Wpływ rodzaju podłoża na uwalnianie diklofenaku sodu z półstałych postaci leku

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Impact of base type on diclofenac sodium release

from semi-solid dosage forms

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Anna Banyś, Beata Sarecka-Hujar, Andrzej Jankowski, Monika Zalewska

ABSTRACT

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Zakład Technologii Postaci Leku Katedry Farmacji Stosowanej Wydziału Farmaceutycznego z Oddziałem Medycyny Laboratoryjnej Śląskiego Uniwersytetu Medycznego w Katowicach

A D D R E S S F OR C O R R E S P ON DE N C E : Dr n. farm. Anna Banyś

Katedra Farmacji Stosowanej, Zakład Technologii Postaci Leku Wydział Farmaceutyczny

z Oddziałem Medycyny Laboratoryjnej Śląskiego Uniwersytetu Medycznego w Katowicach

ul. Kasztanowa 3 41-200 Sosnowiec tel.: +48 32 269 98 20 e-mail: abanys@sum.edu.pl

eISSN 1734-025X www.annales.sum.edu.pl

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INTRODUCTION

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Aim of the study

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Fig. 1. Diclofenac sodium release kinetics at 37°C.

Ryc. 1. Kinetyka uwalniania diklofenaku sodu w temperaturze 37°C.

Fig. 2. Comparison of diclofenac sodium amounts released from all analyzed preparations at 32°C and 37°C within 3 hours.

Ryc. 2. Porównanie ilości uwolnionego diklofenaku sodu z wszystkich analizowanych preparatów w temperaturze 32°C i 37°C w czasie 3 godzin.

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Table I. Velocity release constant values k and release half-time t1/2 according to primary kinetics

Tabela I. Wartości stałych szybkości uwalniania k oraz czasu połowicz-nego uwalniania t1/2, dla badanych preparatów według kinetyki I rzędu

Preparations k [h-1] t1/2 [h] 32°C 37°C 32°C 37°C Veral 2.37 x 10-2 _{3.99 x 10}-2 _{29.24 17.39} Diclac Lipogel 1.90 x 10-2 _{1.94 x 10}-2 _36.57 _35.74 Gel-type prepara-tion (glycerol ointment) 4.90 x 10 -2 _{7.00 x 10}-2 _{14.14 9.91} Lipophilic prepara-tion (Vaseline) – 7.29 x 10-4 – 951.09 Absorption prepara-tion (Eucerine) – 4.68 x 10-4 – 1481.86 Emulsion prepara-tion (Lekobaza) 2.36 x 10-3 2.53 x 10-3 293.22 273.47 Emulsion prepara-tion (Hascobaza) 2.55 x 10-3 2.69 x 10-3 272.06 258.10

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