• Nie Znaleziono Wyników

Indukcja mikrojąder we krwi obwodowej i szpiku kostnym samców myszy narażanych subchronicznie na działanie promieniowania X i bisfenolu A

N/A
N/A
Protected

Academic year: 2021

Share "Indukcja mikrojąder we krwi obwodowej i szpiku kostnym samców myszy narażanych subchronicznie na działanie promieniowania X i bisfenolu A"

Copied!
7
0
0

Pełen tekst

(1)

5RF]3DQVWZ=DNO+LJ1U $GUHVGRNRUHVSRQGHQFML-RDQQD5DG]LNRZVND=DNáDG2FKURQ\5DGLRORJLF]QHML5DGLRELRORJLL 1DURGRZ\,QVW\WXW=GURZLD3XEOLF]QHJR±3DĔVWZRZ\=DNáDG+LJLHQ\:DUV]DZDXO&KRFLPVND WHOID[HPDLOMUDG]LNRZVND#S]KJRYSO ‹&RS\ULJKW1DURGRZ\,QVW\WXW=GURZLD3XEOLF]QHJR3DĔVWZRZ\=DNáDG+LJLHQ\

,1'8.&-$0,.52-Ą'(5:.5:,2%:2'2:(-,6=3,.8.2671<0

6$0&Ï:0<6=<1$5$ĩ$1<&+68%&+521,&=1,(1$'=,$à$1,(

3520,(1,2:$1,$;,%,6)(12/8$

,1'8&7,212)0,&5218&/(,,13(5,3+(5$/%/22'$1'%21(

0$552:5(7,&8/2&<7(62)0$/(0,&($)7(568%&+521,&

(;32685(72;5$<6$1'%,63+(12/$

-RDQQD5DG]LNRZVND$QHWD*DMRZLN0DáJRU]DWD'REU]\ĔVND =DNáDG2FKURQ\5DGLRORJLF]QHML5DGLRELRORJLL 1DURGRZ\,QVW\WXW=GURZLD3XEOLF]QHJR±3DĔVWZRZ\=DNáDG+LJLHQ\:DUV]DZD 6áRZDNOXF]RZHELVIHQRO$SURPLHQLRZDQLH;VNRMDU]RQHG]LDáDQLHPLNURMąGUD .H\ZRUGV ELVSKHQRO$;UD\FRPELQHGH[SRVXUHPLFURQXFOHL 675(6=&=(1,( :SURZDG]HQLH3URPLHQLRZDQLHMRQL]XMąFHLNVHQRHVWURJHQ\Z\VWĊSXMąSRZV]HFKQLHZĞURGRZLVNXF]áRZLHND%LVIHQRO $ %3$ XĪ\ZDQ\MHVWSRGF]DVSURGXNFMLSROLZĊJODQyZRUD]Ī\ZLFHSRNV\GRZ\FKVWDQRZLąF\FKVNáDGQLNPLQVRF]HZHN GRRNXODUyZZ\SHáQLHĔGHQW\VW\F]Q\FKSá\W&'V]\ERNLHQQ\FKSRNU\ZLQVWUXPHQWyZRSDNRZDĔRUD]SRMHPQLNyZQD QDSRMHDOHWDNĪHZ\UREyZGODG]LHFLEXWHOHNWDOHU]\NyZNXEHF]NyZRUD]HOHPHQWyZVPRF]NyZĩ\ZLFHHSRNV\GRZH ZFKRG]ąWHĪZVNáDGSRZáRNZHZQĊWU]Q\FKSRMHPQLNyZGRSU]HFKRZ\ZDQLDĪ\ZQRĞFL3URPLHQLRZDQLHMRQL]XMąFHZ\-NRU]\VW\ZDQHMHVWPLQZGLDJQRVW\FHUHQWJHQRZVNLHMWHUDSLLFKRUyEQRZRWZRURZ\FKZSU]HP\ĞOHQDXFH &HOEDGDĔ &HOHPEDGDĔE\áRRNUHĞOHQLHZSá\ZXELVIHQROX$SURPLHQLRZDQLD;RUD]VNRMDU]RQHJRG]LDáDQLDREXF]\QQL-NyZQDLQGXNFMĊPLNURMąGHUZUHWLNXORF\WDFKNUZLREZRGRZHMLV]SLNXNRVWQHJRP\V]\ODERUDWRU\MQ\FK 0DWHULDáLPHWRGD 'RĞZLDGF]HQLHSURZDG]RQRQDVDPFDFKP\V]\3]K6ILVSU]H]W\JRGQL=ZLHU]ĊWRPSRGDZDQRELVIH-QRO$ZZRG]LHGRSLFLD PJNJPFPJNJPFPJNJPF QDSURPLHQLDQRGDZNą*\SURPLHQLRZDQLD;DOER SRGGDZDQRVNRMDU]RQHPXG]LDáDQLXREXW\FKF]\QQLNyZ *\PJNJPF%3$ .UHZ]Ī\á\RJRQRZHMSRELHUDQR SRXSá\ZLHLW\JRGQLRGUR]SRF]ĊFLDHNVSR]\FMLDV]SLNNRVWQ\W\ONRSR]DNRĔF]HQLXQDUDĪDQLD2FHQLDQRF]ĊVWRĞü Z\VWĊSRZDQLDPLNURMąGHUZUHWLNXORF\WDFK :\QLNL=DUyZQRELVIHQRO$MDNLSURPLHQLRZDQLHMRQL]XMąFHVW\PXORZDá\LQGXNFMĊPLNURMąGHUZUHWLNXORF\WDFKNUZL REZRGRZHMLV]SLNXNRVWQHJR:QDVWĊSVWZLHQDSURPLHQLDQLD]ZLHU]ąWSURPLHQLRZDQLHP;LQGXNFMDPLNURMąGHUZ]UDVWDáD SRGF]DVJG\ZUH]XOWDFLHSRGDZDQLDELVIHQROX$PDODáDSURSRUFMRQDOQLHGRF]DVXWUZDQLDHNVSR]\FML6NRMDU]RQHG]LDáDQLH SURPLHQLRZDQLDMRQL]XMąFHJRL%3$LQGXNRZDáRZ\VWĊSRZDQLHPLNURMąGHU]H]QDF]QLHZ\ĪV]ąF]ĊVWRĞFLąZSRUyZQDQLX GRHIHNWyZG]LDáDQLDVDPHJR%3$&]ĊVWRĞüZ\VWĊSRZDQLDPLNURMąGHUZNUZLREZRGRZHM]ZLĊNV]DáDVLĊZPLDUĊXSá\ZX F]DVXRGUR]SRF]ĊFLDGRĞZLDGF]HQLD:V]SLNXNRVWQ\PZHZV]\VWNLFKJUXSDFKREVHUZRZDQR]QDF]QLHQLĪV]ąOLF]HEQRĞü UHWLNXORF\WyZ]PLNURMąGUDPLQLĪZNUZLREZRGRZHM :QLRVNL 6XEFKURQLF]QHQDUDĪHQLHQDELVIHQRO$SURZDG]LGR]PQLHMV]HQLDZUDĪOLZRĞFLPDWHULDáXJHQHW\F]QHJRUHWLNX-ORF\WyZQDLQGXNFMĊXV]NRG]HĔ3URPLHQLRZDQLH;MHVWSUDZGRSRGREQLHF]\QQLNLHPGHF\GXMąF\PRXV]NRG]HQLX'1$ ZQDVWĊSVWZLHVNRMDU]RQHJRG]LDáDQLD $%675$&7 %DFNJURXQG ,RQL]LQJUDGLDWLRQDQG[HQRHVWURJHQVDUHZLGHO\SUHVHQWLQWKHKXPDQHQYLURQPHQW%LVSKHQRO$ %3$ LVXVHG WRPDQXIDFWXUHSRO\FDUERQDWHSODVWLFVHSR[\DQGSRO\HVWHUUHVLQV%3$LVSUHVHQWLQDJUHDWYDULHW\RISURGXFWVLQFOXGLQJ EDE\ERWWOHVFRPSDFWGLVNVWKHUPDOSDSHUVDIHW\KHOPHWVEXOOHWUHVLVWDQWODPLQDWHSODVWLFZLQGRZVFDUSDUWVDGKHVLYHV protective coatings, powder paints, polycarbonate bottles and containers, the sheathing of electrical and electronic parts, GHQWDOILOOLQJV)RRGDQGEHYHUDJHFDQVDUHSURWHFWHGIURPUXVWLQJDQGFRUURVLRQE\WKHDSSOLFDWLRQRIHSR[\UHVLQVDVLQQHU

(2)

-5DG]LNRZVND$*DMRZLN0'REU]\ĔVND

18 Nr 1

FRDWLQJV+XPDQDFWLYLWLHVLQYROYLQJWKHXVHRIUDGLDWLRQDQGUDGLRDFWLYHPDWHULDOVLQLQGXVWU\DJULFXOWXUHDQGUHVHDUFKFDXVH UDGLDWLRQH[SRVXUHLQDGGLWLRQWRQDWXUDOH[SRVXUHFRPLQJIURPFRVPLFUD\VDQGQDWXUDOO\RFFXUULQJUDGLRDFWLYHVXEVWDQFHV

2EMHFWLYH7KHDLPRIWKHVWXG\ZDVWRHVWLPDWHWKHHIIHFWVRIELVSKHQRO$;UD\VDQGFRPELQHGH[SRVXUHWR;UD\VDQG

bisphenol A on the induction of micronuclei in the peripheral blood and in bone marrow reticulocytes of laboratory mice.

0DWHULDODQGPHWKRG3]K6ILVPDOHPLFHZHUHH[SRVHGIRUZHHNV$QLPDOVZHUHWUHDWHGZLWKELVSKHQRO$GLOXWHGLQ

GULQNLQJZDWHU PJNJEZPJNJEZPJNJEZ LUUDGLDWHG*\RI;UD\VRUH[SRVHGWRDFRPELQDWLRQRI ERWK *\PJNJEZ%3$ 7KHVDPSOHVRISHULSKHUDOEORRGZHUHWDNHQDWDQGZHHNIROORZLQJWKHVWDUWRI H[SRVXUHZKHUHDVWKHERQHPDUURZDIWHUWKHHQGRIH[SHULPHQWRQO\7KHLQGXFWLRQRIPLFURQXFOHLLQUHWLFXORF\WHVZHUH evaluated by using fluorescence microscope.

5HVXOWV Bisphenol A as well as ionizing radiation stimulated induction of micronuclei in peripheral blood and bone marrow

UHWLFXORF\WHV$IWHUWKHLUUDGLDWLRQWKHOHYHORIPLFURQXFOHLLQFUHDVHGZKHUHDVDIWHUH[SRVXUHWR%3$GHFUHDVHGUHODWHGWR WLPHH[SLUHGIURPEHJLQQLQJRIH[SHULPHQW&RPELQHGH[SRVXUHRILRQL]LQJUDGLDWLRQDQGELVSKHQRO$LQGXFHGVLJQLILFDQWO\ higher frequency of micronuclei compared to the effect produced by BPA alone. The frequency of micronuclei in peripheral EORRGUHWLFXORF\WHVLQFUHDVHGGXULQJWKHH[SHULPHQW,QDOOJURXSVWKHVLJQLILFDQWO\ORZHULQGXFWLRQRIPLFURQXFOHLLQUHWLFX-ORF\WHVRIERQHPDUURZWKDQRISHULSKHUDOEORRGZHUHREVHUYHG7KHOHYHOVRIPLFURQXFOHLLQPLFHH[SRVHGWRDFRPELQDWLRQ of X-rays and BPA or to irradiation alone were slightly higher compared to those administered to BPA alone.

&RQFOXVLRQV%LVSKHQRO$LQGXFHGPLFURQXFOHLLQSHULSKHUDOEORRGDQGERQHPDUURZUHWLFXORF\WHV6XEFKURQLF%3$H[SR-sure leads to diminished sensitivity of genetic material of reticulocytes on the induction of damage. X-rays is probably the DJHQWZKLFKGHFLGHGDERXW'1$GDPDJHIROORZLQJFRPELQHGH[SRVXUH

:67ĉ3

:H ZVSyáF]HVQ\P ĞZLHFLH ]ZLą]NL FKHPLF]QH RUD] F]\QQLNL IL]\F]QH Z\VWĊSXMąFH Z ĞURGRZLVNX PRJąVWDQRZLü]DJURĪHQLHGODĞZLDWDURĞOLQ]ZLHU]ąW L F]áRZLHND -HGQą ] JUXS ]ZLą]NyZ SRZRGXMąF\FK QLHNRU]\VWQ\ZSá\ZQDNRPyUNLVVDNyZVąVXEVWDQFMH Z\ND]XMąFHSRGRELHĔVWZRGRHVWURJHQyZ-XĪZODWDFK WU]\G]LHVW\FK;;ZLHNX]QDQRVXEVWDQFMHĞURGRZLVNR-ZHNWyUHZVZRLPG]LDáDQLXSU]\SRPLQDá\QDWXUDOQ\ HVWURJHQȕHVWUDGLRO=ZLą]NLWHRNUHĞODVLĊMDNR NVHQRHVWURJHQ\ [HQR – obcy), czyli estrogeny pocho-G]HQLD]HZQĊWU]QHJR6XEVWDQFMHRG]LDáDQLXVáDE\FK HVWURJHQyZ ]QDOH]LRQR ]DUyZQR ZĞUyG ]ZLą]NyZ Z\WZRU]RQ\FKSU]H]F]áRZLHNDMDNLZĞUyG]ZLą]NyZ QDWXUDOQLHZ\VWĊSXMąF\FKZSU]\URG]LH>@=ZLą]NL HVWURJHQRSRGREQH PRJą ZFKRG]Lü Z VNáDG SURGXN-WyZSU]HP\VáRZ\FKNRPHUF\MQ\FKRUD]PHG\F]Q\FK LIDUPDFHXW\F]Q\FK>@6XEVWDQFMąWHJRW\SXMHVW ELVIHQRO$ %3$ NWyU\SRUD]SLHUZV]\]RVWDáRWU]\-PDQ\SU]H]URV\MVNLHJRFKHPLND'LDQLQDZURNX MDNRSURGXNWNRQGHQVDFMLDFHWRQXLGZyFKF]ąVWHF]HN IHQROX-HVW]ZLą]NLHPRUJDQLF]Q\PUD]\PQLHM DNW\ZQ\PQLĪȕHVWUDGLROLUD]\PQLHMDNW\Z-Q\PQLĪV\QWHW\F]Q\KRUPRQGLHW\ORVWLOEHVWURO '(6  NWyUHJRSU]\SRPLQDEXGRZą>@%3$VWDQRZLIRUPĊ V\QWHW\F]QHJRHVWURJHQXFRR]QDF]DĪHZRUJDQL]PLH F]áRZLHNDPRĪHáąF]\üVLĊ]UHFHSWRUDPLRGSRZLHG]LDO-Q\PL]DZLą]DQLHQDWXUDOQHJRHVWURJHQX.VHQRHVWURJHQ WHQ]QDOD]á]DVWRVRZDQLHZSURGXNFMLSROLZĊJODQyZ RUD]Ī\ZLFHSRNV\GRZ\FKREDUG]RV]HURNLPVSHNWUXP ]DVWRVRZDQLDPLQZSURGXNFMLVRF]HZHNGRRNXODUyZ Z\SHáQLHĔGHQW\VW\F]Q\FKSá\W&'V]\ERNLHQQ\FK SRNU\ZLQVWUXPHQWyZRSDNRZDĔRUD]SRMHPQLNyZQD QDSRMHDOHWDNĪHZ\UREyZGODG]LHFLEXWHOHNWDOHU]\-NyZNXEHF]NyZRUD]HOHPHQWyZVPRF]NyZĩ\ZLFH HSRNV\GRZHZFKRG]ąZVNáDGSRZáRNZHZQĊWU]Q\FK SRMHPQLNyZGRSU]HFKRZ\ZDQLDĪ\ZQRĞFL=ZLą]HN WHQXĪ\ZDQ\MHVWUyZQLHĪZSU]HP\ĞOHVDPRFKRGRZ\P RUD]SU]\Z\WZDU]DQLXVSU]ĊWXPHG\F]QHJRLZ\UREyZ GODVSRUWRZFyZ>@ 3URPLHQLRZDQLHMRQL]XMąFHZ\ZRáXMHZRUJDQL]PLH VNXWNL QD SR]LRPLH PROHNXODUQ\P L NRPyUNRZ\P :UDĪOLZRĞü NRPyUHN QD SURPLHQLRZDQLH ]DOHĪ\ RG ZLHOXF]\QQLNyZPLQRGID]\F\NOXNRPyUNRZHJR ZNWyUHMVLĊ]QDMGXMąZPRPHQFLHHNVSR]\FML']LDáD-QLHSURPLHQLRZDQLDMRQL]XMąFHJRQDWNDQNLRSLHUDVLĊ QDGZyFKPHFKDQL]PDFKEH]SRĞUHGQLPLSRĞUHGQLP 2ED PHFKDQL]P\ VNXWNXMą ]PLDQDPL FKHPLF]Q\PL SU]HU\ZDQLH ZLą]DĔ GHSROLPHU\]DFMD SROLPHU\]D-cja) oraz biochemicznymi (zaburzenia syntezy DNA L51$]DKDPRZDQLHV\QWH]\$73LQQH]PLDQ\HQ]\- PDW\F]QH 3RZ\ĪV]H]PLDQ\IL]\NRFKHPLF]QHSRZR-GXMąRNUHĞORQHHIHNW\ELRORJLF]QH]DOHĪQHRGGDZNL SURPLHQLRZDQLD0RĪHWRSURZDG]LüGRXSRĞOHG]HQLD F]\QQRĞFLUHSURGXNF\MQ\FK SRG]LDáyZ NRPyUNLOXE ZSá\ZDüQDSURFHV\PHWDEROLF]QH1LHSUDZLGáRZRĞFL ZSURFHVLHSRG]LDáyZNRPyUNLPRJąE\üVSRZRGR-ZDQH XV]NRG]HQLHP FKURPRVRPyZ RSyĨQLHQLHP PLWRW\F]Q\P SU]HVXQLĊFLHP Z F\NOX NRPyUNRZ\P OXEPXWDFMDPL>@ &HOHPEDGDĔE\áRRNUHĞOHQLHW\JRGQLRZHJRZSá\-ZXELVIHQROX$SURPLHQLRZDQLD;RUD]VNRMDU]RQHJR G]LDáDQLDREXW\FKF]\QQLNyZQDF]ĊVWRĞüZ\VWĊSR-ZDQLDPLNURMąGHUZUHWLNXORF\WDFKNUZLREZRGRZHM LV]SLNXNRVWQHJRVDPFyZP\V]\ 0$7(5,$à,0(72'$

Badania przeprowadzono na 8-tygodniowych sam-FDFK P\V]\ ODERUDWRU\MQ\FK QLHNUHZQLDF]HJR VWDGD

(3)

,QGXNFMDPLNURMąGHUXP\V]\QDUDĪDQ\FKQDG]LDáDQLHSURPLHQLRZDQLD;LELVIHQROX$ 19 Nr 1

3]K 6ILV =ZLHU]ĊWD SU]HE\ZDá\ Z SRPLHV]F]HQLX ] DXWRPDW\F]QLH UHJXORZDQ\P F\NOHP ĞZLHWOQ\P RVWDáHMWHPSHUDWXU]HLZLOJRWQRĞFL6DPFHSRGGDZDQR G]LDáDQLXSURPLHQLRZDQLD;LOXEELVIHQROX$UR]SXV]-F]RQHJRZQLHZLHONLHMLORĞFLHWDQROXDQDVWĊSQLH UR]FLHĔF]DQHJRGRRGSRZLHGQLHMGDZNLZZRG]LHGR SLFLD0\V]\HNVSRQRZDQRQDREDF]\QQLNLSU]H] W\JRGQL1DSU]HSURZDG]HQLHEDGDĔX]\VNDQR]JRGĊ ,9/RNDOQHM.RPLVML(W\F]QHMZ:DUV]DZLH 'DZNDSURPLHQLRZDQLD;Z\QRVLáD*\'DZNL ELVIHQROX$Z\QRVLá\PJNJPFPJNJPFLPJ NJPF:SU]\SDGNXVNRMDU]RQHJRG]LDáDQLD]DVWRVRZDQR GDZNL*\PJNJ%3$ħUyGáHPSURPLHQLRZDQLD E\áWHUDSHXW\F]Q\DSDUDWUHQWJHQRZVNL7+;ILUP\ 0HGLFRU3RGF]DVSUDF\VWRVRZDQRQDWĊĪHQLHSUąGX N9QDSLĊFLHP$ILOWUDFMDGRGDWNRZDPP&X ZDUVWZDSRáyZNRZDPP&X0RFGDZNLZ\QRVLáD *\PLQQDFDáHFLDáR3RXSá\ZLHLW\JRGQLRG UR]SRF]ĊFLDHNVSR]\FMLP\V]RPSRELHUDQRNUHZ]Ī\á\ RJRQRZHM6]SLNNRVWQ\SRELHUDQRW\ONRSR]DNRĔF]HQLX ±W\JRGQLRZHJRQDUDĪDQLD2GNDĪGHJRVDPFDSRELHUDQR po 10PONUZLREZRGRZHM]Ī\á\RJRQRZHMQDQRV]RQR QDV]NLHáNDPLNURVNRSRZHSRNU\WHZRGQ\PUR]WZRUHP RUDQĪXDNU\G\Q\LSU]\NU\ZDQRV]NLHáNLHPQDNU\ZNR-Z\P:FHOXSR]\VNDQLDV]SLNXNRVWQHJRL]RORZDQR NRĞüXGRZąDNDQDáV]SLNRZ\SU]HSáXNLZDQRVXURZLFą SáRGRZąFLHOĊFą=DZLHVLQĊRGZLURZ\ZDQRSRXVXQLĊ-FLXQDGPLDUXVXSHUQDWDQWX]DZDUWRĞüSUREyZNLGRNáDGQLH PLHV]DQR1DVWĊSQLHQDV]NLHáNRPLNURVNRSRZHSRNU\WH ZRGQ\PUR]WZRUHPRUDQĪXDNU\G\QRZHJRQDQRV]RQR SRPORWU]\PDQHM]DZLHVLQ\NRPyUHNLSU]\NU\ZDQR V]NLHáNLHPQDNU\ZNRZ\P2FHQ\LQGXNFMLPLNURMąGHU ZNUZLREZRGRZHMLV]SLNXNRVWQ\PGRNRQDQRZHGáXJ metody opisanej przez +D\DVKLLZVS>@&]ĊVWRĞü Z\VWĊSRZDQLDPLNURMąGHUZUHWLNXORF\WDFKNUZLREZR-GRZHMLV]SLNXNRVWQHJRRFHQLDQRSRGPLNURVNRSHP IOXRUHVFHQF\MQ\P]OLF]DMąFSRUHWLNXORF\WyZ]NDĪ-GHMP\V]\LUHMHVWUXMąFUyZQRF]HĞQLHOLF]EĊNRPyUHN ]PLNURMąGUDPL 01  $QDOL]\VWDW\VW\F]QHMGRNRQDQR]DSRPRFąWHVWX t-6WXGHQWD w programie Statistica 9. :<1,., :WDEHOLSU]HGVWDZLRQRZ\QLNLGRW\F]ąFHLQGXNFML PLNURMąGHUZUHWLNXORF\WDFKNUZLREZRGRZHMLV]SLNX NRVWQHJRVDPFyZP\V]\ 3RW\JRGQLXHNVSR]\FMLQDELVIHQRO$F]ĊVWRĞü Z\VWĊSRZDQLDPLNURMąGHUZ]UDVWDáDOLQLRZRZ]DNUH-VLHGDZHNRGGRPJNJPFDSR]DVWRVRZDQLX QDMZ\ĪV]HMGDZNLRVLąJQĊáDZDUWRĞüSRQDGNURWQLH Z\ĪV]ąQLĪXVDPFyZNRQWUROQ\FK:V]\VWNLHZ\QLNL RSUyF]X]\VNDQ\FKSRSRGDZDQLXPJNJPF%3$ UyĪQLá\VLĊVWDW\VW\F]QLHRGNRQWUROQ\FK3RW\JR-GQLDFKSRGDZDQLDELVIHQROX$QDMZLĊNV]ąOLF]HEQRĞü UHWLNXORF\WyZ]PLNURMąGUDPLX]\VNDQRGODGDZNL PJNJPFQLHFRPQLHMV]ąGODGDZNLPJNJPF%3$ DQDMPQLHMV]ąSRQRZQLHGODGDZNLPJNJPF%3$ :V]\VWNLH Z\QLNL E\á\ LVWRWQH VWDW\VW\F]QLH RSUyF] X]\VNDQ\FKSRHNVSR]\FMLQD%3$ZGDZFHPJNJ PF3RW\JRGQLRZ\PQDUDĪDQLXQD%3$QDMZ\ĪV]ą OLF]HEQRĞüUHWLNXORF\WyZX]\VNDQRGODGDZNLPJNJ PFLW\ONRQLHFRQLĪV]ąGODGDZNLPJNJPF%3$ :V]\VWNLH Z\QLNL UyĪQLá\ VLĊ QLH]QDF]QLH RG VLHELH LĪDGQDZDUWRĞüQLHUyĪQLáDVLĊVWDW\VW\F]QLHRGNRQWUR-OQHM'ODGDZNLPJNJPF%3$REVHUZRZDQRZ]URVW LQGXNFMLPLNURMąGHUZUD]]F]DVHPQDUDĪDQLDQDWRPLDVW GODGDZHNPJNJPFLPJNJPFREVHUZRZDQR VSDGHNLQGXNFMLPLNURMąGHUZNROHMQ\FKW\JRGQLDFK WUZDQLDGRĞZLDGF]HQLD :QDVWĊSVWZLHQDSURPLHQLDQLD]ZLHU]ąWSURPLH-QLRZDQLHP;LQGXNFMDPLNURMąGHUZ]UDVWDáDZ\UDĨQLH LSURSRUFMRQDOQLHGRF]DVXWUZDQLDHNVSR]\FMLDSR  W\JRGQLDFK RVLąJQĊáD QDMZLĊNV]ą ZDUWRĞü:\QLNL E\á\LVWRWQHVWDW\VW\F]QLHZVWRVXQNXGRNRQWUROL3R W\JRGQLXQDSURPLHQLDQLDGDZNą*\RGQRWRZDQR SRQDGNURWQ\Z]URVWF]ĊVWRĞFLZ\VWĊSRZDQLD01 7DEHOD&]ĊVWRĞüZ\VWĊSRZDQLDPLNURMąGHUZUHWLNXORF\WDFKVDPFyZP\V]\ZQDVWĊSVWZLHLW\JRGQLRZHMHNVSR]\FML QDELVIHQRO$OXELQDSURPLHQLRZDQLHMRQL]XMąFH  )UHTXHQF\RIPLFURQXFOHLLQPDOHPLFHUHWLFXORF\WHVIROORZLQJDQGZHHNVH[SRVXUHWR;UD\VRUDQGEL-sphenol A

'DZND 01UHWLNXORF\WyZZNUZLREZRGRZHMr SD WyZZV]SLNXNRVWQ\P 01UHWLNXORF\-r SD Po 1 tygodniu 3RW\JRGQLDFK Po 8 tygodniach Kontrola PJ%3$ 10 mg BPA PJ%3$ *\ *\PJ%3$ r 7.80r r r r r , b r r 11.00r 10.00r r r , b r 9.80r r r r r r r r r r r SUyĪQLFHVWDW\VW\F]QLHLVWRWQHZVWRVXQNXGRNRQWUROLZWHĞFLHW6WXGHQWD ESUyĪQLFHVWDW\VW\F]QLHLVWRWQHZVWRVXQNXGRNRQWUROLLGRELVIHQROX$ZWHĞFLHW6WXGHQWD

(4)

-5DG]LNRZVND$*DMRZLN0'REU]\ĔVND  Nr 1 DSRW\JRGQLDFKHNVSR]\FMLREVHUZRZDQRZWHMJUX-SLHSRQDGNURWQLHZLĊFHMPLNURMąGHUZVWRVXQNXGR ZDUWRĞFLNRQWUROQHM 6NRMDU]RQHG]LDáDQLHSURPLHQLRZDQLD;LELVIHQROX $ZNUZLREZRGRZHMUyZQLHĪSRZRGRZDáRZ]URVW F]ĊVWRĞFL Z\VWĊSRZDQLD PLNURMąGHU ZUD] ] F]DVHP WUZDQLDHNVSR]\FML&]ĊVWRĞüWDE\áDZLĊNV]DQLĪSR podawaniu samego BPA, ale mniejsza w porównaniu ]HIHNWDPLG]LDáDQLDVDPHJRSURPLHQLRZDQLD;SU]H] FDá\RNUHVWUZDQLDGRĞZLDGF]HQLD :UHWLNXORF\WDFKV]SLNXNRVWQHJRLQGXNFMDPLNUR-MąGHUSRHNVSR]\FMLQD%3$E\áDQDMZLĊNV]DGODGDZNL PJNJPFDOHW\ONRQLH]QDF]QLHPQLHMV]DGODGDZNL PJNJPF%3$:REXSU]\SDGNDFKZDUWRĞFLE\á\ SRQDGNURWQLHZ\ĪV]HZSRUyZQDQLXGRNRQWUROQ\FK 3RSRGDZDQLXP\V]RPELVIHQROX$ZGDZFHPJ NJPFREVHUZRZDQRQDMPQLHMV]ąLQGXNFMĊPLNURMąGHU 7\ONRZ\QLNX]\VNDQ\SRHNVSR]\FMLQDPJNJPF %3$UyĪQLáVLĊVWDW\VW\F]QLHZVWRVXQNXGRNRQWUROL3R QDUDĪDQLXQDSURPLHQLRZDQLHMRQL]XMąFHREVHUZRZDQR ZLĊNV]ą LORĞü PLNURMąGHU QLĪ SR HNVSR]\FML QD VDP ELVIHQRO$ 3RGREQH Z QDVWĊSVWZLH W\JRGQLRZHM HNVSR]\FMLQDREDF]\QQLNLOLF]HEQRĞüPLNURMąGHUE\áD Z\ĪV]DQLĪSR]DVWRVRZDQLXVDPHJR%3$3RVDP\P QDSURPLHQLDQLX]ZLHU]ąWRUD]SRHNVSR]\FMLQDVNR-MDU]RQHG]LDáDQLHSURPLHQLRZDQLD;L%3$X]\VNDQR Z\QLNLQLH]QDF]QLHUyĪQLąFHVLĊRGVLHELHDOHUyĪQLąFH VLĊVWDW\VW\F]QLHRGNRQWUROL '<6.86-$ =HZ]JOĊGXQDV]HURNLHVSHNWUXPXPLHMVFRZLHQLD UHFHSWRUyZHVWURJHQRZ\FKNVHQRHVWURJHQ\VąZVWDQLH Z\ZRá\ZDüG]LDáDQLDQLHSRĪąGDQHQLHPDOZHZV]\VW-NLFKWNDQNDFKLQDU]ąGDFK>@=ZLą]NLRDNW\ZQRĞFL HVWURJHQQHMPRJą]DEXU]DüSUDZLGáRZ\UR]G]LDáFKUR- PRVRPyZSRGF]DVPHMR]\>@2F]ĊVWRĞFLSRZVWD-ZDQLDPLNURMąGHUZNRPyUNDFKVRPDW\F]Q\FKVVDNyZ GHF\GXMHZGXĪ\PVWRSQLXF]DVG]LDáDQLD]ZLą]NX>@ 1DV]HEDGDQLDZ\ND]Dá\ĪHQDMZLĊFHMPLNURMąGHUSR-ZVWDáRSRW\JRGQLXHNVSR]\FMLQDELVIHQRO$GODGDZNL PJNJPF'ODWHJRSXQNWXF]DVRZHJRREVHUZRZDQR WDNĪHZ]URVWLQGXNFML01ZUD]]]DVWRVRZDQąGDZNą =GDQLDGRW\F]ąFHZSá\ZXELVIHQROX$QDNRPyUNL VRPDW\F]QHRUJDQL]PyZĪ\Z\FKVąSRG]LHORQH1LHNWy-U]\DXWRU]\Z\ND]DOLĪH%3$QLHLQGXNXMHPLNURMąGHU ZV]SLNXNRVWQ\P>@LQQLQDWRPLDVWZVND]XMą QDZ\UDĨQąLQGXNFMĊ01SU]H]WHQNVHQRHVWURJHQ> @1DLNLZVS>@GRQRV]ąĪHELVSKHQRO$QLH Z\ZRáXMHDEHUUDFMLFKURPRVRPRZ\FKLSRZVWDZDQLD PLNURMąGHUZNRPyUNDFKV]SLNXNRVWQHJRP\V]\6ZLVV-DOELQRDOHSRWHQFMDOQąJHQRWRNV\F]QRĞüWHJR]ZLą]NX ]DREVHUZRZDQR Z HIHNFLH FPLWR]\ L SRZVWDZDQLD DFKURPDW\F]Q\FKOXN3RQDGWRDXWRU]\FLSRGDMąĪH

w badaniach cytogenetycznych LQYLWURbisfenol A nie ZSá\Qąá]QDF]ąFRQDDEHUUDFMHFKURPRVRPRZHSRQLH- ZDĪQLHMHVWRQNODVWRJHQQ\ZNRPyUNDFKV]SLNXNRVW-nego LQYLYR%3$LQGXNRZDáSRZVWDZDQLHPLNURMąGHU ZNXOWXUDFKNRPyUHN9FKRPLNDFKLĔVNLHJR>@ 0RĪQDSU]\SXV]F]DüĪH%3$PRĪHLQGXNRZDüSRZVWD-ZDQLHDQHXSORLGyZZZ\QLNXQRQG\VMXQNFMLSRGF]DV PLWR]\>@0RĪHSURZDG]LüWRGRPXWDFMLFKURPRVR-PRZ\FKDWH]NROHLGRNDQFHURJHQH]\,]RWWL i wsp. >@SRWZLHUG]DMą]GROQRĞü%3$GRWZRU]HQLDDGGXNWyZ '1$LQYLWURRUD]LQYLYRZZąWURELHP\V]\3RGREQLH Yoo LZVS>@SRGDMąĪHGRXVWQHSRGDZDQLHP\V]RP ELVIHQROX$SURZDG]LGRWZRU]HQLDDGGXNWyZZ'1$ NRPyUHNQDEáRQNRZ\FK%3$LQGXNRZDáWDNĪHOLF]QH zmiany chromosomowe, transformacje morfologiczne, DQHXSORLG\LUyZQLHĪDGGXNW\Z'1$>@ 7DNĪHSRFKRGQHELVIHQROX$Z\VWĊSXMąFHZVWRPD-WRORJLF]Q\FKPDWHULDáDFK]áRĪRQ\FKPLQPHWDNU\ODQ ELVIHQROX$ %LV*0$  PRJą SURPRZDü PXWDFMH LQLHVWDELOQRĞüJHQRPRZą>@3RZRGXMąRQH]QDF]QH ]ZLĊNV]HQLHF]ĊVWRĞFLSRMHG\QF]RQLFLRZ\FKSĊNQLĊü Z'1$OLPIRF\WyZNUZLREZRGRZHMRUD]ZNRPyUNDFK JUXF]RáyZĞOLQRZ\FK>@ 6FKZHLNOLZVS>@ GRQRV]ąĪHPLQ%LV*0$PDZSá\ZQDSRZVWDZDQLH ]ZLĊNV]RQHMOLF]E\PLNURMąGHURUD]PRVWNyZQXNOHRSOD- ]PDW\F]Q\FKFRPRĪHZVND]\ZDüĪH]ZLą]NLWHLQGX-NXMąSU]HUZ\ZFKURPRVRPDFKRUD]LFKUHDUDQĪDFMHInni DXWRU]\Z\ND]DOLĪHPHWDNU\ODQELVIHQROX$SRZRGXMH GHOHFMĊZJHQRPLHNRPyUHNVVDNyZNWyUDPRJáDQDVWą-SLüZZ\QLNXSRGZyMQR±QLFLRZ\FKSĊNQLĊüZ'1$ NWyUH]NROHLSURZDG]ąGRDEHUUDFMLFKURPRVRPRZ\FK >@6FKZHLNOLZVS>@SRGDMąWDNĪHĪHEDUG]RQLVND DNW\ZQRĞü%LV*0$LZ\NU\WDOLF]EDPLNURMąGHUSR HNVSR]\FMLQDZ\VRNLHVWĊĪHQLH%LV*0$L%3$E\á\ ]ZLą]DQH]F\WRWRNV\F]QRĞFLą'UR]GLZVS>@SURZD-G]LOLEDGDQLDQDOLPIRF\WDFKF]áRZLHNDLZ\ND]DOLĪH %LV*0$MHVWZVWDQLHLQGXNRZDüV]HURNLHVSHNWUXP XV]NRG]HĔ'1$ZOLF]DMąFSĊNQLĊFLDSRGZyMQHMKHOLV\ 8V]NRG]HQLDWHPRJąE\üRGSRZLHG]LDOQH]DRSyĨQLHQLH F\NOXNRPyUNRZHJRZID]LH6-HGQDN$URVVLLZVS>@ SRGDMąĪHPHWDNU\ODQELVIHQROX$QLHZ\ND]XMHHIHNWX JHQRWRNV\F]QHJR:QLQLHMV]\FKEDGDQLDFKZ\ND]DQR ĪHW\JRGQLRZHQDUDĪDQLHQDELVIHQRO$LQGXNXMHSR-ZVWDZDQLHPLNURMąGHU]DUyZQRZUHWLNXORF\WDFKNUZL REZRGRZHMMDNLV]SLNXNRVWQHJR0LNURMąGUDWHPRJą E\ü]DUyZQRHIHNWHPSĊNDQLDFKURPRVRPyZMDNLQLH ZáąF]DQLDFDá\FKFKURPRVRPyZGRMąGHUNRPyUHNSR- WRPQ\FK:UD]]XSá\ZHPF]DVXRGUR]SRF]ĊFLDHNVSR- ]\FMLQD%3$ZGDZNDFKPJNJLPJNJPFREVHU-ZRZDQR]QDF]QH]PQLHMV]HQLHF]ĊVWRĞFLZ\VWĊSRZDQLD PLNURMąGHU0RĪHWRĞZLDGF]\üRDGDSWDFMLRUJDQL]PX GR]ZLĊNV]RQHMHNVSR]\FMLQDELVIHQRO$ZZDUXQNDFK subchronicznych. :SLĞPLHQQLFWZLHMHVWZLHOHGRQLHVLHĔRJHQRWRN-V\F]Q\P G]LDáDQLX SURPLHQLRZDQLD MRQL]XMąFHJR QD

(5)

,QGXNFMDPLNURMąGHUXP\V]\QDUDĪDQ\FKQDG]LDáDQLHSURPLHQLRZDQLD;LELVIHQROX$  Nr 1 NRPyUNLVRPDW\F]QHVVDNyZ1DV]HEDGDQLDZ\UDĨQLH ZVND]XMąQDZ]URVWLQGXNFMLPLNURMąGHUZUD]]F]DVHP VXEFKURQLF]QHMHNVSR]\FMLVDPFyZP\V]\QDSURPLH-niowanie X. 6DEDWLLZVS>@SRGDMąĪHXRVyEQDUD-ĪRQ\FK]DZRGRZRQDSURPLHQLRZDQLH; SUDFRZQLF\ V]SLWDOLZVHNFMLUDGLRORJLLRUD]REVáXJXMąF\XU]ąG]HQLD ZHOHNWURZQLDFKMąGURZ\FK REVHUZRZDQRDEHUUDFMH FKURPRVRPRZH PLNURMąGUD L Z\PLDQĊ FKURPDW\G VLRVWU]DQ\FKZOLPIRF\WDFKNUZLREZRGRZHM:XELH-Já\FKODWDFKZQDV]HMSUDFRZQLZ\ND]DQRĪHXP\V]\ QDSURPLHQLDQ\FK PDá\PL GDZNDPL SURPLHQLRZDQLD MRQL]XMąFHJR *\ Z\VWĊSXMH]ZLĊNV]RQDOLF]ED PLNURMąGHUZHU\WURF\WDFKSROLFKURPDW\F]Q\FKLUHWL-NXORF\WDFKV]SLNXNRVWQHJR1DWRPLDVWW\JRGQLRZD HNVSR]\FMDP\V]\QDWHVDPHGDZNLSURPLHQLRZDQLD MRQL]XMąFHJRLQGXNXMHSRZVWDZDQLHPLNURMąGHUZHU\-WURF\WDFKV]SLNXNRVWQHJR]ZLĊNV]ąF]ĊVWRWOLZRĞFLą QLĪ VXEFKURQLF]QH W\JRGQLRZH QDUDĪDQLH ]ZLHU]ąW >@+DPDVDNLLZVS>@ZVND]XMąĪHQDZHWSRURNX HNVSR]\FMLQDSURPLHQLRZDQLH;ZGDZFH*\RE-VHUZRZDQR]ZLĊNV]HQLHF]ĊVWRWOLZRĞFLZ\VWĊSRZDQLD PLNURMąGHUZUHWLNXORF\WDFKNUZLREZRGRZHM0RĪH WRĞZLDGF]\üRSU]HGáXĪRQ\PHIHNFLHG]LDáDQLDSUR-PLHQLRZDQLDQDXNáDGNUZLRWZyUF]\&DUUHUD i wsp. >@VWZLHUG]LOLLVWRWQ\SR]LRPXV]NRG]HQLD'1$ZNR-PyUNDFKZąWURE\P\V]\VSRZRGRZDQHJRMHGQRUD]RZą HNVSR]\FMąQDPDáHGDZNLSURPLHQLRZDQLD; *\ L*\ 3URPLHQLRZDQLH;ZGDZFH*\SRZRGXMH ZNRPyUNDFKGLSORLGDOQ\FKRNMHGQRQLFLRZ\FK LSRGZyMQRQLFLRZ\FKSĊNQLĊü'1$>@ 2EHFQLHZSLĞPLHQQLFWZLHMHVWQLHZLHOHGDQ\FKQD WHPDWVNRMDU]RQHJRG]LDáDQLDSURPLHQLRZDQLD;LELV-IHQROX$QDNRPyUNLVRPDW\F]QH:QLQLHMV]HMSUDF\ Z\ND]DQRĪHVNRMDU]RQHG]LDáDQLHSURPLHQLRZDQLD; LELVIHQROX$ZSá\ZDáRQD]PQLHMV]HQLHLQGXNFMLPLNURMą- GHUZSRUyZQDQLXGRHNVSR]\FMLQDVDPRSURPLHQLRZD-QLH;QDWRPLDVWSU]HZ\ĪV]DáRZDUWRĞFLRWU]\PDQHW\ONR SRG]LDáDQLXELVIHQROX$W\JRGQLRZHVXEFKURQLF]QH QDUDĪDQLHVSRZRGRZDáRZLĊNV]ąLQGXNFMĊPLNURMąGHUQLĪ W\JRGQLRZHQDUDĪDQLH1LHFRLQQHUH]XOWDW\RWU]\PDQR ZF]HĞQLHMZQDV]HMSUDFRZQLZF]DVLHW\JRGQLRZHM HNVSR]\FML QD SURPLHQLRZDQLH ; L %3$ GOD PDá\FK GDZHN:\ND]DQRZyZF]DVLQGXNFMĊPLNURMąGHU]F]Ċ-VWRĞFLąZLĊNV]ąQLĪSRG]LDáDQLXNDĪGHJR]F]\QQLNyZ oddzielnie. Natomiast w tych samych badaniach, ale dla ZLĊNV]\FKGDZHNF]ĊVWRĞüZ\VWĊSRZDQLDPLNURMąGHUSR VNRMDU]RQ\PG]LDáDQLXREX]ZLą]NyZE\áDMXĪ]QDF]-QLHZ\ĪV]DQLĪSRHNVSR]\FMLQDVDP%3$>@:Sá\Z VNRMDU]HQLDELVIHQROX$LMHJRSRFKRGQ\FKIRUPRUD] promieniowania ultrafioletowego badali 0XWRX i wsp. >@'RQRV]ąRQLĪHFKORURELVIHQRO$¶GLFKOR-URELVIHQRO$RUD]¶WULFKORURELVIHQRO$ &,%3$V  Z\VWDZLRQH QD G]LDáDQLH 89% L 89& ZSá\ZDá\ QD ]ZLĊNV]HQLHĞPLHUWHOQRĞFLNRPyUHNOXG]NLFKOLPIRF\WyZ SUDZGRSRGREQLHZQDVWĊSVWZLHNRQGHQVDFMLFKURPDW\-Q\LIUDJPHQWDFML'1$1DWRPLDVWQDUDĪDQLHQD89$ L%3$QLHSRZRGRZDáR]QDF]ąFHJRZSá\ZXQDSURFHV DSRSWR]\,QQHEDGDQLDVXJHUXMąĪHHNVSR]\FMDQD89% PRĪHREQLĪDüDNW\ZQRĞüHVWURJHQQą%3$L&,%3$V>@ :XELHJá\FKODWDFKZ=DNáDG]LH2FKURQ\5DGLRORJLF]QHM L 5DGLRELRORJLL 1DURGRZHJR ,QVW\WXWX =GURZLD 3X-EOLF]QHJR3DĔVWZRZHJR=DNáDGX+LJLHQ\SURZDG]RQR EDGDQLDQDGZSá\ZHPSURPLHQLRZDQLDMRQL]XMąFHJR LQRQ\OIHQROX 1) NWyU\WDNĪHQDOHĪ\GR]ZLą]NyZ RDNW\ZQRĞFLHVWURJHQQHM'RZLHG]LRQRZQLFKĪHW\- JRGQLRZDHNVSR]\FMDQDVNRMDU]RQHG]LDáDQLHSURPLH-QLRZDQLD;LQRQ\OIHQROXZPQLHMV]\FKGDZNDFK  *\PJNJPF1) SRZRGXMHZLĊNV]ąOLF]HEQRĞü PLNURMąGHUZUHWLNXORF\WDFKV]SLNXNRVWQHJRVDPFyZ P\V]\QLĪ]DVWRVRZDQLHREXF]\QQLNyZZZLĊNV]\FK GDZNDFK *\PJNJPF1) >@:\QLNLLQQHM SUDF\Z\ND]Dá\VW\PXOXMąFHG]LDáDQLHUyZQRF]HVQHJR ]DVWRVRZDQLDSURPLHQLRZDQLD;LQRQ\OIHQROXSRW\JR-GQLRZHMHNVSR]\FMLZPQLHMV]\FKGDZNDFKQDWZRU]HQLH VLĊPLNURMąGHU-HGQDNUyZQRF]HVQHQDUDĪHQLH]ZLHU]ąW QDZ\ĪV]HGDZNLREXF]\QQLNyZWDNĪHSRZRGRZDáR ]PQLHMV]HQLHF]ĊVWRĞFLZ\VWĊSRZDQLDPLNURMąGHUFR PRĪHZVND]\ZDüQDRFKURQQHZáDĞFLZRĞFLQRQ\OIHQROX ZVWRVXQNXGRPXWDJHQQHJRG]LDáDQLDSURPLHQLRZDQLD MRQL]XMąFHJR>@:\QLNLX]\VNDQHZQLQLHMV]HMSUDF\ VXJHUXMąSRGREQHZáDĞFLZRĞFLELVIHQROX$V]F]HJyOQLH ZQDVWĊSVWZLHGáXJRWUZDáHMHNVSR]\FML :1,26.,  %LVIHQRO$SRZRGXMHXV]NRG]HQLHPDWHULDáXJHQH-W\F]QHJRUHWLNXORF\WyZNUZLREZRGRZHMLV]SLNX NRVWQHJRVDPFyZP\V]\ODERUDWRU\MQ\FK

 6XEFKURQLF]QH QDUDĪHQLH QD %3$ SURZDG]L GR ]PQLHMV]HQLDZUDĪOLZRĞFLPDWHULDáXJHQHW\F]QHJR UHWLNXORF\WyZQDLQGXNFMĊXV]NRG]HĔ  6NRMDU]RQHG]LDáDQLHSURPLHQLRZDQLD;LELVIHQROX $QLZHORZDáRXV]NRG]HQLHPDWHULDáXJHQHW\F]QHJR ZUHWLNXORF\WDFKZVWRVXQNXGRQDUDĪHQLDQDVDPR SURPLHQLRZDQLHMRQL]XMąFH  3URPLHQLRZDQLH;MHVWSUDZGRSRGREQLHF]\QQLNLHP GHF\GXMąF\PRXV]NRG]HQLX'1$ZQDVWĊSVWZLH VNRMDU]RQHJRG]LDáDQLD 3,ĝ0,(11,&7:2 1. $URVVL*$/HKPDQQ0'LKO555HJXO\00GH

$QGUDGH++Induced DNA damage by dental resin

monomers in somatic cells. Basic. Clin. Pharmacol. 7R[LFRO±

 &DUUHUD 3 GH 0LJXHO 0 /RSH] - GH OD 7RUUH &

1DYDUUHWH0+,QYLYRresponse of mouse liver to

J-UDGLDWLRQDVVHVVHGE\WKHFRPHWDVVD\0XWDW5HV 

(6)

-5DG]LNRZVND$*DMRZLN0'REU]\ĔVND

 Nr 1

 &KRL60<RR6'/HH%07R[\FRORJ\&KDUDFWHULVWLF of the Endorcine-Disrupting Chemicals: Development 7R[LFLW\&DUFLQRJHQLFLW\DQG0XWDJHQLFLW\-7R[LFRO (QYLURQ+HDOWK3DUW%±

 &]DMND 8 'REU]\ĔVND 00 ,QGXNFMD PLNURMąGHU ZNRPyUNDFKVRPDW\F]Q\FKP\V]\HNVSRQRZDQ\FKQD G]LDáDQLHSURPLHQLRZDQLD;OXEQRQ\OIHQROXRUD]QD VNRMDU]RQHG]LDáDQLHREXF]\QQLNyZ5RF]Q3=+ ±  &]XSU\ĔVND.0DUFKOHZLF]0:LV]QLHZVND%:Sá\Z NVHQRHVWURJHQyZQDPĊVNLXNáDGSáFLRZ\3RVWĊS\ELR-ORJLLNRPyUNL7RP±  'REU]\ĔVND 00 5DG]LNRZVND - &]ĊVWRĞü Z\VWĊ-SRZDQLDPLNURMąGHUZUHWLNXORF\WDFKVDPFyZP\V]\ QDUDĪDQ\FKQDELVIHQRO$RUD]QDVNRMDU]RQHG]LDáDQLH SURPLHQLRZDQLD;LELVIHQROX$5RF]Q3=+ 1U 7. 'REU]\ĔVND 00 2FHQD F]ĊVWRĞFL Z\VWĊSRZDQLD PLNURMąGHUZHU\WURF\WDFKP\V]\HNVSRQRZDQ\FKVXE-FKURQLF]QLHQDSURPLHQLRZDQLHMRQL]XMąFHLQRQ\OIHQRO 5RF]Q3=+± 8. 'REU]\ĔVND008V]NRG]HQLDPDWHULDáXJHQHW\F]QH-JRNRPyUHNVRPDW\F]Q\FKP\V]\QDUDĪDQ\FKQDPDáH GDZNLSURPLHQLRZDQLD;5RF]Q3=+1U ± 9. 'UR]G.:\VRNLQVNL'.UXSD5:RĨQLDN. Bisphe-nol A-glycidyl metacrylate induced a broad spectrum of '1$LQKXPDQO\PSKRF\WHV$UFK7R[LFRO ±

10. 'XUQHU-, 'ĊELDN 0%UNOH+LFNHO55HLFKO). ,QGXFWLRQRI'1$VWUDQGEUHDNVE\GHQWDOFRPSRVLWH FRPSRQHQWVFRPSDUHGWR;UD\H[SRVXUHLQKXPDQJLQ-JLYDOILEUREODVWV$UFK7R[LFRO  ± 11. (YDQV+- Neoplasia and cytogenetic abnormalities, in.:

(WLRORJ\DQG0HFKDQLVPV%DVLF/LIH6FLHQFHV3OHQXP 3UHVV1HZ<RUN±

 +DLJKWRQ/$+O\ZND--'RXOO-.URHV5/\QFK

%60XQUR,& An evaluation of the possible

carci-QRJHQLFLW\RIELVSKHQRO$WRKXPDQV5HJXO7R[LFRO 3KDUPDFRO

 +DPDVDNL.,PDL.+D\DVKL71DNDFKL..XVRQRNL

<5DGLDWLRQVHQVLWLYLW\DQGJHQRPLFLQVWDELOLW\LQWKH

hematopoietic system: frequencies of micronucleated UHWLFXORF\WHV LQ ZKROHERG\ LUUDGLDWHG %$/%F DQG &%/PLFH&DQFHU6FL± 

+DUYH\$1&RVWD1'6DYDJH-57KDFNHU-Chro-mosomal aberrations induced by defined DNA double-VWUDQGEUHDNVWKHRULJLQRIDFKURPDWLFOHVLRQ6RPDW &HOOV0RO*HQHW±

 +D\DVKL00RULWD7.RGDPD<6RIXQL7,VKLGDWH

0-U The micronucleus assay with mouse peripheral

blood reticulocytes using acridine orange-coated slides. 0XWDW5HV±

 +XWWHUPDQQ-, 5RKLQJ0.RKQOHLQ: Free radicals from irradiated lyphilized DNA: influence of water on K\GUDWLRQ,QW-5DGLDW%LRO± 17. ,]]RWWL$.DQLW]6'¶$JRVWLQL)&DPRLUDQR$'H

)ORUD6Formation of adducts by bisphenol A, an

endo-crine disruptor, in DNA LQYLWURand in liver and mammary WLVVXHRIPLFH0XWDW5HV

18. -RKQVRQ*(3DUU\(0 Mechanistic investigations RIORZGRVHH[SRVXUHVWRWKHJHQRWR[LFFRPSRXQGVEL-VSKHQRO$DQGURWHQRQH0XWDW5HV± 19. .OHLQVDVVHU1+6FKPLG.6DVVHQ$+DUUHXV8$

6WDXGHQPDLHU5)ROZDF]Q\0*ODV-5HLFKO);

&\WRWR[LFDQGJHQRWR[LFHIIHFWRIUHVLQPRQRPHUVLQ human salivary gland tissue and lymphocytes as assessed by the single cell microgel electrophoresis (comet) assay. %LRPDWHULDOV±

 .OHLQVDVVHU1+:DOOQHU%&+DUUHXV8$.OHLQMXQJ

7)ROZDF]Q\0+LFNHO5.HKH.5HLFKO);Ge-QRWR[LFLW\DQGF\WRWR[LFLW\RIGHQWDOPDWHULDOVLQKXPDQ lymphocytes as assessed by the single cell microgel elec-WURSKRUHVLV FRPHW DVVD\-'HQW  0DUNH\&05XELQ%66RWR$06RQQHQVFKHLQ& Endorcine disruptors: from Wingrspread to environmen-tal development biology. J. Steroid Biochem. Mol. Biol. ±

 0DVXGD67HUDVKLPD<6DQR$.XUWR56XJL\DPD

<6KLPRL.7DQML.<RVKLRND+7HUDR<.LQDH 1 Changes In the mutagenie and estrogenie activities

RIELVSKHQRO$XSRQWUHDWPHQWZLWKQLWULWH0XWDW5HV 

 0HQGHV$-- The endorcine disrupters a major medical FKDOOHQJH)RRG&KHP7R[LFRO±  0XWRX<,

,EXNL<7HUDR<.RMLPD6*RWR5Chan-ge of estro,EXNL<7HUDR<.RMLPD6*RWR5Chan-genic activity and release of chloride ion in FKORULQDWHGELVSKHQRO$DIWHUH[SRVXUHWRXOWUDYLROHW% %LRO3KDUP%XOO±

 0XWRX<, ,EXNL<7HUDR<.RMLPD6*RWR5Induction RIDSRSWRVLVE\89LUUDGLDWHGFKORULQDWHGELVSKHQRO$LQ -XUNDWFHOOV7R[LFRO,Q9LWUR  1DLN39LMD\DOD[PL..Cytogenetic evaluation for

JHQRWR[LFLW\RI%LVSKHQRO$LQERQHPDUURZFHOOVRI 6ZLVVDOELQRPLFH0XWDW5HV  3DFFKLHURWWL)5DQDOGL5(LFKHQODXE±5LWWHU8$WWLD

6$GOHU,' Evaluation of aneugenic effects of

bisphe-QRO$LQVRQDWLFDQGJHUPFHOOVRIWKHPRXVH0XWDW5HV 

 3DZáRZVND (, /RED . %áDVLDN - 6]F]HSDĔVND - :áDĞFLZRĞFLLU\]\NRVWRVRZDQLDPHWDNU\ODQXELVIHQROX $LGLPHWDNU\ODQXXUHWDQX±SRGVWDZRZ\FKPRQRPHUyZ NRPSR]\WyZ VWRPDWRORJLF]Q\FK 'HQW 0HG 3UREO ±

 3IHLIIHU(5RVHQEHUJ%'HXVFKHO60HW]OHU0 Inter-ference with microtubules and induction of micronuclei LQYLWURE\YDULRXVELVSKHQROV0XWDW5HV ±  3U]\ERMHZVND%0HFKDQL]PLNLQHW\NDSRZVWDZDQLD PLNURMąGHUZV]SLNXNRVWQ\PP\V]\3RVW+LJ0HG 'RĞZ  6DEDWL.$/OR\G'&(GZDUGV$$6WHJQDU3A sur-vey of lymphocytes chromosomal damage in Slovenian YRUNHUVH[SRVHGWRRFFXSDWLRQDOFODVWRJHQ0XWDW5HV ±

 6FKZHLNO++LOOHU.$(FNKDUGW$%ROD\&.UHLVVO

0.UHLVPDQQ:1XVVHU$6WHLQKDXVHU6:LHF]RUHN - 9DVROG 5 6FKPDO] * &\WRWR[LF DQG PXWDJHQLF

HIIHFWRIGHQWDOFRPSRVLWHPDWHULDOV%LRPDWHLDOV ±

(7)

,QGXNFMDPLNURMąGHUXP\V]\QDUDĪDQ\FKQDG]LDáDQLHSURPLHQLRZDQLD;LELVIHQROX$  Nr 1

 6FKZHLNOO+6FKPDO]*5DFNHEUDQGW.The muta-genic activity of unpolymerized resin monomers in

6DO-PRQHOODW\SKLPXULXPDQG9FHOOV0XWDW5HV

±

 7VXWVXL77DPXUD<6X]XNL$+LURVH<.RED\DVKL

01LVKLPXUD+0HW]OHU0%DUUHWW-&

Mamma-lian cell transformation and aneuploidy induced by five ELVSKHQROV,QW-&DQFHU  ±  7VXWVXL77DPXUD<<DJL(+DVHJDZD.7DNDKDVKL

00DL]XPL1<DPDJXFKL)%DUUHWW-&

Bisphe-nol-A induces cellular transformation, aneuploidy and DNA adduct formation in cultured Syrian hamster em-EU\RFHOOV,QW-&DQFHU±

 7\O 5: 0\HUV &% 7KRPDV %) .HLPRZLW]$5

%ULQH'59HVHOLFD00)DLO3$&KDQJ7<6HHO\ -&-RLQHU5/%XWDOD-+'LPRQG66&DJHQ6= 7KUHH*HQHUDWLRQ5HSURGXFWLYH7R[LFLW\6WXG\RI'LH-WDU\%LVSKHQRO$LQ&'6SUDJXH'DZOH\5DWV7R[LFRO 6FL  <RR6'6KLQ%6/HH%0/HH.&+DQ6<.LP +6%LRDYDLODELOLW\DQGPDPPDU\H[FUHWLRQRIELVIHQRO $LQ6SUDJXH'DZOH\UDWV-7R[LFRO(QYLURQ+HDOWK $ 2WU]\PDQR =DDNFHSWRZDQRGRGUXNX

Cytaty

Powiązane dokumenty

В статията разглеждам днешното функциониране на родовата памет не като определено количество информация, придобита от разкази и изследване

Stosunek ciężaru śledziony do ciężaru ciała był niższy u myszy karmionych paszą zawierającą saponiny w porównaniu do myszy grupy kontrolnej. Jest to wywołane

Zasadniczo zatem status dorobku przekładow ego dobrego i dośw iadczone­ go tłum acza literatury pięknej czy naukowej różni się od statusu dorobku leksykografa tym,

Książkę uzupełniają: tablice synchronizujące dzieje życia zakonnego z wydarzeniami historii powszechnej, mapa prezentująca główne ośrodki życia zakonnego w średniowieczu,

 skrobia kukurydziana poddana reakcji utlenienia wykazuje większą ilośd grup aldehydowych niż skrobie dialdehydowe, otrzymane ze skrobi ziemniaczanej,.  po

Recenzja pracy doktorskiej mgr Katarzyny Mokrej na temat „Ocena wpływu bisfenolu A i jego wybranych analogów na jednojądrzaste komórki krwi obwodowej człowieka”.. Każdego

The results point out to two reasons for the differential output trajectory in Poland as compared to other CEECs: (i) lower exposure to foreign shocks being the result of a

During the field trip the issues of fluvial landform and alluvial deposits of the rivers were discussed: Sabarmathi River, Mahi River, Narmada River and Karjan