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chronic diseases. It has been postulated that fundamental changes in the diet and other lifestyle conditions that occurred DIWHUWKH1HROLWKLF5HYROXWLRQDQGPRUHUHFHQWO\ZLWKWKHEHJLQQLQJRIWKH,QGXVWULDO5HYROXWLRQDUHWRRUHFHQWWDNLQJLQWR account the evolutionary time scale for the human genome to have completely adjust. In contemporary Western populations DWOHDVWRIGDLO\HQHUJ\LQWDNHLVSURYLGHGE\IRRGVWKDWZHUHUDUHO\RUQHYHUFRQVXPHGE\3DOHROLWKLFKXQWHUJDWKHUHUV including grains, dairy products as well as refined sugars and highly processed fats. Additionally, compared with Western GLHWV3DOHROLWKLFGLHWVEDVHGRQUHFHQWO\SXEOLVKHGHVWLPDWHVRIPDFURQXWULHQWDQGIDWW\DFLGLQWDNHVIURPDQ(DVW$IULFDQ Paleolithic diet, contained more proteins and long-chain polyunsaturated fatty acids, and less linoleic acid. Observational studies of hunter-gatherers and other non-western populations lend support to the notion that a Paleolithic type diet may UHGXFHWKHULVNRIFDUGLRYDVFXODUGLVHDVHPHWDEROLFV\QGURPHW\SHGLDEHWHVFDQFHUDFQHYXOJDULVDQGP\RSLD
Moreover, preliminary intervention studies using contemporary diet based on Paleolithic food groups (meat, fish, shell-ILVKIUHVKIUXLWVDQGYHJHWDEOHVURRWVWXEHUVHJJVDQGQXWV UHYHDOHGSURPLVLQJUHVXOWVLQFOXGLQJIDYRUDEOHFKDQJHVLQULVN IDFWRUVVXFKDVZHLJKWZDLVWFLUFXPIHUHQFH&UHDFWLYHSURWHLQJO\FDWHGKDHPRJORELQ +E$F EORRGSUHVVXUHJOXFRVH WROHUDQFHLQVXOLQVHFUHWLRQLQVXOLQVHQVLWLYLW\DQGOLSLGSURILOHV/RZFDOFLXPLQWDNHZKLFKLVRIWHQFRQVLGHUHGDVDSRWHQ-tial disadvantage of the Paleolithic diet model, should be weighed against the low content of phytates and the low content
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of sodium chloride, as well as the high amount of net base yielding vegetables and fruits. Increasing number of evidences VXSSRUWVWKHYLHZWKDWLQWDNHRIKLJKJO\FHPLFIRRGVDQGLQVXOLQRWURSLFGDLU\SURGXFWVLVLQYROYHGLQWKHSDWKRJHQHVLVDQG SURJUHVVLRQRIDFQHYXOJDULVLQ:HVWHUQFRXQWULHV,QWKLVFRQWH[WGLHWVWKDWPLPLFWKHQXWULWLRQDOFKDUDFWHULVWLFVRIGLHWV found in hunter-gatherers and other non-western populations may have therapeutic value in treating acne vulgaris. Addition-ally, more studies is needed to determine the impact of gliadin, specific lectins and saponins on intestinal permeability and the pathogenesis of autoimmune diseases.
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