• Nie Znaleziono Wyników

Kliniczne znaczenie ekspresji antygenu CD154 i receptora CXCR6 na limfocytach T w popłuczynach oskrzelowo-pęcherzykowych i krwi obwodowej u chorych na sarkoidozę

N/A
N/A
Protected

Academic year: 2022

Share "Kliniczne znaczenie ekspresji antygenu CD154 i receptora CXCR6 na limfocytach T w popłuczynach oskrzelowo-pęcherzykowych i krwi obwodowej u chorych na sarkoidozę"

Copied!
115
0
0

Pełen tekst

(1)1234567282 82

(2) 62.  ! "#$%#&!'() *+,-./ % $'0%!+1+23!450('!67 89:;:<=>?@AB>C9;DEF?GH;8;I:J>CGF?@E;8@>C9 K9EF8K9;L8;M;8GN9=9>C;F@>C9AB9DBFE;KM;?JO. P57Q62R2 S2 T85QU V W5X8562 S2YX Z W[ 7S[

(3)  \%040'0% \%05]^%6!_]4 ^]`BA9aBFGE9b<;cKdDEK efghfijklmnlmlm oW2VTXU pSUR 6T[8 8 1 W[ 7S[  oW2VTX qrss.

(4) .            . .             . 3456589 5

(5) 5 955 4556  !"#$%"&&'())*+(,'. -./010234561578953:;18<=.;>09<?@?;.0809A3BCDCE FG@HGIJKDLM?ECFNKJCD O?IPQMHLNPRDCNCSCTKKKUSPMTCSCTKKV W0X516Y3<3Z0./01[3\<8];:0X;^;_<<` Z0./01[3a560:<<3b;9<X;6;>095]3<3\0620.;_595XY.<c. 0.

(6) 0.

(7) 2345789 4

(8) 495 587 573   !"#$%&'%("    )*&'+,&%-%.&"  

(9)

(10)

(11) /01

(12) 2&13%#04(50  6

(13)

(14)

(15) 7,&"50

(16) 8

(17) 9"'"5&:

(18) 2&13%*"3%-%.&4(50,  ;

(19)

(20)

(21) <(055&$

(22) 1"#$%&'"-50=  >

(23)

(24)

(25) /%(*%(5"5&+=  ?

(26)

(27)

(28) @9#"(

(29) $-&5&4(50=  A

(30)

(31)

(32) @9#"(

(33) #"'&%-%.&4(50B CDEF4 G 4G93HI JK  L

(34)

(35)

(36) /%$%8"5&+JK   M

(37)

(38)

(39) N+4(+5&+JK  O#%542%P&9+#%1$%*&"

(40) Q

(41) *%'13"80

(42) 3+%#+304(5+

(43) &

(44) #01

(45) 2&13%#04(50JJ 6 R7GS97843893HGT

(46) *%'13"80

(47) 3+%#+304(5+

(48) &

(49) #01

(50) 2&13%#04(50JU ; V%'13"80

(51) &,,:5%-%.&4(5+J0 ;

(52)

(53)

(54) N&,P%4030

(55) W

(56) <X;

(57) &

(58) <XYJ0 ;

(59)

(60)

(61) <2+,%$&50

(62) &

(63) #+4+*3%#0

(64) 42+,%$&5%8+JZ ;6

(65)

(66)

(67) <2+,%3"$1["J\ ;;

(68)

(69)

(70) N&,P%4030

(71) W

(72) <X;>/]

(73) &

(74) <X;>/@J\ ^_`4SaG 7bbRcde4bRcfgJ ^hi7 j4SaG 7b4G57SIj J ;A <X YJ ;Y <X > J ;L <X >J ; M <X >;J 0 .

(75) 234355 67879

(76) 6 234352  23435 6 23  ! "#$ %$

(77) & #' ()  7! 9

(78) $8)*+ 43,-./01-234145/.673* 435 8$

(79) $& 7

(80) )% )&$ 9$'$ )88 "

(81) 9* 432 :;67-4<-4=7>1-24?4@-7-<1=*A 43 B06<CD6EF6G1-414G2=F-<1/46EF0>/H6?6GI887

(82) ()& J7 KLM*A 434 N0>3;6.6?-<1/45-./01-2=414-<-H1>-4C3.65/.03C><-*O 43  $!#($ % $ )% )8( $* 3P) #&#* 35 67879

(83) 6* 32 Q=@G6G=H-CR/4H15S6C3.T?4UVA 3235 #W 8) ) X 4 # YVA 3232 Z15S6C3.34U4U[\]^414U[\_`AV 323 #W 8) ) X 46 # 46aAO 3 [>bE./C>F-4F6E.35=H=RbC-4[cdeAf 34 ,-0F/034-F.3?-CR14H15S6C3.T?O0 3435 O0 3432 6O 343 2+ 3434 54V 3 N67E=56?-<1/4?3<1FT?O 3)%&%g$f h3P # %&#f Y3i

(84) 7%(8(7 #7f 0 .

(85) 234 567789  

(86)  35 

(87)  43 58 

(88)  443 !"#$"%%"&'( 

(89) )            . . 0.

(90) 2356789 8

(91) 8 

(92) 96 7  . !"#$%!"&'(()*+,"-.&).!"-/$!0$"*+).$"12$ 3/*)4)#!)#*"#0!,"(5'6$!")&6*-!#).)7(84!*-26).! 9:;<=>?@ABCDEFD%!*!+$+$),"6)G(#!6&"*H1$).$I")- -!$!"&+*'6+'*" ().$!*-4$).24"6)GH*!6I"05H.$!"#!'6)2+H. :9J()K!G)LM"2%'-2K"(5'"#"+#!6'".80# N:OPQRAB?ASFTSER>UC@T?CRV WNX2%)*!"!Y($*+)*2")#'G!"$"%$*&+"&!),"+81)")/K8+)LM".2!4)." UFABR?ZC?A[>SECRT W\O9;D=>CBA?<AFSF?C@]FT<VTST@A^BCEZT_ZST<ZSF[TD=>CBA?<AS<V_SA`C W9%)*.*"&++!*"4!#,"!+!!*"*)-(*)&-!$"L.$+5"-0)$!"-"6$!*'6$!G" .$a-6$"#&!*).!K bP`=F[C[CBV[C?@ABCFEV bcdefgh&6$"i$.!*&2+!+"j!2-2 \;FS@AB=A>[FS^FS@AB=A>[FST dk9GK)*"4$&))G(+$/$#$+2")G(#!Y,"05H.2"'65"-0))L$"+66).!K l9m;U]V<CABV@]BFS7<VTSFSnop^BCEZT_ZST<ZSF[TD=>CBA?<AS<V_SA`C lN;U]V<CABV@]BFS^BCEZT_ZST<ZSF[TD=>CBA?<AS<V_SA`C qlNr9sm;U]V<CABV@]BFS7<VTSFSAn^BCEZT_ZST<ZSF[TD=>CBA?<AS<V_SA`C qOb/$!"-K8$!,"*!+0!).&6$! 9&$!"&++!*"4!#,")+!6+)*"*)-(*)&-!$"L.$+5"()"6a+!G"tu"&+)($")")&$" CU@V<ZSA_ Ov;w<V@C@CxF<<A==?^=FyDC<V@Vw<V@C@C[?V<ZSA O9qz"!##"*!!(+)*,"*!!(+)*"#$G%)2+H."z O{;w]A=UAB<A==?^=FyDC<V@VwUCyC<SF<ZA OP|q+)G)0*%$"6)G('+!*).".2&)6$!K"*)--$!#-)L$ O3+*&/*)4$#"#'0"/$)(&2,"(*-!-)&6*-!#)."/$)(&K"(5' O9+)+#"#'0"($+2,"56).$+"()K!G)LM"(5' O}W;@>yCBSA<BC?F?DT<@CB^<ZVSSF[yTB@RF<VSCRC@RCB> X9$+#"($+2,"()K!G)LM"12$).     . 0.

(93) 2356789. . 23 

(94) 

(95)  23 3 

(96)  !"#$%!"#&'!!&"()*(#"!$+%,&,(-!(-./!*.0'1$2,(-3 +45(6!!7!89$(#!(-29&*:!!$(5"#!$)!&!4!;<!&!;<<3<<<!$./3=>?3 *2#(#!2#45@!.1&,(-!&,(-3AB33CDEF3BA3FG3>?3HCC3<<<!$./I3JFKDFGLM3N4.2&#! 2,$%)+5"#!5!04,(-!$4,(-!0),!O<!!P<!#0!1,(M3Q3RS?>BT>?UVV3V3 W+&!/$#25"#!$)!5@!$(,%3(-2X!2*.!/#%!+!Y<!5!1,(! JZ[DFKLM3 3 3 23 32\]^_^` ]ab] cVdeUfgdhA3AiVfj3f?eSAV,!&4!W6!k5%(-&$&!2!;lmm!5!n0&,! $.&#!+!+$%('!50#&!@52%#@o6!7!;p;Y!5!q6!r5&%,!!s6!t%%u! +2'9!2,$%)+2&#!0&!$.&,(-!2!$#!!2(&,0!2!vwN!9%! +#$2#"!+2)$#&#0!2)4.2!(-4&&,(-!2&)!!&(#0!2!+45((-6!.%! ttx!51,2&,!&!#*9#&#!$,x!2,2!$)!!&2$!/(,!y6! t#$&#x!z6!t#(!!W6(-50&&x!%.,!+$,29!.1&'!99(")! 0&! $9&,(-6!{2!|$}x!$%$2&!2!;lpp!5!+#!z6!t#(x! 04!2,:!+/#X$%23~VfAi?A€AhVg>d3!|0)$!‚3$(0}! JZ[DFKDƒHDHCGLM3 3 3 23 3„ 

(97) b]†‡

(98) 

(99) bˆ_^`

(100) `ab] 8(#$!(-/2,!/#"05"#!*.0'1$!+45(x!%"6!+#$%#X30),!/4&'! +$%2&'!+)(-#,.2!+45(&,(-x!!*./4&#0!&(,X!24$AU?T-6!7!5")(5! S€V>Vg>T‰3 g?3 |*.0'1fg}! +,"05"#! $)! 2%*:! +#@.! 0),+)(-#,2,(-!!*2%4!+)(-#,.23+45(&,(-x!"!.2&#1!$#:!&(,X! 24$2%,(-!!90u%,(&,(-!!%&)34'(&'!4&(,&2'!!4$#92'! J[FLM3Q3Š?B?>Vj3~VfAi?A€@(&,0!$%2#!$)!&&!$9&#x!%.#!23 #(,2&#"!2)$*(!+,+.2!&#!59#@"'!$#2(#&5!n0%2(,o6! ‹%2&#!$'!!0.#!&/4&2%,(-!!2#9"'$%,(-!0.#!9/,0(-6! r0.!%#!+2$%"'!&!#!+#$%4(#&!0&(,%.2!2!0u@x!! >?$%)+&#!(-!u5"6!7!$43&&.232(-'!.2&#1!€V‰ŒATTD3g€AS?€VgAU?>d3 @4.2&#!2!()*(!/22#"!JZDFKDFGLM3 0 .

(101) 23435789.

(102)  

(103)   9 !"#!$% $"#!%&#'()'*+,-.+)-*+/0/(1 /(+12./(+34&"56&7#898$#%:75;9"%$ $%$<#!"79&!=9!86# $<9$!$9>#&=?@=6!6!:?$%#&$:$"#!47>!?#$>9#6&!#!9!86# & :!5;$%89!A:#B%?C9$:B9!%7$&76#>!!476&76D@84E9!"$F6&!#?& 6&7#8=#A9$%$"#8$"7=#=$>=$%7G#8$"H9&'I'J/0--I+KLL3LM3NOPQR$6& #B%78?!4!=4?%&#F?948>9?S:#67"!4#$ 4$>!!&#!98$#%$&7KLL3NOPQ TQUVI'./(.1(VW'?%&#F<#F!8&$8?4!9=#6&!>$X76$<64!9#?= *VI'/VY-11Z[*I\012]KLM3O^PQ_)'T``abZT`1'`-*-Ya*-Y-YJ/b*V)+-, b/-)-11]14"#!9%&=$C:#"$AH?%&#F?9EC76D6&7#8E"A9$%$"#8$"+/0Q c-*.')($$9E"#!C!>47"7&"#&!898$#%$&7&:!#!=474$#?KLL3NdPQ  2343ef8g8  h i$&$&#!98$#%$&7$ #!9#BI)V01*-2*-Y-J/(+j3. 84E97=4"#!9%&#B$<!6$AH#!!9$"6#!676D&#9##8E"98$#%:76D" &B476D9&%6D5k$#!6&!W'1*"EF"74B $"#!47$"!>$%:98$#%$&7 -I(VY/('J-)-Y-J/(!>$5l78:?6&!#"7=>'/0--I+ (-.'-2-)-I+j2('I'JVKLM3NO3Nm3nNPQ  2343opq8

(104)  r8 9 s&6?!#B@C!?$8$F$tuv6D$976D98$#%$&B"7897"#B9&7%8$"$@ 45"4986#!9?47$"76D<%w$89!$"76DZI)')-Y-J/('Y*2'1-.'W]Q R7:8$xuv6!4E"9!&!4?!$<"7$>E:'Z$F<#!#!@>$96&8@?494=7 6#F]Qs98$#%$&=$C!%$476&7H8C%!>$9&%?5y<9&8:##6&7&:!C7$% %$=#?6!:$8:#&6##9$&:!>F$A6#&=#@48C!847"$A6# 9$6!? 6D$9$<$"!>$5z6&BA6#!&B4! F?6{|}uv~#"B&F76DF$!"B8# A9E% #!9#{}\Mn€]Q=#7$F?6D$"!@>FE"#! $% $46#49&!&6&!w% $:=#F?67=#34"#!9%&!?=#!#C‚uv6D$976D5ƒ$8$F$‚u€\xuv$E< 1+<#F!"74B ?!$497$6&4!898$#%$&7@4&"5&!EF„ G>9!Qc('I'J- &>$96&8@$<?49$7= $"#B8&!#!="B&FE"6DF$76D"B8 F?676D@ 9?=#!#!=>?&$"47=#<E:!=4"E"5ƒ4B ?!&"78:!=$#4#!@"9$47 6D$9$<79&%8#!5s98$#%$& 9&!":!8F"74B ?!?$85†u€\O^€/0-+/0 ‡tx@tˆ@‰tŠ598$#%$&B 9&!":!8F?&"!W'1*V*(+j+.'1#B&=# 98$#%:76D$"7C!‚Y*KNO3MnŠ@#!84E9&74$?9E"#!C+*'Vj‹Y*KŒ3‹LPQ  . 0.

(105) 23435789 9

(106)      !"# $% &' &!%!%" ()&$ *+,-./*/0123453401034.064*7*84951234:06*+.23,;01<(%=>?(!"<? @AB:AC:DAEFG0H*6,;0/4-I70,2951-8*+060140.064*7*84951-8*I70;I4H4-.,4*/-J /2='?))K&)=L%)&%$MN<>OPQ   R0+-70SFT;0640,0.I*46*52UVRWX+06014-.064*7*84951-YF Z[

(107) \] ^ 9_

(108)   `] a

(109)  ba8

(110)  \cde_ [_ f b9^ abg N$!)&i% h % M!%$!i?>%L>)$"L%)&%$P %$<$<?)<?L!i?jk"Q!%)L$%?<$i S ! ji%??<?L!i?j)l>Nm=&!)<) $$#<!%)L$%?($i%(ji%??( n 6%. *+1*8o5I*/-534012%$)?<()#'$!i >L%$()?%$)?<m=&()#'$%< B MN<$%$$#j!%)L$%?j$i= ji%??jP C $?%?<$()?i=L?)<!i   p$%I*14-951-J-,;/2I*1014-+060140;*3*8.0q44I*3Ho;-.*/-J/2,*I4-J %$&$)<>$%m)MrstuPQv)<&$)w?)((%'?(Q)?QjL<$?%$Li& 534016.*+1*8o5I*/29x:;JF%L%i%%L$<>%%k%L%i%?$?)%%k!%&%!i?%%k /$&i' $$<>)? ()&$!i%jk "L =?)<' $N)<?)< !$<=& ()&$$$)L%jQy)<L)<&)&%$?<#$()?!z(7-951-J,5N{kL=< (%#m)&$w%!<i?)<?)!j<$L=!i?j!$<$?)<L)L%(=L%<) L$w?L?%mwj%%NkN#&|$)#$?<#$i=L?)<?)<(!iQ}%? J-,;*9-1010,47-?)$()?i=L?)j$<$>&?$N$%?#j)<L ()#'$!i?<%k%$$#<%$$<?)%L$<>))$()?!z!>()%&{Q ~%mwjL<$?<%N$&)%>%)$?<#?)<$L><!%(%?< ='?)%?)5/4-7*30411234m=&()#'$%34j%%N()!i@AB:AC:DAEF   0 .

(111) 3454689 9

(112) 9  

(113)   !"#$$%&!'%(#!)*+,-!*./('012"'3*4%5$6*$616./6789:;<:9 (0$/#=6!7'>*?,@($'0*+%2*+%./6!'8*"4'6$*10./1#A!#7$#!)B*C4$'07."6*.'D*"2%=$%&3* EF;:EG$6*2=6*/=0$A-*(D?=6*HIJKLMNOPQRSQRTQURQPRVW    3454XYZ[Z\]^_` abcbd9;!)%1#!)*"*"0.+%,04*Jef?10$6*70./b<9Wg<cbb: +1"0(=0A,646*!"D./%*+%2./D+$#*+%!"8/0A*'*1"62A%*-=0?6*.64%'./$07*104'.7'B +1"#+62A->*?2#*!)%1%h6*+%./D+-70*A%$'0!"$0*4%50*h#3*(,8!"0$'0*=0!"0$'6B*i02$6A* 6(1%/#*+%*=0!"0$'-*.8*!"D./0>*6*1%A%(6$'0*$'0+0($0B*j4'01/0=$%&3*(*.61A%'2%"'0>* ."6!%(6$6*$6*4$'07*$'5*kl>*"('8"6$6*70./*"*+%./D+-78!8*$'0(#2%=$%&!'8* %220!)%(8>"67D!'04*.01!6Q82m*%&1%2A%(0?%*-A,62-*$01(%(0?%*NRSQRTQURVW    34545no`pq`^_` r9:9;s<cbb:E$67!"D&!'07*./%.-70*.'D*?='A%A%1/#A%./01%'2#tuvgw NRQSPQRSQRTQURQPxVWsc:yb1%"+%!"D!'6*z9<{.8*"67D!'0*.01!6>* %&1%2A%(0?%*-A,62-*$01(%(0?%>*$61"82-*("1%A-*=-h*)'+01A6=!04'6Ws<cbb:9 -A,62-*%220!)%(0?%*=0!"0$'0*(,8!"6*.'D*(*4%40$!'0*./('012"0$'6*+1%?10.7'* !)%1%h#B*|/82*A%$'0!"$%&3*%h.01(6!7'*'*4%$'/%1%(6$'b<EB*L!0$'6*.'D +1%?10.7D(*"6A10.'0*h626}*!"#$$%&!'%(#!)<brb~:E+,-!>*$6.'=0$'0 %h76(@(*A='$'!"$#!)B**9:99rz9<zEd9{br9~:szbsbd;y9zbz<9csz;Q 6"6/'%+1#$#>*h82m*!#A=%f%.f64'2-B*I%/#!)!"6.*$'0*46G9cG9b::E  6}*&('62!"8!#!)*%*+1"0(62"0*/6A'0?%*=0!"0$'6NRQRSQRTQURVB*Lh0!$'0*h626*.'D* .A-/0!"$%&3'$)'h'/%1@(*€‚ƒt9z9<9{zQFr„yQ~bry;ywQzrby;Q +1"0!'(!'6,*4%$%A=%$6=$#!)*+1"0!'(A%* J†‡Oˆ†OSt;sz9c;ywN‰QSUQx‰VW {<:E{c;$'0(#2%=$%&!'*b9bd9G'*$62!'&$'0$'6*+,-!$0?%*d{<:99~; :dsbd9Gs<cbb:E<%"(656*.'D*(#A%$6$'0*+1"0."!"0+'0$'6+,-! NOPQRSQRTQURVW     01 .

(114) 23256789 7

(115) 677

(116) 77698

(117) 6

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`Vab[cdefgVab[cd4#!6,%#%"K'5-!6,%"/.-7%#%!/$*5#'%!+6!,-+%#% _^hVbf]Vi^jklmgnopq r$*--&#'%XY%,-!.&'%#K%"%(#'%"$,'&%,%&'*-+%5%!5'4#%"/$($% 8*!,'0%4.)%"%(#d4','&7%,%*",#$*$&I-+%#+%!5'4$%&K5-5!$%L<F7MNO1% T#'!#'*-%,-!.&'%#K%,%#-+%+#'&.%5'%,504K*.%$%$&,#K!5'%$#4'#'%"'.% 86*+#I35,'07%.,#*5#'0%,%)$*$#.%rDBs%!4$(!#%"#'#,'&%L<>?O1%t$%(% &'*$!%,#K!5'%5$5'#'%"5-%,-)5'%+#'&$%*%rY%E"5'5!5'4,'&%)#"&#% "/.$H%L?u7=u7=FO1%%:%5$!4#,$#.%!v6ibf\[V]_`Vwf\d[VabVxyizdZ]^jc !5'4#%"*'0+'($4-7%"*$&'%#K%,%"&$%64%R#5&40#5I%E>7={%T$@4H7%$% $(K"#'%*-$1%:#', 5$%*' $$%R$!&$%($,#%+$('#$/%5%,#K!5-%!5'4#7% !4'&'%(%"/-7%!(6-%*($/%*%*)-%!5'4#!6,%#%"K'5-!6,%"/.-1% Q(#'&I%4#5'%, !$5$#$%*%)R#)'!"##1%t3$%&'%"*5#'4#9%$% !4##5'7%$*#40#5'%#%5,#I5$'%5%4'5'#'+1%B%*#$0(-'%$5% 5'5'% c|ahVaVi|]fd c]|zZyzd \[V]_`Vwf\d[VabVxf| weyV[da_d]_^z]| f \fVxaz| x[cdcVab[cdeVi|x*%!(4I%.4($0$R##1%T$4'3-%"$+#K($9%%#(#'&I-% ,504K*-%"5'#,, !$5$#$%#%','(.$4-%",#!/$#$%5,#I5$-%5%$+-+% 5$)#'0#'+%4.)% (,$-+%5#'5.4'#'+%+#'&,-+7%5-%"'+'*-!$&I1% J"#-,$$%8+#'('489%5,#I5$$%5%)R#)'!"#I%,-#%>7><{W}g}~ klmgnogmnpq  00 .

(119) 345789

(120) 9  

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`aabcN d0()1-(2.324-350*)*0.'<5&:&.',@.4.A<5&:A.;0:2&A7,/4+-\)O.)3(0/4+-\)O.:-(-<()2=*. ,.<)13A(-2&>.e&1,+&2+0.324-350*.9&:&+0/;.<)1=2-<.4)'(&6-.*01A'4)+0.324-4.. <)+'(2A</6@.A<5&:A.;0:2&A7,/4+-\)O.*0<)240'(A6B/-\).46&*,'<).;0:2):0+&1,/4+01. )\+,'<)*&+,-1>.f&:&+-.<)1=2<,.350+B.*B'<,1.'(2A1,-+,-1O.6-:+&.4&.:2A\B.*. )()/4-+,A.'409<).350+B/-6./,-/40.)\+,'<A6B/-6>.g(B:.1)87,*-.6-'(.90.+&.<&8:B. <)1=2<@.4.)')9+&.3&:5).C*,&(5).7&'-2&>.h2=:5-1.C*,&(5&.*./0()1-(24-. i24-350*)*01.6-'(.+&6/4@C/,-6.7&'-2.&2\)+)*0O.-1,(A6B/0.[&7@.).:5A\)C/,.Rjj+1>. k9-/+,-.*0<)240'(A6-.',@.:*&.7A9.(240.7&'-20>.l-:+)/4&')*).:)<)+A6-.',@.&+&7,4&. )3(0/4+&.,.*49A:4-+,-.[7A)2-'/-+/6,>.m-(-<()2.2-6-'(2A6B/0.C*,&(5).2)432)'4)+-.:). i_EZnopN]^cNEYZn+,-.4.<,-2A+<,-1.*,B4<,.7&'-2)*-6O.:)'(&2/4&.,+[)21&/6,.).*,-7<)C/,. <)1=2<,>.k:3)*,&:&.().3&2&1-(2)*,.qgd.r&+\>.q)2*&2:.g/&((-2s>.m2A\,.:-(-<()2. 2-6-'(2A6-.2)432)'4-+,-.C*,&(5&.3):.<B(-1.Vt.'()3+,>.u&2&1-(2.+&40*&.',@.ggd. vKLYcNwInMNwxK]]M_yNINZiIGo^MNJMJL@(24+B.'(2A<(A2@.<)1=2<,O.1>,+>.6-6.4,&2+,'()Cz>. T49A:4)+-.C*,&(5).[7A)2-'/-+/6,.3).324-6C/,A.):3)*,-:+,/;.[,7(2=*.6-'(.1,-24)+-.4&. 3)1)/B.):2@9+-\).'0'(-1A.:-(-</6,.QRORRORVS>Nq7A)2-'/-+/6&.4&7-8+&.6-'(.):. A80(0/;.:).9&:&+,&.324-/,*/,&5.1)+)<7)+&7+0O.<(=2-.'B.'324@8)+-.4.):3)*,-:+,1,. 9&2*+,<&1,.[7A)2-'/-+/06+01,>.u24-/,*/,&5&.(-.5B/4B.',@.4.<)137-1-+(&2+01,. &+(0\-+&1,.3)*,-24/;+,)*01,.+&.9&:&+0/;.<)1=2<&/;>.{'()(+0.6-'(.*5&C/,*0.:)9=2. 9&2*+,<=*.[7A)2-'/-+/06+0/;O.*.'3)'=9.A1)87,*,&6B/0.A+,<+,@/,-.+&<5&:&+,&.',@. *,:1.-1,'06+0/;.9&2*+,<=*>.d4@'().3)1)/+&.6-'(.(4*>.<)13-+'&/6&O.<(=2&.3)7-\&. +&.-7-<(2)+,/4+01.324-(*)24-+,A.3)4,)1A.[7A)2-'/-+/6,>.{+(-+'0*+)Cz.[7A)2-'/-+/6,. 7,+,)*).<)2-7A6-.4.\@'()C/,B.&+(0\-+A.+&.3)*,-24/;+,.<)1=2<,>.|&6/4@C/,-6. JFHZ_EFG]FJKLMN}K_JLIHIN]ZN~€NvKLYcN‚ƒoZ_MGxMILNIGZ]„IZxFKLK]MNIEZ M_N†ypN‡ˆN vKLYcNi„FxZM_F]„_ILypN‡ˆ‰FŠNvKLYcNi„FxZM_F]„_IL‰xFKLILMNŠypN‡ŠNvKLYcN i„FxZM_F]„_IL‰/0&+,+.‹>Us>.P=8+)2):+)Cz.:)'(@3+0/;.324-/,*/,&5.,.9&2*+,<=*.1)8-. 01 .

(122) 3456378 7

(123) 6 37  36   3437

(124) 7  7  7 76 637 6 4

(125) 375 4 3 7  6 7

(126)  !"#""#"$%& '()(*(+,-./01-&3 6

(127)  4

(128) 456336&

(129) 7 7  7    *21-1&3()(45&4/&,6*7.8&-.-9)250145:&;8)/)-014,-&</4-&+&*(8)/0,&0532(+-=& 7

(130)    3 4 

(131)  >

(132) ?7

(133) 37 7 36 @3  7 68 36 @3  36736 A 7@3B# 36 @3 3 36736 A67@3B  ? @36736 C7

(134) D  37 6   36 436 A 4B# 7 @6 7 4 3 7 36  4377  7 ?77 7 @7 E637  @3  36 @3  D A?

(135) 76   73 D @ 4 77  6

(136)    63 D8 ?7

(137) B  ? 36 @3   36# 

(138)  D8 @ 367 7   4

(139) 7 F

(140) 6 6 

(141) 3 ?7  7 

(142) 8 36?7  32/G6-4)5&(H2/17&4/&-92/4,-&9(4 7#  36?78   &44 7 @  6  478 7

(143)  7 7

(144)  !""%& I J  64 @36K 

(145) 7

(146) 7

(147)  73 7 6 @3 776

(148) 6 7  @ L7    

(149) 7

(150)   3 3 4@5

(151)   <,/G4(8)50-&M-6/)(.(G,014-=&*215&2(1*(14/+/4,7&+,-.7&=-<4(8)-9&0M(2(H(+50M:&N& O$PQ  3437

(152)    6 6  7

(153) 3 37 4

(154) 

(155) @ 6 7 6 @3. 7 43

(156)   @ 

(157) 3 RS&T/4G:&R.78)-2&S,33-2-4)/),(4U&,&0RS&T/4G:& R5)(*./86,0&R.78)-2&S,33-2-4)/),(4U&&7 7 6 @3 647

(158) 76

(159) 6 !VW%& & & XYZ[\]^_`abc[deefg]h]idjkgl[ [ XYZYm[[[ndeo]jc`c[p[qrZ[d[qrs[ t,63(056 I 6D 

(160)  &4/&.,63(05)5&u&*(6(04,01-&TuMU&,&.,63(05)5&u& 05)()(985014-&Tu0U#  75 43778 6&u&RSvw&TuMU&,&.,63(05)(6&u& RSxw&Tu0U:&&;?  37#  RSv&,&RSx&4,-&<-)-26,47=-&37490=,&*(6(04,01-=& 015&05)()(985014-=y&/&=-<54,-&7637 

(161) 414/+/4,-&/4)6 @3 3 45

(162)   1& 

(163)  

(164) 7 43  Lz{ 7 6 ||  ? 7 6 |&}~€     6@3 RSvw&<(&RSxw&+-&92+,&.7<1,&1<2(+50M&+54(8,&(9:&‚y~&T(<&ƒy„&<(&yƒU&}~€:& {

(165)  

(166)  Lz{ 7 6 || 4

(167)    7 6 6

(168) 3 

(169) @3 A 4

(170) 7637 6 ?7B# 7 

(171)  

(172)  Lz{ 7 6 | 5@3  7 6 6 6 

(173) 37  33 

(174) @3# 8 4,-9,-<5y& 7 

(175)  4

(176)  7 

(177) 63y&@3  7 6 6

(178) 3 

(179) @3&}~€:& t,63(05)5&u0& 

(180) 

(181) &? @ 66 I 701-  

(182)  3 43

(183) & 64  7   @3 † 477 7637# 47  01 .

(184) 3456789 67

(185) 7984    6 3

(186) 393 7984 8 7  39 7   

(187) 56987 9!  6

(188)   3 68" 8976 34567 7# 798 "$% "& 7 "$' ()

(189) 3 96

(190) 9 9!7  6 798 "$ 7 "&   !996  *9 66 $+,- 39 .798 "$ !7   9986789 9!9 7

(191) !7  9439

(192) 9 /  5

(193) 67 7

(194) 3 967  7% 30 7 7 67

(195) 437 0 

(196) 37 7% 6 *890 

(197) 371% 798 "& 8

(198) 678 9!9 7

(199) !7  "93 6

(200) 9 /  5

(201) 67 67

(202) 437  95 7 6  7

(203) 7

(204) 8 7 0 

(205) 37 7 6 933

(206) 7 03!93

(207) 371 2397  3 68" 8976 95

(208) 

(209) 8 7 67

(210)  

(211) 56987 9!  68" 364  3 

(212) 5 9 34 67

(213) 5 9! 39!    5

(214) 67 % 943

(215)  3

(216) 

(217) 688" 6

(218) 6 7 8

(219) 8

(220)  988" 23 !93 

(221) 38 7# 09!48 798 " 3   93

(222) 96 

(223) 69 7 39!   3 68" 897656789:5 5 5 ;<=<;>>>?@ABCDEFG>E>HAIAJKCHG>I@ABCDEFCLA> M98"8  67

(224) 

(225) !6978969 

(226)   78

(227) 9 8976 *956 

(228) !7

(229) 7N  

(230) 56987 9! 0!9 % !7  67 % 8 #9 67  O7

(231) 7

(232) ! 

(233)  

(234) 8976  78 6

(235)  !9 34568" 3 P0

(236) 869N 3

(237) 8

(238) 93 ! 8976 6 ! 6

(239)  9438

(240) 36

(241) 957 9N 

(242)  9!!7  67 67QR78R8S9:55 T)UVWXYZY5[\SR[\]R5[\$' 97 !  3456

(243) 3

(244) 8

(245) 93 8"

(246) 9769

(247) 6  9

(248)  9 7

(249) 38"67% ! 78" 3456 9!9 7

(250) !4 6 09!48

(251) 8"

(252) 9769

(253) 5678R^QR_7R8SR8]9:55 `"

(254) 976  8976 7 9 !7  67 8"

(255) 9 86 7 3 !99!9067

(256)  8 3456

(257) 09 8

(258) 

(259) 984 % 87578" 397

(260) 3 8# 7 3456789 67

(261)  `

(262) 8" 7# 9!906 0!9  7 9!!7  67

(263)  6 a5bcUa5 3

(264) 8

(265) 93% 8"9N 8#9597 !   97

(266) 3

(267) 8

(268) 935678R^QR_7R8SR8]9:5daX\ce)fU5 3

(269) 8 9!9 7

(270) !4 

(271) 984 6 8"

(272) 976 9

(273)  76 6 3 87

(274) 3 57 987 gaXahZWg 6 ! 6 8"

(275) 976# 9 

(276)   !7  67 /!

(277) 

(278) 6 8 3

(279) 8

(280) 93 1% 89 957 7 3

(281) 86 73 8# 

(282) 984  `"

(283) 976% 8 !93

(284) 67

(285) 

(286) 984 % 9 9! 

(287) !698

(288) 67

(289) 3 # 78" 3 57 987 6  9

(290) !7  67

(291)  O7

(292) 43

(293) 73 /6 ijk1 93 3

(294) 8

(295) 93 8"

(296) 9769

(297) !9   5

(298) 67 943

(299)  99 67

(300) 3

(301) 8

(302) 934 8"

(303) 9769 8" 3 587 3

(304) 90769 6

(305)  8"

(306) 976 0 3

(307) 87 87  3

(308) 87 3

(309) 8

(310) 939 7 ! 90 957 9N 90396 3

(311) !   5

(312) 67

(313)  *990 34 67

(314) 5 7

(315) 67N59!9 7

(316) !4 

(317) 984. 397

(318) 67l5 73 87%  87% 397

(319) 3 87% 8 3456789 67 567QR78R^QR_7R8SR8]9:5 5 5 5 01 .

(320) 3454689

(321)   !"#$%&$'()*+,#-,$. $ $'()*+,!/-)/01234#5676'"*,7*''.+*'+' 89:;<=>?@4#A-)+!+/*')B').+* )B'CD")B''.)BE,/)*F+)6)!" $'()*+*$-6+*)G)')B$E)E)!/BCH"! ./*EI/*',$'()*+,.$'")B!+/+.) '-6.)!6I!"'"*','E,/.EI+#JK=;LMKM>;N# 012OP1OPQO2RO2S34#TB.+/6'-)"$'()*+, '!)G+,*'..!*+"/*!"#;<UV:M<M?#J;<:4#WV?LX8YVUMZ# B'-[C/-!+6$'()*+)B)6!+)).+' !$G+,/6.'!*'',)BE,/# 012OQ\OPQO2RO2S34## # # 34545]^ _

(322) `a ab8c5def^8c5deg $7E).+-+++*-'*,7!"$'()*+* ).'")Ch,76!"(''(!(+*+**JijQPNO# 6) /+*)$'()*+,Ck'()*+*lmDnohpq(' 7 '!)6!+)[!+6. $"$'()*+,#)*)BG+C+)BG+, !.+/*!)+*- Ck'()*+V#lmDnohrq(''/'! )6!+)[!6$'()*+'.'")G.(6)*'67.'"*+' <$'(+*)*'Cs+6+'t$V?LX8YVUMZ#$-B'-u$E$#L8v98U@# $'()*+,l.'")+./)G-..!*+"/*!"+*-' q.C!!+)6w6[Ck'()*+*l)676-/,.'"*6 6'$'(+*)*'#01234# x'"I'' $-).$.*E.!6(+*6 .w'' $-)6.)!.-+++*-'Cx!* +++*-'. !+$)*$'()*+,G+,.) ..+-6! +..+*q.yz&[CD"')B'' ;<UV;L8LU8UVY><V?#L!+6$'()*+*.'")G.*-+.+,*++ +*-'Ch,7B.+*+/')6+*'*!".'")'' $-)C r.6!"/7/-)E)$'()*+,.'")G)* !+ ZUV?@W;Y{=#;<UV:M<8vM{4#|<UV:M<#vV/6)*.+6.w'7.+I 'CC"','*+*)*'Ch,7!+*' $)*7 '7$!+. $'()*+,.'").+*-*#0S}O12OP1O2~O2S34# 01 .

(323) 3454689

(324)  !"#$%"&'()*+,-.,/012.3'&+,4"567"89 :8;<"6#867=8" >)3)?&.>@,&AB,CDE,FC,3)//,>)3)?&.>GH"4IJ"%9K8#L"567"%"K#M:N"OP::NM#"8" :%Q;::N"%!L:N""67OL:NH" "#"89#8K8# 5"8H"RSTUSV"W!X8:L7M#"4" Y86K":Y78L"7#8%8 "Y%%"OP::NL"Z""[\""7LW8"]T^V"Y%%"OP::NL""_"" `H"a!X8:L7L"4_`":N7L%5$"6Q"#Qb6%L!"%6!"8%Y8%#L:N" 7L= M#"""#L!=5$"Y%7:5"7L= "#"Y8O$:%"%":%$67:%!"cdIH" c8=$"8%Y8%#<"X86X87L= L"#L7#% "YH"Y%%"cL:89:7!" &+e)>3+/.f0f, ghiTiij, 9O" 6%8" :YW =8H" k O$" 8WQ" K%8" 011+*./.(03l*)(.,m.*0)3l*)(.,-/@,+&>l'1@*0@,n.1).f&@l',+f&>.A+,F?>.3)f', !!8!8KW:5G""678#$"YWQ"Y#87$"#"6786"K8"W!X8:L7M#"4Z[H" a!X8:L7L"4Z["8%Y8%5$"7L= L"Y Y7LK8# "#"Y8O$:%"%":%$67:%m@10,hgD, #"9O8"8!M"Y%75$:L:N"7L= H"6YMO:%67:%$"#"898"Y%:#8" !88=%!8!"K%Q"9 %Y8;K!" X78#":L78786L:% !\"9$Ko" Y8;K8"#6Y8!=5$:"8KY8#Ko"!!8W8=:%$,pqrjqsjstuB, 4IJ"O$:%L"6Q"#"9O8"W!X8:L7M#"4"%"8!YW6!"IvwH"xP::NL"Ivw" Y8;K:%$"#"Y%%L#"6L=O"7L#5$:=8"8!MQ"8K":Y78"K8" #Q7%"8!MH"a!X8:L7L"4"!8b"K 7LX8#<""Y8K67#"89 :8;:"Ivw, pqsuB, , , 3454yz{|}~€‚ƒ„ €}|†~‡

(325) ˆ ‰Š‹ Œ‹ E.l?.l*@*0),f.0f&)(.,@*&'()*+,?>l',?.1.3',4IJ"%Y8:%$78#5" 7L#:5Q"W!X8:L7M#"4H"Ž5"86# :5$"567"Y8WX:5""Mb:8#"W!X8:L7M#" 4"#"8!M" X788# ,pqrjqsuB,k%%L#"6L=O"K8"#Q7%"8!M" #L!="89 :8;:":%$67:%"!8KW5$:L:NH"v8"7L#:5"W!X8:L7M#"K%#:%L:N" 8:% "6$"K#"6L=OLH"k#6%L"Y8:N8K%"8K"7L= "8%Y.l*@*)(.,?>l)l, 4IJ""Y%% =8"K8"#Q7%"%"Y8;K:7# !"8!YW6"IvwH"v==8" 6L=O"K867:%5$":%$67:%"867L!W5$:H"Ž;W"9"567"K==8"6L=O\"78" /012.3'&',-l#:%"#:N8K%$"#"67" =\"75H"9"!8bW#8;:"8%Y8%" 7L= "#"Y%L6%O8;:"# 7"Y8"87%L!"8KY8#K5"m.f&'1+/@3A0,pj^uB, a!X8:L7L"4"Y8!8::%"":L78786L:% "#L!=5$"8KY8#K8"K%O":%$67:%" Iv"W9"Iv‘H"’79W "Y8O$:%"!QK%L"W!X8:L7!""8!M$"Y%75$:$" 7L= "!8bW# "567"K%Q"6LY6"!!8W8=:% 5H""55"7#8%" #6YMO:%67:%$":%$67:%"KN %L5 \"!HH"":Y78L"KW":N !8,p““jqsuB, , 01 .

(326) 34546893 

(327) !"#$%&'(& )*+,+-*.-..+/+,+-!01),-+2345667" -89,

(328) :;-<=43=>-89,

(329) ;!

(330) -1-+-))*

(331)  -!-!,-1-+)*-)?-@*)*++AB4CD"E$(" *9,-F,-1-+)*--.++-

(332) :=!

(333) G3:"H55DIJKL" " " 3454 89MN3

(334) G3 *9,-F!OP-++

(335)  -.++-+-

(336) =-

(337) Q!

(338) G3 ++-1+:=45664(%RS'TU" ,-1),-,+,!0*9F-'T&"RV"WXCY"EUZS"R'$"T'V&(R#$'$"'$" ),-*-+,-89,[!O*+,1*+9*-.+/ ++,+1-8"H55DIJKL" " " 3454\893N WXC]"EUZS"/+^?*)*++AB4 !01)"'$"$(S_#'_`a" bTcdR`_S$`a"e"T"f"HIJKL"g*h+-1.-++**+"#`iUZ'UE"$(S_#$`ET"H5jD56kKL" lTcdR`_SRc"e"WXkmbR#WXC]maTna")*)--1*1*.+*,).++ a$cR#$'T&"%Ri#RE&"bTcd9,+*+,-P,+-+-*- $(S_#'_`a"%U$(`ET"Tcc&'RbRnT`i'_`a"H55D5kD5jDIJDj6DjkKL" " " 3454Mo89MN5

(339) G3:p

(340) :=BqP-+/-+F*-[rs!B-.++ 'TUnR"EUZS"WXk6L"tib$("WXk64

(341) :=B++.+F,+,)*+,+- -89,[-u!0-F-1.#ZvRc$n$'TUc",/+h-,h- 9*)*+.!

(342) G3:,1)./9,-++, bTcdR`_S$`a"WXkm"H55DIJKL" " " 3454MMwxyxz{|}8~8w W€W‚"EUZS"%U`UvSR%Uc"`aUcR(T'R#_c"`a$%$(SU%_ZS_`i'_c"Vb$"RVvR#TUViT" ea54"T"ea5J4+F"Hk‚DkJKL"01)++,-8+[!ƒ+ E$(R"(R%U`UvSR%D"&cF-,-+++F-9*)*,-*„A "HCIDIJKL" 01 .

(343) 34546389 

(344) !"#$!##%&'' ('')*)#+,#(#,'-!%%,#,'./0123 45607+(#(,./01839:;<3=>?@:?:=3A>?BCD3EFC:;G:H3>@<IE>FHJ3KLM2NOPQ83 R R 34546STUVW9X YZ[0 \!((!]^%_#'`a#!bc

(345)  ..%d!"#$+e!"#f+gh+ !###!](((#(#3KLM2NOPQ833 3 3 34i jkklmnonpqrsrtunqvnwx yz,#!#'+](')+'%' (#,+*('('(''#!](('-) {#!](,,('+!(#")|(*%g(,##,#z #(`#),#*,#*,(#)-'-%_-,(''#!](! ('-!),(,#()#'*]*#+),' }?:C:G<DE>GI3~J=DFI<D=3€3BCJ:EJFCI=3KL2PQ83‚?ƒF„D=JDG>3CD;<>H:3@>;@>B>3 DB}DEJ:BCJ3D3}?DJ~ƒ3€„N0'e!3KL2N2L12LL2 2L2NONQ3J3€„NM0'e! KLL2NONQ%†#-#)##!"#]$

(346) ‡ˆ+]((#(I3€‰Š3 'z,#-'*‹]Œ%†#,*!!##,'-#, !(#")]#!](,,('{!%%./0N1234Z0N 234Z0NŽ3BDF„DBCJ3BD3 >@<IE>FHJ3(#"(!"#]$+('-!%%.g07+$gŒ+./0183 h#-,'*)(#!,'!"#]$+!##] (''*!(#")+#!](z*###-,(' #!](#z('!%d'3('-,#('-(#-'>?GJGJ>@J3 ;>?@DJB>~G:3K12L2ŽO2NOPQ833 †#-'(')#e*#z#,'a)' (#')#%g,#!##'#*#(#'"'3‘' (#,’3C>E;C:3CD;<>H:3EI:~J=JGDE>GI%b#e+3e,-e ! ( !!##)'  ' ('-,3 KP12 O2 12 Q83 #(#,'#,#(#)('!#,#-#'(]z-,^ *]3K1Q%b#e*]('!)#+](:@3B::@<ƒ3 #(#!!##)'('z(*#(@<:?3B:;<?ƒ@FIHGI83“>B>GJ>3”:G:<IFCG:3C>3 . 01.

(347) 34546759 45

(348) 69 64 6

(349) 

(350) 494

(351) 

(352) 

(353)     449

(354) 

(355) 766

(356) 

(357) 

(358) 69 49

(359) 6!"#$%& '()*+,-./01234,-5*+6/53(7-21-8+.+7- 

(360)   4 9 9  4 9546:;<4:;=46

(361) 64  44>6  46 ?@(-,6A-3BC/-B3(B3C34/"DEFGHI

(362) 6

(363)

(364)  6

(365) 

(366) 494

(367)  9 5*-5),/7JKLMJK$N#"O$P%B)@NQ"OP#%HR4  9 S 

(368)  45 4 DEFHT

(369) 4946 6 9 44  9546UHVWXYP#%& K-*66

(370) 9 

(371)  944S

(372) 6496Z945

(373) U   3449Z 444

(374) [  Z9 64 4ZH\9 9

(375) 454U  6

(376) 6  49 4 9 9

(377) 6U

(378)   9 5

(379) 

(380) 7S

(381)  9  695 6 UZ 4977[6

(382)  497 59H]7 

(383) 49U459

(384) S U F^ 

(385) U 6 67694Z 5(-7-.3,2/_`"OO"P#"PL"$P%& a49 6  4

(386) 9 5 6

(387) 95 766  Z9 

(388) 69 2__),-B-4268,+6A.53(7-21-82/&    . . 01.

(389) 3 56789

(390)      !"!#$%&!' () *+%,&%-./01/23454678404.-504/95/1/5:;4542<=:>?/@A04 BCD&*D B* D   E &C&*=0FG/AHIJ54K4L!')M!'NO4KPQRSO4KPQTUO4PVWXQ7O4 !')(#Y54678404.-504/95/1/5:;4Z4A[/-HA[4?<4\<-./01/23]  ^ F<-.:-J54<.IH5<A;04=0FG/AHIJ54K4L!'$_M`abc'#M!'E(d404A2e\I:A2.04 ./\IHFZ=Z;eA:;4LPVfNd454678404.-504/95/1/5:;4Z4A[/-HA[4?<4\<-./01/23     . . 01.

(391) 34 6789 7

(392)  98    34 !" #$%$&'()*+,-).,*/*+012314526781536967:48;<131=6>67=746?6@A7:41BC23D7 E*F*/G)&H-+.,-I-J-,(K$&H-+%,+,&'&(J,*GL'%L+#+#MNO7NPQORMS78<91581>C<17=7RM7 K-%KT,($&+:41BC23U=7V606=@8;@A7WX>X53C453=67Y6D2X7X7Z821[>X@3=67\;]58C<1^7 _C24D36@B`7@A14;@A7>6756421X018`7X7<4D:L+K-%J,-a%&'+.,-/*F)-%-+/+ba$%$G&+ c>CD?1>1[1<XX7d06e52XC<17f>X=C45;3&JT+g&FLG)%&H-h+i.,*G-/*%$&+a*E-,*J-,L'%&+ ?63C4X69D70X6<>153;@8>C<1+$+E*F*%$&+GLJ-I&J,LG)%&+/LK-%*%-+/+b*J&F,)&+$+ j629608XC7kX8B1:631[1<XX7d06e52XC<17f>X=C45;3C3D7WC0;@8>C<178678<10l7.*%*+.,-mh+ F,+n*Eh+oh+p$JK-/(K$&H-h jV606>17qr715UV7@A14;@A7>6756421X018`7:9D@^7d4D:`721>341[>l7sOR7151V;t7 536>1=X9;7151V;70X6<>181=6>C787:1=10D7:48C=[C29C<172658[DS7D723U4;@A7>67 :10536=XC7:48C:41=6081>;@A7V606e7=;2[D@81>17@A141V;7:9D@S7B6217:48;@8;>`7 8<96586>;@A701[C<[X=1u@X^7v+/()L(JK$Gn+/LK-%*%-+.-F(J*/-/&+E*F*%$*+ a*E-,*J-,L'%&+$+,*F$-a-H$G)%&h+Z8@8C<U91=l7@A64623C4;53;2`7V606>;@A7<4D:7 86=XC46Bl736VC[67w+-,*)+/LK,&(Lx+yz{h++ v)L(K*%&+/L%$K$+*%*a$)-/*%-+=710>XC5XC>XD70171VB6=U=72[X>X@8>;@AS7V606e7 ,*F$-a-H$G)%LGn+:9D@|+V606e7@8;>>1u@X1=;@A7:9D@S753151=6>C<17[C@8C>X6S7@865D7 34=6>X67@A141V;^77\;4U]>X1>17<4D:`7@A14;@A78756421X0186734=6Bl@l7017O7[637X7 :1=;]CB7O7[63+}{~|€S7=;104`V>X1>17:10<4D:`787@A141Vl7D348;?DBl@l75X`7:1=;]CB7‚7 a*J+}ƒ|„wh+ *+.,1<4C5B`7=7V606>X6@A7@8;>>1u@X1=;@AS7:101V>XC7B627jXC<C>A6<C>7X7 /(.h+}y†~+T)%*/*%-+.-H-,()&%$&+-+y†‡+/+E*F*%$T+ˆ‰Š+aTE+‹‰ŠiŒ+)I%$&'()&%$&+-+ y„‡+Š+aTE+Žyh+c41<4C5B`7460X1[1<X@8>l71@C>X6>17>67:10536=XC71VC@>1u@X7 %-/LGn+)I$*%+aTE+%*($a&%$*+F-JLGnG)*(-/LGnh+          + 01 .

(393) 23456389 3

(394) 3 5

(395)  3433 

(396) 9.  $%   

(397)  43 5    !  !

(398) 5& 4335 439 "6# "6# "6# *+ ,-++ .-/ (-0 3

(399) ''3 () *+88 "8*1(2# ".-,1)-(#".-,+1,-,# "0-01,,-+# +/ .-0+ .-,8 (-8* '

(400) '63 80 ),( "8,1)(# ".-.81,-.# "..--,.()#1 "0-21/-(#. 3 456789:;<4=7>?@A865< 9B?4>9A86CD4E6F94G?@<6B6H4I>6F7?AJ   

(401) 5,K4L@A?8?F49AMN4=6OP;D;Q48D89R454N6@6BD;Q4S7T=6;QK  . $%

(402) 5& "6# ,-8) ".-+18-/# ,-)+ ",-,10-2#.  . .   

(403) 589U333

(404) ''179>FC6@4=79;?B895D4IB1643 '

(405)  #9 .  . 00.

(406) 345678

(407) 

(408) 

(409) 

(410) 

(411) 

(412) 

(413) 

(414) !"#$

(415) %

(416) %

(417) &'

(418) ()*+

(419) '

(420) #'

(421) ,

(422) 

(423) %- . 345678 .

(424) +

(425) %

(426) %-

(427) 

(428) /#

(429) ,$

(430) %601237 34 %

(431) &

(432) ()*+

(433) '

(434) '

(435) 

(436) 

(437) 

(438) 5% 6 %-7 . . 01.

(439)  456789 

(440) 97976 588565 !"#$%&'()*+. .     456789,+"-!"#$%&'()"$.)$."& "/0!1"2%$&)$."("#%/3$0"" 466756987   . 5 .  01.

(441) 345 789

(442)

(443)   

(444) 

(445)    !"!#$#%&'(#)$'!*+,-'"* +.&/!01&'($  '1,&23-4!$ +-%&&5'&678!*'"90:'!4#3&+!;-%$:< =>?@ABC.D<"2'/!E '$%"#441F#3&/!G58H:5IJKLILMMNOP.   34Q RSTUVW9XY9Z

(446) 

(447) ZY [

(448) 9XY\[]99^Z_VW[\`Y9[

(449) abcde fghi.A@j>jhk.l>i>j>.lg@jBC@mlhg@@n@Aho@.-39 4*1"'(#p BB@.ngh.kjk?k.q.o@ijr5'24s%&# '$#*/6'-!>j>.nghkhi>Btu. &(!7! 9..i>hn>k?.vwko.i@?jhx..@ihj.vyzko.i@?jhx.AhB@ghk.A.ij?. -!-%&&9+3#*%! 3{!|'%!"2!-'0..g>j@.A.ij?.l>i>j>P.}ht3!$! (12' -! '' ,4#6+.)3' 0/%(.' "090&#2-!$ !~M6'!2'0$ >hg@@€1, "40- '!&'3&16 '2%4 ''!"2%&6'17#$ !%!&4$!g?..y. 6'!2'#G'-%&2%3& !*2"#*69$2'66'!2'#$#!"&+39‚,L*/I2/Or ƒn@g>iBjh.A.g>Bh.>lho?.BC@g.Ak>o>€.>@@A>j>.n@BC@ijht. lhj@i>hnj.@.lk..€jk.&'( '11"-!299+3#*G*'&!6*!7#6'xP „n>g>.lg@jBC@mlhg@@n?.vfhj> .†f‡ˆ‰zznx.Ang@A>i>j@.i@.@gh€.A. -!&#39'"'&+39-39 4u.-%&&9*01"4+rŠ4%23' '*! '4!%!$ ! "41%3902%$''2390"%3&-!*!3+n?€@khg?u.n@i>A>j@.€hjP.‹>ljh. &'/!$#$#-!"7! ##($&"4$„Œƒ.v>joP.>i>jBhi.€mh.?n@gxu.. h€hg@>gi@og>mP.Ž!!9%& '1%s/!3{!$#3{$#2! #$ !-(12 ' @gh€@A@ˆ-03{%&#2!$G:Or8!<3s$20%! 3{!|'%!"2!-1.€j@A>j@.n@. g@jh.ng>$9$9 #*&19)p!gh€.n@i"/* 4%#3{-(4)%!2!$/!rŠ ghBC.n@gBt>BC.n@i>A>j@.‰yzk€.@€.mt@€@oBjht.vzu‘.=>’€xu.@in@Ahij@.n@. LM*6,“M*6'“M*6rŽ!27#*-! '1!"#" !-(#rŽ'%$"&-!%39,&$'%9+B>. $#&'6'0&17#3{!"2%&6',"4 !$'(*4%'(!.<*'2%!'!6!/'3jBC.vm€@g>. A@>u.'"$!'"4,/%&##O,2!69!<3#4!6!/'3&#3{'3#4!*4%#3&#3{r” "4#"|239! 19+3#1&$ !!&#"2-!-(13&#!"2%&6!$!ˆ-03{%&#2!$#3{ -!$#79“M'6!)3'-! /!-(#1,&!*'"&2'2%$'•yw–P.. —(!)p '%! 3{!|'%!"2!-!$/!&$#2!  '*:4%$( 2'62 )3'*'14r=>BCk>.n@.n@lg>j?.˜„Œ.n@ii>A>j@.ngo@@A>j?.i@. l>i>j>.B@khgBjho@P.™3 ' !!/s6+612!3#4!&0'"2(2!*s%2!$#:, A€?B>j@.jmhBthP. . . . 01 .

(450) 343 6789

(451) 

(452) 7 ! "#$%&%'()*$+*,#-.,/*+)&.0$12345$+*,#-.,/16789:7;3<5<:=5$>?@A+%&$B.+,#&$ "(C(&D#&E$FA?G$"#$H/)*I#,#J%&(%$K%L%&*+M$)%J(.D(&$J*C#/)*D,%&#$<N8O<PQ$ R77:ST58U6V:S4NU1=:6WXYZ[\6]45^5<_S568594<O86`N91abc36dZeXf=6ghi@jE$kElI$ mn@op$J$lkk-'$J#L*$L.D,*'#J%&.0q$($rBA$sliEtiI$u%tnroivtntoE$tEwxI$ u%ntroivntoE$ywExI$u%@'E$tI$u%upe61917:;SN5S:6T56Y`6<5Tb6T:^43`5<_Sbz\6{56 578_c5<_SN_6<3SNPO<61234565785=8_|5<_SN_6V:``}1:^46~{e6]€6N6NS‚{ƒ6<\„\ 6 s†G$‡/#,,./E$‡M.$A+/(HHD$ˆ.D.%/+M$‰&D,(,Š,.G$FA?qG$ ‹T6P_2L.0$#D#K*$K%L%&.0$H5Œ8_S56756YZ|`6P8<N67:;S:a6S_6<:/D.&(%&$ T<1754_^5<36 dR{€6 Ž„z6 Œ:9758:TSN56 789:T6 <3P5S_SN:|6 Œ_T_SN_6 Œ85Sc5UNŒ:85^P575<:=5\6‘=5TSN:69678545P5;:|6T56P_2T:a6785ŒO<PN6c345|:483c9S:6 T5T_S56756YZZ’`6P8<Ne6_6S_^4Q7SN:6756lk’`6#LH#J(.L&(+M$H/).cN<cN_;6 -#&#C'#&%'&*+ME$^PN:85<_S3c6789:cN<65P8:`5S3|$%&,*I.&#-$H#J(./)+M&(#J*-$ `N|U5c34O<\6“5648<_ab+.0$pk$-(&Š,$(&CŠK%+0(e6Œ:96T5^4Q716<N_4;_e675TT_S56P5|O8PN6 N7545SNc9S:a6`N9N:6:83485c34O<6dNSP1Œ_ca_6YW6|NS146756T5T_SN16756„6|`68594<5816 `N91abc:=5z\$“565T<N85<_SN16d„6ZZZ65Œ854O<6”6|NS14Q6789:96W6|NS14z$N61^1SNQcN16 ^17:8S_4_S41e6T56P5|O8:P$T5T_S56756„6|`6“~]6N6<N85<_S56d„6ZZZ65Œ854O<6”6|NS14Q6 789:96W6|NS14ze6_Œ361^1Sb•6S_T|N_86SN:9<Nb9_S3c6789:cN<cN_;\66%C$H/)*I#,#J%&.$ P5|O8PN69_<N:^9_&#$J$&(.J(.'C(:a65ŒaQ45cN6“~]$s#CG$„ZZ’`ze6193^P1abc6|_4:8N_;6T56 %&%'()*$+*,#-.,/*+)&.0G$o+.&(%&#$lk$kkk$`N|U5c34O<\$ “57;1c93S36 5^P89:`5<5–7Qc:893P5<:6 Œ:9758:TSN56 756 75Œ8_SN16 789:^bc95S56789:96UN`486P5|O8P5<36—Z’|e6Œ361^1Sb•69_SN:c93^9c9:SN_6`19:|\$$ F)*DC%&*$-%,./(%;6TN_=S5^43c9S367893=545<3<_S569=5TSN:69657N^_Sb675<32:a6 785c:T18b69675|NSNQcN:|6:4_716`N936:83485c34O<\$ “N:8<^9:6T<N:6Œ_T_S:6785ŒO<PN6^4_S5<N;36P5S485`Q6N954375<b6Œ:96^<5N^45cN6 _S43=:S5<:a\6~3;36456789:cN<cN_;%$4:=56^_|:=56N9543716c56789:cN<cN_;_6 -#&#C'#&%'&.$1234:6T56Œ_T_SN_e65LH#J(.L&(#$‰I˜$'ŠK$‰I™$,.0$D%-.0$H#LC'%D*G$$ 6Œ_T_SN16<3P5893^4_S56S_^4Q71abc:6789:cN<cN_;_š$ ›$ ˜Š',(˜(v$‡/(H'.–@#'#Š/$@#&,/#'$ˆ.%I.&,$s˜#ŠD.$‰I™lœ>‰‡@E$˜#ŠD.$ ‰I™t%œˆrE$˜#ŠD.$‰I™lœˆr–@*žq$"%C#@*,#-%,(#&E$$ ›$ ‰I™l–r@ž$‰D#,*H(+$@#&,/#'$B.+C-%&@#Š',./E$$ ›$ ˜#ŠD.$?&,(–nŠ-%&$@"p–r@žE$C'#&$F@n‡lE$B.+C-%&@#Š',./$ ›$ ˜#ŠD.$?&,(–nŠ-%&$@"i$ˆr–@*žE$C'#&$˜‡plkE$"%C#@*,#-%,(#&$ ›$ ˜#ŠD.$?&,(–nŠ-%&$@"y$ˆr–@*žE$C'#&$"mtžE$"%C#@*,#-%,(#&$ ›$ ˜#ŠD.$?&,(–h1|_S6V[Ÿ 6¡ƒVe6P`5S6YZ~ \Y€–plE$B"$rM%/-(&I.&$ ›$ ˜#ŠD.$?&,(–nŠ|_S6V[¢£6¡ƒVe6P`5S6~Ye6~{6“_8|NS=:S$ 01 .

(453) 3 3 3 3 3 3 3 3 3. 56789

(454) 7  6 !" #9  56789

(455) 7 $6 %&!" #9  56789

(456) 7 '()6 (*+,-8

(457) 98 56789

(458) 7 6  !" #9  56789

(459) - .*)6 .*/.!" #9  56789

(460) 7 .)6 01!" #9  56789

(461) 7 (26 0!" #9  56789

(462) 7 & 6 &.1!" #9  56789

(463) 7 .)6 5 .!" #9  3456789:;<=>:<?@9>:A:=B8>69CDCEF9G967BHI:7J9CKLMN  O6P-

(464) P! Q1RST"6U4 P 7 874V6V7PW9R *RJ9FX9AY8>HAY9769<6>;8G58Z@9G9J.1 8<[\]9<B678^G_AHAY9I>J=@9;87B>8`7_a9E[^7G:b9=8Z8<B6c:9

(465) -#9 -]95`69;B[>HAY9 6U PU9  JbHB8 ^Hb:?9 ^HdG:7G87HAY ;8d=`:d:7B6>7HAY9 =>Z:AG^AG6c9 6 66  -P!\HcH98A:7G67:9^9I>J=G:9;87B>8`7:?a9%T-4" -P!P!6"-P!  <6>;8G58Z@efg98<[\h6U PU6 6ijkl $71 P!6"-P!

(466) -#9 -m(2& ..*./  nopq rstuvwtqxytyzxyz{wstq |76`GZ@ <B6BH<BHAZ7_9 =>Z:=>8^65Z8789 Z9 ^H;8>ZH<B67G:d9 =>8I>6d7 , , 2/Q P9 PW}%59~S/V 9"T8U-9

(467) V 9V"6P9~7"-  U- 8

(468) 

(469) -8

(470) -PU 9W6P9  6\6567:9ZdG:77:9=859;_B:d9BH=J9>8Z;c65J9567HAYJbH^6?_A9 B:<BJ9€8c8d8I8"6T, " 6T/9A:`J9=8>[^767G69^6>B8‚AG9A:AY9G`8‚AG8^HAY9^9 5^[AY9676`GZ8^67HAY9=8=J`6A?6AY9Z6<B8<8^6789B:<B9ƒ5 !

(471) 9-/ =>ZH=65;J9=8>[^76„9^6>B8‚AG9ZdG:77HAY9^9^G@A:?97Gb95^[AY9=8=J`6A?6AY9 U8

(472) 686T 6

(473) 98

(474)   U-T"  PW  0$ †"78 8/38

(475) 686T 9

(476) -P! B:<B[^9\Hc89J^6>J 6T 9>8Z;c65:d97G:=6>6d:

(477) "-PU -  U6T -P! U 9 -P!?6;9>[^7G:b98A:7G67_9<B8<J7;8^89d6c_9=8=J`6A?_a‡`8‚AG8^:9567:9 V"9

(478) "-PU 9  U6T 6UT-6"U-8

Cytaty

Powiązane dokumenty

Na podstawie dwóch badań klinicznych (łącznie zbadano 400 chorych, dawki leku 10–20 mg/d.) memantyna została zarejestro- wana przez Food and Drug Administration od 2003 roku

Celem pracy była ocena odsetka i bezwzględnej liczby aktywowanych limfocytów B i T krwi obwodowej i  szpiku kostnego chorych na CLL oraz ocena korelacji między limfocytami

Przewlekle utrzymujący się uogólniony stan zapalny w przebiegu łuszczycy, stosowanie leków ogólnych w terapii tego schorzenia, a także często występujący niezdrowy styl życia

Również chorych na cukrzycę typu 2 dotychczas skutecznie leczonych dietą, cechujących się poposiłkowymi stężeniami glukozy w osoczu krwi poniżej 180 mg/dl (10,0 mmol/l)

Oleate hydratases (Ohys, EC 4.2.1.53) are a class of enzymes capable of selective water addition reactions to a broad range of unsaturated fatty acids leading to the

 skrobia kukurydziana poddana reakcji utlenienia wykazuje większą ilośd grup aldehydowych niż skrobie dialdehydowe, otrzymane ze skrobi ziemniaczanej,.  po

Celem podjętych badań była ocena częstości występowania poszczególnych genotypów polimorfizmu rs11118133, ilościowa ocena i porównanie ekspresji CR1 na komórkach krwi

Większość z nich wykazała się negatywnym nastawieniem i stwierdzi- ła, że denerwują ich emitowane w mediach spoty reklamowe (35%). Dlatego badani, gdy tylko jest to