Na podstawie poczynionych obserwacji można wywnioskować, że zaproponowane w rozprawie podejście badawcze umożliwia wszechstronną analizę mechanizmów rządzących zaangażowaniem Cx43 w mikroewolucję raka prostaty i GBM. W szczególności można z nich wyciągnąć następujące wnioski:
1. Istnieją bezpośrednie związki między ekspresją białek Snail-1 oraz Cx43 w nowotworach tak od siebie odległych pod względem pochodzenia i przebiegu jak rak prostaty i GBM.
2. Opisana w pracy rola Snail-1 w mikroewolucji inwazyjnych sub-populacji komórek GBM umożliwia stosowanie go jako markera złośliwości glejaków.
3. Stwierdzone podobieństwa między mikroewolucją komórek raka prostaty i GBM i między rolą Cx43 w procesie mikroewolucji inwazyjnych sub-populacji komórek obu typów nowotworów wskazują na istnienie podobnych mechanizmów rządzących procesem nowotworzenia w różnych tkankach.
4. Nowe fakty na temat roli Snail-1 oraz Cx43 w regulacji potencjału inwazyjnego komórek raka prostaty i glejaków pozwalają na uzyskanie pełniejszego obrazu rozwoju obu typów nowotworów. Glejaki nie wywodzą się z komórek nabłonkowych, więc w ich przypadku nie można mówić o procesie przejścia epitelialno-mezenchymalnego. Jednak ekspresja białka Snail-1 oraz związane z nią zmiany fenotypowe świadczą
126 o zaangażowaniu w progresję glejaków procesu podobnego do EMT. Proces ten nie był do tej pory przedmiotem pogłębionych analiz.
127
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