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A Review of Studies About the Genes Encoding the Collagen Proteins in the Context of the Anterior Cruciate Ligament Rupture

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Academic year: 2021

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(1)

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THE COLLAGEN PROTEINS IN THE CONTEXT OF THE ANTERIOR CRUCIATE

LIGAMENT RUPTURE

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Address for correspondence:

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Abstract.

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Key words:

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Introduction

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(2)

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Collagen I (COL1A1)

Collagen I DFFRXQWV IRU  RI DOO FROODJHQV &ROODJHQ , is a KHWHURWULPHU FRQVLVWLQJ RI WZR Į DQG RQH ĮFKDLQV7KHĮFKDLQLVHQFRGHGIRUE\WKH&2/$JHQH&2/$FRQVLVWVRIH[RQVDQGLVORFDWHGRQ FKURPRVRPH T =KDQJ HW DO  &2/$ contains a IXQFWLRQDO 6S ELQGLQJ VLWH SRO\PRUSKLVP VLQJOH QXFOHRWLGHSRO\PRUSKLVPUV ZLWKLQLWVILUVWLQWURQ 0DQQHWDO 7KLVSRO\PRUSKLVPKDVUHFHQWO\EHHQ DVVRFLDWHGZLWKFUXFLDWHOLJDPHQW &/ UXSWXUHVVKRXOGHUGLVORFDWLRQ 6' DQWHULRUFUXFLDWHOLJDPHQW $&/ UXSWXUHV DQG$FKLOOHVWHQGRQUXSWXUHVLQWZRSRSXODWLRQV .KRVFKQDXHWDO3RVWKXPXVHWDO 0RUHRYHU SUHYLRXVVWXGLHVVXJJHVWHGWKDWWKHG\VIXQFWLRQRIW\SH, collagen genes was associated with disorders such as RVWHRJHQHVLVLPSHUIHFWDV\VWHPLFGLVHDVHVZLWKVFOHUDOWKLQQLQJDQGP\RSLD <DQJHWDO0DULMDQRYLüHWDO 0F%ULHQHWDO 7KH*WR7VXEVWLWXWLRQLQDQLQWURQLF6SELQGLQJVLWH UV UHVXOWLQJLQLQFUHDVHG DIILQLW\ IRU WKH WUDQVFULSWLRQ IDFWRU 6S DQG LQFUHDVHG JHQH H[SUHVVLRQ KDV EHHQ RQH RI WKH PRVW H[WHQVLYHO\ LQYHVWLJDWHGSRO\PRUSKLVPVZLWKLQWKLVJHQH 0H\HUHWDO 6WXGLHVUHYHDOHGWKDWWKHUDUH77JHQRW\SHZDV VKRZQWREHXQGHUUHSUHVHQWHGLQVXEMHFWVZLWKDFXWHVRIWWLVVXHUXSWXUHV .KRVFKQDXHWDO  ,QWKHLUVWXGLHV.KRVFKQDXHWDO  LGHQWLILHGRQHVXEMHFWHDFKZLWKD 77JHQRW\SHIURP   VXEMHFWVZLWK&/UXSWXUHVDQG  VXEMHFWVZLWK6'6LPLODUUHVHDUFKFRQGXFWHGRQWKHSRSXODWLRQRI6RXWK $IULFDVKRZHGWKDWWKHUDUH77JHQRW\SHZDVVLJQLILFDQWO\XQGHUUHSUHVHQWHGLQWKH$&/UXSWXUHJURXS RXWRI  FRPSDUHGZLWKWKHFRQWUROV RXWRI ,QDGGLWLRQUDUH77JHQRW\SHZDVDEVHQWLQVXEMHFWVZLWK $&/UXSWXUHV 3RVWKXPXVHWDO 7ZRVXEMHFWV  ZLWKD 77JHQRW\SHZHUHLGHQWLILHGLQD FRKRUWRI VXEMHFWVZLWKFKURQLF$FKLOOHVWHQGLQRSDWK\ 3RVWKXPXVHWDO 7KLVVHTXHQFHYDULDQWVHHPVWREHWKHILUVW VSHFLILFJHQHWLFHOHPHQWWREHLQFOXGHGLQPXOWLIDFWRULDOPRGHOVGHYHORSHGWRXQGHUVWDQGWKHHWLRORJ\DQGULVN IDFWRUVIRU$&/UXSWXUH 3RVWKXPXVHWDO /DUJHFRPELQHGVWXG\LQFOXGLQJWZRSRSXODWLRQV 6ZHGLVKDQG 6RXWK$IULFDQ FRQILUPWKDWWKH77JHQRW\SHRIWKH&2/$6SELQGLQJVLWHSRO\PRUSKLVPLVXQGHUUHSUHVHQWHG LQDFXWHVRIWWLVVXHUXSWXUHVLQSDUWLFXODURIWKH&/7KHFOLQLFDOUHOHYDQFHRIWKLVILQGLQJLVWKDWWKH&2/$77 JHQRW\SHSURWHFWVIURPDQDFXWHVRIWWLVVXHUXSWXUHDQGVKRXOGEHLQFOXGHGLQIXWXUHULVNPRGHOVIRUDFXWHVRIWWLVVXH UXSWXUHV &ROOLQVHWDO  $&/UXSWXUHLVD SDUWLFXODUO\XQIRUWXQDWHLQMXU\IRUDWKOHWHV,WKDVEHHQGHVFULEHGDVRQHRIWKHPRVWVHYHUH injuries sustained in a VSRUWLQJSRSXODWLRQ %URRNVHWDO 5HJXODUSDUWLFLSDWLRQLQRUJDQL]HGVSRUWVPD\SODFH DQLQGLYLGXDODWXSWRWLPHVJUHDWHUULVNRI$&/UXSWXUH 3DUNNDULHWDO 6SRUWVZKHUHVXGGHQGHFHOHUDWLRQ RUFKDQJHLQGLUHFWLRQLVQHFHVVDU\ULVNRI$&/UXSWXUHLVKLJKHU 0DUVKDOOHWDO 6NLHUVDUHRQHRIWKHJURXSV RIDWKOHWHVZLWKWKHKLJKHVWIUHTXHQF\RI$&/UXSWXUH +DEHOWHWDO $&/LQMXULHVUHSUHVHQWRIDOOVNL LQMXULHV .LPHWDO 

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(3)

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Collagen V (COL5A1)

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(4)

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(5)

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Conclusions

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References

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