Carotid intima-media thickness in postmenopausal women is associated with an endometrial thickness greater than 5 mm

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(1)P R A C E O R Y G I N A L N E poł ożn i ct wo. DOI: 10.17772/gp/61329. Ginekol Pol. 2016, 87, 116-123. Carotid intima-media thickness in postmenopausal women is associated with an endometrial thickness greater than 5 mm Grubość błony środkowej i wewnętrznej tętnicy szyjnej u kobiet po menopauzie jest związana z grubością endometrium większą niż 5mm .

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(3) !"#$$% ¹ Merkezefendi State Hospital, Department of Obstetrics and Gynecology, 45000 Manisa, Turkey ² Merkezefendi State Hospital, Department of Radiology, 45000 Manisa, Turkey ³ Ege University, Institute of Health Sciences, Department of Stem Cell, 35100 Izmir, Turkey 4 Merkezefendi State Hospital, Department of Biochemistry, 45000 Manisa, Turkey 5 Celal Bayar University, School of Medicine, Department of Public Health, 45050 Manisa, Turkey. Abstract Aim: The aim of this study was to investigate the relationship between ultrasonographic carotid intima-media thickness (C-IMT) and visceral fat thickness (VFT) and an endometrial thickness (ET) of more than 5 mm in postmenopausal women. Methods: C-IMT, VFT, and ET measurements were performed in 63 postmenopausal women using ultrasonography. The relationships between ultrasonographic data and demographic data, anthropometric measurements, such as waist circumference, metabolic syndrome parameters, and insulin resistance were examined. Moreover, the role of VFT and C-IMT in predicting an ET of more than 5 mm was investigated. Results: Only the C-IMT was higher in the ultrasonographic measurements of women with an ET >5 mm (p = 0.03). Insulin resistance was also significantly higher in these women (p = 0.03). ET showed a positive correlation with VFT and body mass index (BMI) (r = 0.286, p = 0.02 and r = 0.249, p = 0.04), and C-IMT showed a positive correlation with age, pregnancy, parity, and time since menopause (p<0.05). Multivariate analysis showed that highC-IMT levels were associated with an ET >5 mm (p = 0.04). Conclusions: There was a positive correlation between the ultrasonographic measures of VFT and ET, and highC-IMT levels were independently associated with an ET>5 mm. Thus, C-IMT may be a predictor of pathologic ET in the postmenopausal period.. Key words: menopause / carotid intima-media thickness / body fat distribution / / endometrial thickness /. Corresponding Author: Fatma Eskicioğlu 5774 street No:12/B/9 Güzelyurt/Yunus Emre, Manisa, Turkey 45030 Tel: +90(505)2595349 Fax:+90(236)2327462 e-mail: fatmaeskicioglu@gmail.com. 116. © Polskie Towarzystwo Ginekologiczne. Otrzymano: 08.10.2015 Zaakceptowano do druku: 11.11.2015. Nr 2/2016.

(4) Ginekol Pol. 2016, 87, 116-123. DOI: 10.17772/gp/61329. P R A C E. O R Y G I N A L N E po ł o ż n i c t wo. Fatma Eskicioğlu et al. Carotid intima-media thickness in postmenopausal women is associated with an endometrial thickness greater than 5 mm.. Streszczenie Cel pracy: Celem pracy była zbadanie związku między grubością błony środkowej i wewnętrznej tętnicy szyjnej (C-IMT) a grubością tkanki tłuszczowej trzewnej (VFT) oraz grubością endometrium (ET) większą niż 5 mm u kobiet po menopauzie. Metody: Pomiary C-IMT, VFT, i ET wykonano u 63 kobiet po menopauzie przy pomocy ultrasonografii. Zbadano związek między wynikami ultrasonograficznymi a danymi demograficznymi, pomiarami antropometrycznymi, takimi jak obwód w talii, parametry zespołu metabolicznego i oporności na insulinę. Co więcej, oceniono role VFT i C-IMT w przewidywaniu ET większego niż 5 mm. Wyniki: Tylko C-IMT było wyższe w pomiarach ultrasonograficznych u kobiet z ET >5 mm (p = 0.03). Insulinooporność była również istotnie wyższa u tych kobiet (p = 0.03). ET wykazało pozytywną korelację z VFT i BMI (r = 0.286, p = 0.02 i r = 0.249, p = 0.04), a C-IMT wykazało pozytywną korelację z wiekiem, ciążą, rodnością i czasem od menopauzy (p<0.05). Analiza wieloczynnikowa pokazała że wyższe poziomy C-IMT wiązały się z ET >5 mm (p = 0.04). Wnioski: Wykazano pozytywną korelację między ultrasonograficznymi pomiarami VFT i ET, a wysokie poziomy C-IMT niezależnie wiązały się z ET>5 mm. Dlatego C-IMT może być predyktorem patologicznego ET u kobiet pomenopauzie.. Słowa kluczowe: menopauza /

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