Supplementary Table 26
Overall oral and pharynx cancer associations ( 6p21.32 )condition on DRB1*1301-DQA1*0103-DQB1*0603 haplotype Unconditional rs rs3828805 6:32636120 HLA-DQB1 C T 0.75 0.72 1.30 rs28418426 6:32619654 HLA-DQA1 C T 0.57 0.53 1.29 rs17612852 6:32620572 HLA-DQA1 A G 0.78 0.74 1.30 rs9273440 6:32627561 HLA-DQB1 C T 0.80 0.77 1.30 rs1049213 6:32627773 HLA-DQB1 G A 0.80 0.77 1.29 rs2157051 6:32658624 A G 0.83 0.80 1.30 rs3135002 6:32668439 C A 0.84 0.81 1.31 rs3135001 6:32670136 C T 0.82 0.79 1.29 rs3135190 6:32667946 G T 0.82 0.79 1.29 rs3129782 6:32648719 A G 0.80 0.77 1.28 rs3134995 6:32672089 A G 0.18 0.21 0.78 rs3135006 6:32667119 A G 0.19 0.22 0.78 rs9274614 6:32635846 HLA-DQB1 G C 0.81 0.78 1.28 rs3134975 6:32652581 C T 0.81 0.78 1.28 6:32630916 6:32630916 T G 0.79 0.77 1.28 rs3129720 6:32663631 C T 0.81 0.78 1.28 rs3129719 6:32661779 G T 0.81 0.78 1.28 rs3134994 6:32637680 C T 0.81 0.78 1.28 rs3830058 6:32634010 HLA-DQB1 A G 0.81 0.78 1.28 rs3134976 6:32652305 C A 0.81 0.78 1.28 rs1049225 6:32627747 HLA-DQB1 A G 0.19 0.22 0.78 rs1049055 6:32634387 HLA-DQB1 G A 0.19 0.22 0.78 rs9274626 6:32636040 HLA-DQB1 C T 0.80 0.77 1.28 rs71789649 6:32634403 HLA-DQB1 I D 0.19 0.22 0.78 6:32625209 6:32625209 T C 0.51 0.47 1.25 rs1049062 6:32634302 HLA-DQB1 G A 0.81 0.78 1.28 rs3129780 6:32647701 A T 0.69 0.65 1.25 rs3104376 6:32600003 A G 0.18 0.21 0.79 rs9273394 6:32627082 HLA-DQB1 A G 0.24 0.28 0.80 rs3104369 6:32602482 A G 0.22 0.26 0.80 rs28986221 6:32635312 HLA-DQB1 A G 0.18 0.21 0.79 rs9273500 6:32628342 HLA-DQB1 A G 0.15 0.17 0.78 rs9274483 6:32633809 HLA-DQB1 C T 0.76 0.73 1.26 rs17612489 6:32614749 HLA-DQA1 A T 0.52 0.49 1.23 rs3129726 6:32678206 A G 0.81 0.78 1.26 rs9271300 6:32581582 C G 0.42 0.45 0.83 rs9274666 6:32636543 A G 0.37 0.40 0.83 rs548102104 6:32598813 A G 0.03 0.05 0.57 rs3135461 6:32680122 A G 0.81 0.78 1.26 rs9273426 6:32627434 HLA-DQB1 C A 0.53 0.50 1.22 rs9271378 6:32587300 G A 0.51 0.48 1.19 rs17612562 6:32615446 HLA-DQA1 G T 0.43 0.40 1.23 Chr:posa Effect
rs9271082 6:32576086 C T 0.83 0.80 1.27 rs4947344 6:32677846 A G 0.26 0.29 0.82 rs113016235 6:32584977 G T 0.11 0.15 0.77 rs9273432 6:32627485 HLA-DQB1 C T 0.43 0.40 1.24 rs17612900 6:32620838 HLA-DQA1 C G 0.41 0.38 1.24 rs73730372 6:32584581 A G 0.11 0.15 0.77 rs35879651 6:32595857 T C 0.05 0.07 0.68 rs200911565 6:32596799 D I 0.09 0.12 0.75 rs146486595 6:32479729 T A 0.03 0.05 0.63 rs34967069 6:32591248 T C 0.06 0.08 0.70 6:32625026 6:32625026 A G 0.35 0.32 1.24 rs34481484 6:32605861 HLA-DQA1 G A 0.05 0.07 0.70 rs74379225 6:32606742 HLA-DQA1 G A 0.05 0.07 0.70 rs62404085 6:32604384 HLA-DQA1 A G 0.05 0.07 0.70 rs73730377 6:32584880 G A 0.11 0.14 0.77 rs78712211 6:32610300 HLA-DQA1 T C 0.06 0.08 0.71 rs34831921 6:32590768 A C 0.09 0.12 0.76 rs73728618 6:32591567 A T 0.09 0.12 0.76 rs35867827 6:32592068 C T 0.09 0.12 0.76 rs115826298 6:32596985 A G 0.05 0.07 0.70 rs9273105 6:32612601 HLA-DQA1 A G 0.54 0.51 1.21 rs116489113 6:32596496 G A 0.05 0.07 0.70 rs36232342 6:32587618 C T 0.05 0.07 0.70 rs115527034 6:32598356 C T 0.05 0.07 0.70 rs151002495 6:32598680 A G 0.05 0.07 0.70 rs111294540 6:32587359 A C 0.05 0.07 0.70 rs34116693 6:32587603 T C 0.05 0.07 0.70 rs113177970 6:32584749 T C 0.05 0.07 0.70 rs62406298 6:32582541 G A 0.05 0.07 0.70 rs62406306 6:32585520 A T 0.05 0.07 0.70 rs113468765 6:32583749 T G 0.05 0.07 0.70 rs113676242 6:32583719 G C 0.05 0.07 0.70 rs34645399 6:32589169 G A 0.05 0.07 0.70 rs34692256 6:32585805 G A 0.05 0.07 0.70 rs62406299 6:32582558 C G 0.05 0.07 0.70 rs62406301 6:32582807 C A 0.05 0.07 0.70 rs62406302 6:32584662 G T 0.05 0.07 0.70 rs76815088 6:32588713 C T 0.05 0.07 0.70 rs35390996 6:32587663 A G 0.05 0.07 0.70 rs112953812 6:32591500 A G 0.05 0.07 0.70 rs115076650 6:32588215 G A 0.05 0.07 0.70 rs80257164 6:32587967 A C 0.05 0.07 0.70 rs114076271 6:32591717 A G 0.05 0.07 0.70 rs35786457 6:32590165 A G 0.05 0.07 0.70 rs112447098 6:32589544 A C 0.05 0.07 0.70 rs34135912 6:32589793 A G 0.05 0.07 0.70 rs35025478 6:32590162 G A 0.05 0.07 0.70 rs35947801 6:32590187 A T 0.05 0.07 0.70
rs34412149 6:32591892 G A 0.05 0.07 0.70 rs78390183 6:32593040 T C 0.05 0.07 0.70 rs34720986 6:32593270 C G 0.09 0.12 0.76 rs78496075 6:32608967 HLA-DQA1 G A 0.06 0.08 0.71 rs9274574 6:32635219 HLA-DQB1 A G 0.44 0.41 1.19 rs115632345 6:32588480 T A 0.05 0.07 0.70 rs116831885 6:32595141 T C 0.05 0.07 0.70 rs36222081 6:32634373 HLA-DQB1 A G 0.44 0.41 1.19 rs62406889 6:32672214 T G 0.05 0.07 0.71 rs139474416 6:32620610 HLA-DQA1 D I 0.06 0.08 0.72 rs28383263 6:32585843 G C 0.05 0.07 0.70 rs9274440 6:32633196 HLA-DQB1 G A 0.45 0.42 1.19 rs62406300 6:32582772 A G 0.05 0.07 0.70 rs566952760 6:32592793 T C 0.05 0.07 0.69 rs9273060 6:32612114 HLA-DQA1 G A 0.55 0.51 1.21 rs9273415 6:32627310 HLA-DQB1 T C 0.56 0.52 1.20 rs35975014 6:32610075 HLA-DQA1 G A 0.06 0.08 0.72 rs2854272 6:32629680 HLA-DQB1 G A 0.44 0.41 1.18 rs146668528 6:32598028 T C 0.04 0.06 0.68 rs9274622 6:32635990 HLA-DQB1 C T 0.44 0.41 1.18 rs9274500 6:32634024 HLA-DQB1 T A 0.44 0.41 1.18 rs34430979 6:32608425 HLA-DQA1 A C 0.05 0.07 0.71 rs201607901 6:32589234 D I 0.05 0.07 0.71 rs9274653 6:32636254 HLA-DQB1 G A 0.44 0.41 1.18 6:32634040 6:32634040 I D 0.44 0.41 1.18 rs17843577 6:32615510 HLA-DQA1 T C 0.60 0.57 1.20 rs144081603 6:32589374 C T 0.05 0.06 0.70 rs9273335 6:32623348 G A 0.61 0.57 1.20 rs1140317 6:32632605 HLA-DQB1 A C 0.46 0.43 1.20 rs12918 6:32627386 HLA-DQB1 T C 0.40 0.38 1.20 rs17843579 6:32615527 HLA-DQA1 G T 0.61 0.58 1.19 rs9272293 6:32603742 HLA-DQA1 G A 0.62 0.58 1.19 rs9272602 6:32607666 HLA-DQA1 A G 0.54 0.51 1.21
a SNP position according to NCBI genome build 37 (Hg19) b Fixed-effects meta-analysis OR and p-values
Overall oral and pharynx cancer associations ( 6p21.32 )condition on DRB1*1301-DQA1*0103-DQB1*0603 haplotype Unconditional Conditional P 9.62E-14 1.24 1.07E-07 2.19E-13 1.23 1.84E-08 2.87E-13 1.23 1.79E-07 1.93E-12 1.22 2.40E-06 7.05E-12 1.21 5.00E-06 9.41E-12 1.22 2.27E-05 1.03E-11 1.22 2.86E-05 1.12E-11 1.21 1.03E-05 1.30E-11 1.20 1.18E-05 1.50E-11 1.20 1.06E-05 1.76E-11 0.83 1.29E-05 2.09E-11 0.83 1.46E-05 2.11E-11 1.20 1.47E-05 2.20E-11 1.20 1.50E-05 2.43E-11 1.20 1.64E-05 2.49E-11 1.20 1.66E-05 2.49E-11 1.20 1.66E-05 2.54E-11 1.20 1.70E-05 2.85E-11 1.20 1.99E-05 2.91E-11 1.20 1.89E-05 2.94E-11 0.84 2.02E-05 3.06E-11 0.83 1.95E-05 3.26E-11 1.20 1.88E-05 3.95E-11 0.84 2.19E-05 4.14E-11 1.20 1.18E-07 5.78E-11 1.19 3.31E-05 1.02E-10 1.18 6.64E-06 1.22E-10 0.84 4.13E-05 1.35E-10 0.85 8.80E-06 2.05E-10 0.85 4.74E-05 2.25E-10 0.85 2.05E-04 2.35E-10 0.84 4.06E-04 2.82E-10 1.18 5.60E-05 2.99E-10 1.18 7.75E-07 4.45E-10 1.17 1.52E-04 5.49E-10 0.87 5.15E-06 5.68E-10 0.87 1.16E-05 6.04E-10 0.67 9.53E-02 7.10E-10 1.17 2.18E-04 1.08E-09 1.18 2.18E-06 1.35E-09 1.15 4.09E-06 1.54E-09 1.18 1.08E-06 ORc Pc
1.60E-09 1.19 4.09E-05 1.70E-09 0.87 8.15E-05 2.72E-09 0.86 5.88E-03 2.92E-09 1.19 1.84E-06 3.50E-09 1.19 2.86E-06 3.65E-09 0.86 6.66E-03 3.71E-09 0.98 9.48E-01 4.06E-09 0.86 2.51E-02 4.51E-09 0.78 3.45E-02 4.80E-09 0.87 3.20E-01 5.19E-09 1.19 2.33E-06 5.57E-09 1.12 6.96E-01 5.81E-09 1.14 6.65E-01 5.83E-09 1.14 6.63E-01 5.87E-09 0.86 6.58E-03 6.23E-09 0.91 5.38E-01 6.30E-09 0.86 3.67E-02 6.30E-09 0.86 3.68E-02 6.31E-09 0.86 3.68E-02 6.47E-09 1.17 5.97E-01 6.51E-09 1.16 1.10E-05 6.52E-09 1.17 5.95E-01 6.71E-09 1.18 5.74E-01 6.76E-09 1.19 5.70E-01 6.77E-09 1.19 5.70E-01 6.78E-09 1.19 5.72E-01 6.78E-09 1.19 5.71E-01 6.79E-09 1.19 5.71E-01 6.79E-09 1.19 5.71E-01 6.79E-09 1.19 5.71E-01 6.79E-09 1.19 5.71E-01 6.79E-09 1.19 5.71E-01 6.79E-09 1.19 5.71E-01 6.79E-09 1.19 5.71E-01 6.79E-09 1.19 5.71E-01 6.79E-09 1.19 5.71E-01 6.79E-09 1.19 5.71E-01 6.79E-09 1.19 5.71E-01 6.79E-09 1.19 5.71E-01 6.79E-09 1.19 5.71E-01 6.79E-09 1.19 5.71E-01 6.79E-09 1.19 5.71E-01 6.79E-09 1.19 5.71E-01 6.80E-09 1.19 5.70E-01 6.80E-09 1.19 5.70E-01 6.80E-09 1.19 5.70E-01 6.81E-09 1.19 5.70E-01 6.81E-09 1.19 5.70E-01
6.83E-09 1.19 5.67E-01 7.10E-09 1.19 5.55E-01 7.32E-09 0.86 3.67E-02 7.40E-09 0.92 5.43E-01 7.51E-09 1.15 4.00E-06 7.82E-09 1.20 5.29E-01 8.09E-09 1.23 4.83E-01 8.63E-09 1.15 3.90E-06 8.71E-09 0.99 9.62E-01 9.51E-09 0.91 5.29E-01 9.60E-09 1.28 4.07E-01 1.12E-08 1.15 7.96E-06 1.13E-08 1.19 5.69E-01 1.32E-08 1.16 5.49E-01 1.47E-08 1.16 2.19E-05 1.64E-08 1.16 2.25E-05 1.89E-08 0.91 5.26E-01 1.95E-08 1.14 9.10E-06 2.09E-08 1.15 5.50E-01 2.10E-08 1.14 9.50E-06 2.13E-08 1.14 9.65E-06 2.14E-08 1.14 6.58E-01 2.30E-08 1.26 4.34E-01 2.34E-08 1.14 1.04E-05 2.53E-08 1.14 1.09E-05 2.57E-08 1.15 4.10E-05 3.05E-08 1.26 3.32E-01 4.15E-08 1.15 5.88E-05 4.19E-08 1.15 2.76E-05 4.58E-08 1.16 1.75E-05 4.99E-08 1.14 7.23E-05 5.49E-08 1.14 6.10E-05 1.04E-07 1.15 9.35E-05
