operating characteristic. Introduction 3UHHFODPSVLD 3(

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(62). P value*. . . . 00. 0. 0. 00. 0.000. . 0. . 0.000. /\PSKq. . 0. 0. 00. Platelet. 0000. . 0. 0.001. MPV. q. q. q. 0. 00. . 00. 1/5q. 00. . 00. 0.000. P/5q. 0. . . 00. q PeaQ VtaQGaUG GeYLatLRQ 1 QXPEeU RI SatLeQtV +E KePRJlRELQ :%& ZKLte ElRRG Fell /\PSK l\PSKRF\te MPV PeaQ Slatelet YRlXPe 1/5 QeXtURSKLll\PSKRF\te UatLR P/5 Slateletl\PSKRF\te UatLR P 00 YalXe ZaV UeJaUGeG aV VtatLVtLFall\ VLJQL¿FaQt. Table III. Bilateral comparison of MPV, NLR and PLR values between the groups. 6eveUe SUeeFlaPSVLa 1

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(114) P R A C E. Ginekol Pol. 2014, 85, 197-203. O R Y G I N A L N E po ł o ż n i c t wo. Ali Yavuzcan et al. Mean Platelet Volume, Neutrophil-Lymphocyte Ratio and Platelet-Lymphocyte Ratio in Severe Preeclampsia.. Authors’ Contribution 1. Ali Yavuzcan – study design, methodology, interpretation of results and writing of the text – corressponding author. 2. Mete Çağlar – study design and methodology. 3. Yusuf Üstün – statistical analysis. 4. Serdar Dilbaz – Study design 5. İsmail Özdemir – Scientific control of the text. 6. Elif Yıldız – data collection. 7. Sıtkı Özbilgeç – data collection. 8. Selahattin Kumru – scientific control of the text. Authors’ statement ³ >RS] K\^SMVO RK] XY^ LOOX Z\O`SY_]Vc Z_LVS]RON KXcaRO\O >RS] K\^SMVO S] XY^. currently under consideration for publication elsewhere. ³ >RO K_^RY\] NOMVK\O XY ºXKXMSKV SXÔ\O]^] ³ +Xc MK]O YP ]MSOX^SºM _X\OVSKLSVS^c SP NOÔMÔN SX ^RS] Ôb^ ^RO :YVS]R. 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