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ginekologia
Rola niedoboru witaminy D w patofizjologii zaburzeń występujących w zespole
policystycznych jajników
The role of vitamin D deficiency in the etiology of polycystic ovary syndrome disorders
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Klinika Patologii Ciąży, I Katedra Ginekologii i Położnictwa UM w Łodzi
Streszczenie
Niedobór witaminy D, związany z niedostatecznym jej wytwarzaniem w skórze oraz ograniczonym dostarczaniem w pożywieniu, zaburza funkcje wszystkich układów organizmu oraz zwiększa ryzyko wystąpienia chorób przewle- kłych. Badania sugerują związek niedoboru witaminy D3 z objawami zespołu policystycznych jajników (PCOS) - insulinoopornością, hirsutyzmem, niepłodnością związaną zarówno z zaburzeniami owulacji jak i nieprawidłową receptywnością endometrium. Stwierdzono korzystny wpływ suplementacji witaminą D na poprawę insulinowrażli- wości, dojrzewanie pęcherzyków jajnikowych, występowanie owulacji oraz regulację cykli miesiączkowych. Z uwagi na ograniczoną liczbę doniesień, potwierdzenie skuteczności leczenia witaminą D zaburzeń w PCOS oraz ustalenie jej właściwej dawki wymaga przeprowadzenia badań randomizowanych. Wydaje się jednak, że wdrażanie właści- wej suplementacji, szczególnie u kobiet, u których potwierdzony zostanie niedobór witaminy D jest postępowaniem korzystnym dla efektu leczenia pacjentek z PCOS.
Słowa kluczowe: witamina D / ]HVSyá SROiF\Vt\F]n\FK MaMniNyw / inVXOinRRSRUnRĞü /
/ niHSáRGnRĞü /
Abstract
Vitamin D deficiency, connected with insufficient production in the skin and limited alimentation delivery, disrupts the function of all systems of the body and increases the risk of chronic diseases. Many studies have reported associations between low serum 25-hydroxyvitamin D [25(OH)D] level and symptoms of the polycystic ovary syndrome (PCOS) – insulin resistance, hirsutism, and infertility associated with both, ovulatory disorders and abnormal endometrial receptivity. .
Otrzymano: 15.11.2012
Zaakceptowano do druku: 15.05.2013 Adres do korespondencji:
Maria Brzozowska
Klinika Patologii Ciąży, I Katedra Ginekologii i Położnictwa UM w Łodzi 94-029 Łódź, ul. Wileńska 37 tel: 42 680-47-25 fax: 42 686-04-71 e-mail: koala.mb@gazeta.pl
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The beneficial effects of vitamin D supplementation on insulin resistance, ovarian follicles maturation, ovulation and menstrual regularity were confirmed. Due to limited evidence, the additional randomized trials are required to establish the correct dose of vitamin D and confirm the effectiveness of vitamin D treatment in PCOS disorders.
However, it seems evident that correct supplementation of vitamin D is beneficial in the management of women with PCOS and low 25(OH)D serum levels, and that it could be helpful in improving the effects of PCOS treatment.
Key words: vitamin D / polycystic ovary syndrome / insXlin resistance / infertility /
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K O M U N I K A T
